KD1090 Organic Chemistry 1 7.5 credits

• Basic principles in organic chemistry
• Structure and reactivity
• Stereochemistry
• Acidity-basicity
• Molecular orbitals
• Structural analysis
• Substitution, elimination
• Addition to double bonds
• Hydroboration
• Alcohols
• Carbonyl chemistry

The laboratory course covers: organic reactions, extraction, distillation, crystallisation, chromatography, NMR, IR.

Course objectives for the theoretical part 

The student who has achieve a pass grading in the exam is expected to master the following:

• Name organic compounds according to the IUPAC nomenclature
• Know the trivial names for common organic compounds
• Draw bond line formulas for a given organic compound
• Graphically visualize organic reactions with correct reaction mechanisms
• Show how rotation around single bonds interconverts conformations and discuss the related energetics in a qualitative manner
• Describe how organic compounds extend in three dimensions and the consequences thereof and discus this three-dimensional behavior with concepts such as chirality, enantiomer, absolute configuration, diastereomer and meso form
• Recognize how some organic compounds as pharmaceutical active ingredients (API) in some important drugs influence health of individuals and economy for companies and the society
• Use the concepts nucleophile and electrophile in order to explain the reactivity and the role of reactants in a chemical reaction
• Use a simplified molecular orbital concept to identify HOMO and LUMO of organic molecules
• Rank different HOMOs and LUMOs for nucleophiles and electrophiles depending on their relative enrgies and thereby establish their relative reactivity order
• Explain the connotation of reaction mechanism arrows within an electrostatic or molecular orbital point of view
• Explain and visualize the stereochemical (and eventual regiochemical) outcome for some common and important organic reactions as SN2, E2, SN1, E1, addition of electrophiles to alkenes and some additions of nucleophiles to a number of representative carbonyl compounds
• Explain how hydrogen bonds may influence reactivity of a given nuclephile
• Explain the very important role of proton transfer in organic chemistry

Course objectives for the laboratory part

The student who has performed the laboratory part of the course with a pass grading is expected to have acquired knowledge and skill of the following:

• How to perform laboratory work in safe and tidy manner
• How to separate different compound with respect to their solubility in water and organic solvents depending on pH
• How to turn a recipe to a successfully completed synthesis and understand the chemical principles behind
• How to follow a reaction with help of TLC
• How to purify an organic compound by way of distillation, recrystallization or chromatography
• How to carry through a work-up procedure for a reaction
• How to, in principle, determine structure and how to characterize organic compounds with help of NMR, IR and GC

Completed upper secondary education including documented proficiency in English corresponding to English A. For students who received/will receive their final school grades after 31 December 2009, there is an additional entry requirement for mathematics as follows: documented proficiency in mathematics corresponding to Mathematics A.

And the specific requirements of mathematics, physics and chemistry corresponding to Mathematics E, Physics B and Chemistry A.

KD1020 Introductory chemistry, or equivalent

• A. Burrows, A. Parsons, G.Price; Chemistry 3: Introducing Inorganic, Organic and Physical Chemistry, 
  Oxford University Press, USA, 2009,
  ISBN10: 0199277893
  ISBN13: 9780199277896
• Safety compendium, Organic Chemistry , KTH
• Laboratory compendium, Organic Chemistry , KTH

If the course is discontinued, students may request to be examined during the following two academic years.

• LAB1 - Laboratory Work, 3.0 credits, grading scale: P, F
• TEN1 - Examination, 4.5 credits, grading scale: A, B, C, D, E, FX, F

Based on recommendation from KTH’s coordinator for disabilities, the examiner will decide how to adapt an examination for students with documented disability.

The examiner may apply another examination format when re-examining individual students.

Examination (TEN1), 4,5 credits
Laboratory course (LAB1), 3 credits

Olof Ramström

Peter Dinér

• All members of a group are responsible for the group's work.
• In any assessment, every student shall honestly disclose any help received and sources used.
• In an oral assessment, every student shall be able to present and answer questions about the entire assignment and solution.

KD1100 Organic Chemistry 2

Will replace 3B1750

Replaced by the course KD1230