FJQ3110 Microphysiological Systems 6.0 credits

Mikrofysiologiska system

Offering and execution

Course offering missing for current semester as well as for previous and coming semesters

Course information

Content and learning outcomes

Course contents *

The course is organized as lecture series, consisting of ~12 lectures combined with seminars where the student will present and discuss their project works. The lecture and seminar series will be shared between the universities as web conferences. The participants of the course will be divided in groups with at least two participants from each university. The groups will be given a topic for in depth studies of relevant scientific literature. This project work will be presented as a seminar and a written review. See also detailed syllabus below. 

Intended learning outcomes *

After completing the course, the student should be able to:

• Reflect over the need for and limitations of systems mimicking and predicting human physiology

• Understand the critical components of biomimetic systems 

• Understand the basic principles in microfluidics and be able to describe material options and fabrication processes

• Understand the differences in vitro models including Organ Chips, Organoid cultures, other 3D cell cultures and conventional cell cultures.

• Analyze the needs for analytical readouts of biomimetic systems and understand different sensing principles that are compliable with the technologies

• Understand the basic principles in extrapolations of in vitro data to human in vivo physiology 

• Analyse and reflect over the use of biomimetic systems in drug development and clinical settings  

• Analyze and discuss the scientific literature in biomimetic systems

• Analyze and reflect over the sustainability aspects of Biomimetic systems, in particular the aspects of environmental and societal impact of both the current status of the studies and future dissemination of the technology

Course Disposition

The course is organized as lecture series, consisting of 12 number of lectures combined with seminars where the student will present and discuss their project works. The lecture and seminar series will be shared between the universities as web conferences. The participants of the course will be divided in groups with at least two participants from each university. The groups will be given a topic for in depth studies of relevant scientific literature. This project work will be presented as a seminar and a review.

 

Preliminary detailed syllabus: 

Week 1: The needs for and challenges of mimicking the human physiology:

Why we should build systems that mimic the human physiology? introduction to physiology, How the human physiology is different from other animals

Week 2:  Introduction to in vitro systems:

Overview of in vitro system, what are their benefits and limitations 

Week 3: Microfluidic systems:

Introduction to microfluidics, flow, fabrication, materials  

Week 4: Organs on a chip:

Introduction to tissue engineering, tissue under flow, organ-organ interaction. 

Week 5: Organoids:

What are organoids? Fabrication, benefits and limitations  

Week 6: 2D vs. 3D:

Cell properties in 2D vs. 3D. microenvironment, cell mechanics, limitation, overview of different 2 and 3D models. 

Week 7: Artificial organs:

Introduction to artificial organs, requirements, engineering and creating artificial organs, 3D printing, scaffolds. 

Week 8: In vitro metrics  

Assessing the in vitro samples, readouts, clinical relevance 

Week 9: Sensors

Scaling sensors to cellular readouts, type of transducers, fabrication, limitations.

Week 10: Applications to basic research and drug development

How biomimetic systems can be applied in drug development. The drug development process, limitations of the process, what is the strength and limitations of the biomimetic systems in drug development.         

Week 11: In vitro in vivo extrapolation (IVIVE)

Cellularity, scaling microsystems to human scale, translation of the system to clinical data

Week 12 Summarizing lecture and outlook 

Literature and preparations

Specific prerequisites *

Recommendation:

The course content is tuned for M.Sc. and PhD students in the field of bioengineering and bioelectrical engineering but can be relevant for M.Sc. and PhD students in material science, biotechnology, cell physics, biology and similar study directions.

Recommended prerequisites

No information inserted

Equipment

Videoconference system

Literature

Scientific literature

Examination and completion

If the course is discontinued, students may request to be examined during the following two academic years.

Grading scale *

P, F

Examination *

  • EXA1 - Examination, 6.0 credits, Grading scale: P, F

Based on recommendation from KTH’s coordinator for disabilities, the examiner will decide how to adapt an examination for students with documented disability.

The examiner may apply another examination format when re-examining individual students.

  • A lecture 40%
  • A review on the topic 40%
  • A multiple-choice exam 20%

Other requirements for final grade *

  • 80% attendance in class
  • Each student will have to prepare a lecture (as part of a group) – preferably mixed groups between the universities
  • Each student will have to prepare a review on the topic he chooses (as part of a group) – preferably mixed groups between the universities
  • All students are expected to be active participants during the meeting

Opportunity to complete the requirements via supplementary examination

No information inserted

Opportunity to raise an approved grade via renewed examination

No information inserted

Examiner

Anna Herland

Ethical approach *

  • All members of a group are responsible for the group's work.
  • In any assessment, every student shall honestly disclose any help received and sources used.
  • In an oral assessment, every student shall be able to present and answer questions about the entire assignment and solution.

Further information

Course web

Further information about the course can be found on the Course web at the link below. Information on the Course web will later be moved to this site.

Course web FJQ3110

Offered by

EECS/Micro and Nano Systems

Main field of study *

No information inserted

Education cycle *

Third cycle

Add-on studies

No information inserted

Postgraduate course

Postgraduate courses at EECS/Micro and Nano Systems