Intended learning outcomes *
After completing the course, the student should be able to:
• Reflect over the need for and limitations of systems mimicking and predicting human physiology
• Understand the critical components of biomimetic systems
• Understand the basic principles in microfluidics and be able to describe material options and fabrication processes
• Understand the differences in vitro models including Organ Chips, Organoid cultures, other 3D cell cultures and conventional cell cultures.
• Analyze the needs for analytical readouts of biomimetic systems and understand different sensing principles that are compliable with the technologies
• Understand the basic principles in extrapolations of in vitro data to human in vivo physiology
• Analyse and reflect over the use of biomimetic systems in drug development and clinical settings
• Analyze and discuss the scientific literature in biomimetic systems
• Analyze and reflect over the sustainability aspects of Biomimetic systems, in particular the aspects of environmental and societal impact of both the current status of the studies and future dissemination of the technology
The course is organized as lecture series, consisting of 12 number of lectures combined with seminars where the student will present and discuss their project works. The lecture and seminar series will be shared between the universities as web conferences. The participants of the course will be divided in groups with at least two participants from each university. The groups will be given a topic for in depth studies of relevant scientific literature. This project work will be presented as a seminar and a review.
Preliminary detailed syllabus:
Week 1: The needs for and challenges of mimicking the human physiology:
Why we should build systems that mimic the human physiology? introduction to physiology, How the human physiology is different from other animals
Week 2: Introduction to in vitro systems:
Overview of in vitro system, what are their benefits and limitations
Week 3: Microfluidic systems:
Introduction to microfluidics, flow, fabrication, materials
Week 4: Organs on a chip:
Introduction to tissue engineering, tissue under flow, organ-organ interaction.
Week 5: Organoids:
What are organoids? Fabrication, benefits and limitations
Week 6: 2D vs. 3D:
Cell properties in 2D vs. 3D. microenvironment, cell mechanics, limitation, overview of different 2 and 3D models.
Week 7: Artificial organs:
Introduction to artificial organs, requirements, engineering and creating artificial organs, 3D printing, scaffolds.
Week 8: In vitro metrics
Assessing the in vitro samples, readouts, clinical relevance
Week 9: Sensors
Scaling sensors to cellular readouts, type of transducers, fabrication, limitations.
Week 10: Applications to basic research and drug development
How biomimetic systems can be applied in drug development. The drug development process, limitations of the process, what is the strength and limitations of the biomimetic systems in drug development.
Week 11: In vitro in vivo extrapolation (IVIVE)
Cellularity, scaling microsystems to human scale, translation of the system to clinical data
Week 12 Summarizing lecture and outlook