KD2400 Bioactive Molecules 6.0 credits

Bioaktiva molekyler

Course on bioactive molecules, including their chemical characterization and mechanisms of action. The aim of the course is to work with natural products and give students experience in practical use of preparative and analytical separation methods including GC-MS and LC andLC-MS. Bioactivity of fractions obtained will be tested on various organisms such as insects and microbes.  

Offering and execution

Course offering missing for current semester as well as for previous and coming semesters

Course information

Content and learning outcomes

Course contents *

  • Methods how to determine bioactivity
  • Chemical, farmacological, biological tools for determining bioactive molecules
  • The wide structural range of bioactive molecules
  • Natural products as an important area for new lead compounds in the development of new drugs
  • Selected mechanisms of bioactivity, e.g. electrophysiology, ion channels,
  • Applications in pharmacology, chemical ecology,environmental toxicology, atompheric chemistry

Intended learning outcomes *

After the course the student should be able to:

  • Give examples of important areas where bioctive compounds are involved
  • give examples of the diversity in structure and bioactivity
  • follow the general route how to identify bioactive molecules
  • practically use the main instruments for identifying molecules
  • practically use main methods to test bioactivity
  • understand the evolutionary and molecular background for bioactivity (selected cases)
  • evaluate the importance of doses in relation to bioactivity

Course Disposition

Lectures and laboratory work.

Literature and preparations

Specific prerequisites *

Admission requirements for programme students at KTH:
At least 150 credits from grades 1, 2 and 3 of which at least 110 credits from years 1 and 2, and bachelor's work must be completed, within a programme that includes:
75 university credits (hp) in chemistry or chemical engineering, 20 university credits (hp) in mathematics and 6 university credits (hp) in computer science or corresponding.

Admission requirements for independent students:
75 university credits (hp) in chemistry or chemical engineering, 20 university credits (hp) in mathematics and 6 university credits (hp) in computer science or corresponding. Documented proficiency in English corresponding to English B.

Recommended prerequisites

basic level organic chemistry, analytical chemistry

Equipment

No information inserted

Literature

To be announced at the latest three weeks before the course starts.
Handouts

Examination and completion

Grading scale *

A, B, C, D, E, FX, F

Examination *

  • LAB1 - Laboratory Work, 1.5 credits, Grading scale: P, F
  • PRO1 - Project Work, 1.0 credits, Grading scale: P, F
  • TEN1 - Examination, 3.5 credits, Grading scale: A, B, C, D, E, FX, F

Based on recommendation from KTH’s coordinator for disabilities, the examiner will decide how to adapt an examination for students with documented disability.

The examiner may apply another examination format when re-examining individual students.

All presentations within the project work and all laboratory work is mandatory.

Other requirements for final grade *

Project work (PRO1; 1 credits)
Examination (TEN1; 3.5 credits) 
Laboratory work (LAB1; 1.5 credits)

The final grade will be the same as for the examination

Opportunity to complete the requirements via supplementary examination

No information inserted

Opportunity to raise an approved grade via renewed examination

No information inserted

Examiner

Anna Karin Borg Karlsson

Further information

Course web

Further information about the course can be found on the Course web at the link below. Information on the Course web will later be moved to this site.

Course web KD2400

Offered by

CHE/Chemistry

Main field of study *

Biotechnology, Chemical Science and Engineering

Education cycle *

Second cycle

Add-on studies

No information inserted

Ethical approach *

  • All members of a group are responsible for the group's work.
  • In any assessment, every student shall honestly disclose any help received and sources used.
  • In an oral assessment, every student shall be able to present and answer questions about the entire assignment and solution.

Supplementary information

The course is replaced by KD2401