Class information for:
Level 2: EZH2//CHROMATIN//POLYCOMB

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
343 17754 49.7 92%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
71 3       GENETICS & HEREDITY//CHROMATIN//CELL BIOLOGY 83302
343 2             EZH2//CHROMATIN//POLYCOMB 17754
1710 1                   EZH2//POLYCOMB//BMI 1 2524
3273 1                   NUCLEOSOME POSITIONING//ISWI//NUCLEOSOME 2022
4702 1                   CHIP SEQ//ENHANCER//PEAK CALLING 1741
5093 1                   HISTONE CHAPERONE//HISTONE VARIANTS//ASF1 1674
5481 1                   ARGININE METHYLATION//PROTEIN ARGININE METHYLTRANSFERASE//PRMT 1618
6164 1                   RHABDOID TUMOR//ATYPICAL TERATOID RHABDOID TUMOR//MALIGNANT RHABDOID TUMOR 1519
8082 1                   HISTONE DEMETHYLASE//LSD1//HISTONE DEMETHYLATION 1295
8607 1                   HISTONE ACETYLTRANSFERASE//GCN5//MOZ 1236
12023 1                   SET8//HISTONE//PR SET7 937
13694 1                   BROMODOMAIN//BRD4//NUT MIDLINE CARCINOMA 819
14125 1                   USP22//SET1//UBIQUITIN SPECIFIC PROTEASE 22 791
17131 1                   MTA1//CHD5//METASTASIS ASSOCIATED GENE 1 616
21151 1                   ING1//ING4//P33ING1 431
24211 1                   BRMS1//BREAST CANCER METASTASIS SUPPRESSOR 1//SIN3 320
31526 1                   ARID3B//JUMONJI//AT RICH INTERACTION DOMAIN 151
37377 1                   RSF 1//HBXAP//BASIC SCI INT HLTH 60

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 EZH2 authKW 397786 2% 65% 356
2 CHROMATIN authKW 349649 6% 20% 1026
3 POLYCOMB authKW 262319 2% 57% 270
4 RHABDOID TUMOR authKW 219318 1% 76% 168
5 BROMODOMAIN authKW 189975 1% 75% 148
6 SWI SNF authKW 182159 1% 63% 168
7 ATYPICAL TERATOID RHABDOID TUMOR authKW 176440 1% 81% 127
8 HISTONE authKW 176248 3% 22% 475
9 HISTONE DEMETHYLASE authKW 173992 1% 71% 142
10 NUCLEOSOME authKW 152331 2% 29% 306

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 Cell Biology 71098 33% 1% 5860
2 Biochemistry & Molecular Biology 56836 48% 1% 8438
3 Genetics & Heredity 25880 17% 1% 2997
4 Oncology 12030 15% 0% 2701
5 Developmental Biology 9409 5% 1% 883
6 Biochemical Research Methods 4373 6% 0% 1090
7 Biophysics 2881 6% 0% 1011
8 Biotechnology & Applied Microbiology 2316 6% 0% 1120
9 Mathematical & Computational Biology 1909 2% 0% 393
10 Pathology 1863 4% 0% 638

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class
1 STRUCT GENOM CONSORTIUM 90949 1% 25% 212
2 CHROMATIN BIOL 35599 0% 36% 58
3 CHROMATIN BIOL EPIGENET 32295 0% 47% 40
4 BIOCHEM MOL BIOL 25818 6% 1% 1108
5 ADOLF BUTENANDT 25640 1% 16% 93
6 EPIGENET PROGRAM 25526 0% 34% 44
7 EPIGENET 24157 1% 13% 107
8 EPINOVA DPU 22345 0% 52% 25
9 INTEGRAT CHEM BIOL DRUG DISCOVERY 20180 0% 37% 32
10 CHROMATIN GENE EXP S SECT 19616 0% 57% 20

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOLECULAR CELL 47356 2% 7% 390
2 EPIGENETICS & CHROMATIN 45911 0% 30% 88
3 MOLECULAR AND CELLULAR BIOLOGY 37449 4% 3% 705
4 GENES & DEVELOPMENT 24340 2% 4% 328
5 GENOME RESEARCH 19937 1% 9% 127
6 EPIGENOMICS 16085 0% 14% 66
7 NATURE STRUCTURAL & MOLECULAR BIOLOGY 14903 1% 6% 138
8 BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 13422 1% 9% 91
9 NUCLEIC ACIDS RESEARCH 11473 3% 1% 532
10 CELL 9851 2% 2% 300

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with term
in class		 LCSH search Wikipedia search
1 EZH2 397786 2% 65% 356 Search EZH2 Search EZH2
2 CHROMATIN 349649 6% 20% 1026 Search CHROMATIN Search CHROMATIN
3 POLYCOMB 262319 2% 57% 270 Search POLYCOMB Search POLYCOMB
4 RHABDOID TUMOR 219318 1% 76% 168 Search RHABDOID+TUMOR Search RHABDOID+TUMOR
5 BROMODOMAIN 189975 1% 75% 148 Search BROMODOMAIN Search BROMODOMAIN
6 SWI SNF 182159 1% 63% 168 Search SWI+SNF Search SWI+SNF
7 ATYPICAL TERATOID RHABDOID TUMOR 176440 1% 81% 127 Search ATYPICAL+TERATOID+RHABDOID+TUMOR Search ATYPICAL+TERATOID+RHABDOID+TUMOR
8 HISTONE 176248 3% 22% 475 Search HISTONE Search HISTONE
9 HISTONE DEMETHYLASE 173992 1% 71% 142 Search HISTONE+DEMETHYLASE Search HISTONE+DEMETHYLASE
10 NUCLEOSOME 152331 2% 29% 306 Search NUCLEOSOME Search NUCLEOSOME

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 RANDO, OJ , WINSTON, F , (2012) CHROMATIN AND TRANSCRIPTION IN YEAST.GENETICS. VOL. 190. ISSUE 2. P. 351-387 392 73% 80
2 MCGRATH, J , TROJER, P , (2015) TARGETING HISTONE LYSINE METHYLATION IN CANCER.PHARMACOLOGY & THERAPEUTICS. VOL. 150. ISSUE . P. 1 -22 217 67% 39
3 VENKATESH, S , WORKMAN, JL , (2015) HISTONE EXCHANGE, CHROMATIN STRUCTURE AND THE REGULATION OF TRANSCRIPTION.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 16. ISSUE 3. P. 178 -189 129 83% 92
4 KOOISTRA, SM , HELIN, K , (2012) MOLECULAR MECHANISMS AND POTENTIAL FUNCTIONS OF HISTONE DEMETHYLASES.NATURE REVIEWS MOLECULAR CELL BIOLOGY. VOL. 13. ISSUE 5. P. 297-311 162 82% 233
5 BOWMAN, GD , POIRIER, MG , (2015) POST-TRANSLATIONAL MODIFICATIONS OF HISTONES THAT INFLUENCE NUCLEOSOME DYNAMICS.CHEMICAL REVIEWS. VOL. 115. ISSUE 6. P. 2274 -2295 234 69% 22
6 HU, H , QIAN, K , HO, MC , ZHENG, YG , (2016) SMALL MOLECULE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASES.EXPERT OPINION ON INVESTIGATIONAL DRUGS. VOL. 25. ISSUE 3. P. 335 -358 175 81% 6
7 SIMON, JA , KINGSTON, RE , (2013) OCCUPYING CHROMATIN: POLYCOMB MECHANISMS FOR GETTING TO GENOMIC TARGETS, STOPPING TRANSCRIPTIONAL TRAFFIC, AND STAYING PUT.MOLECULAR CELL. VOL. 49. ISSUE 5. P. 808 -824 126 82% 244
8 LI, B , CAREY, M , WORKMAN, JL , (2007) THE ROLE OF CHROMATIN DURING TRANSCRIPTION.CELL. VOL. 128. ISSUE 4. P. 707 -719 101 81% 1694
9 WANG, W , QIN, JJ , VORUGANTI, S , NAG, S , ZHOU, JW , ZHANG, RW , (2015) POLYCOMB GROUP (PCG) PROTEINS AND HUMAN CANCERS: MULTIFACETED FUNCTIONS AND THERAPEUTIC IMPLICATIONS.MEDICINAL RESEARCH REVIEWS. VOL. 35. ISSUE 6. P. 1220 -1267 242 77% 3
10 KIM, KH , ROBERTS, CWM , (2016) TARGETING EZH2 IN CANCER.NATURE MEDICINE. VOL. 22. ISSUE 2. P. 128 -134 92 79% 36

Classes with closest relation at Level 2


Rank Class id link
1 3263 CTCF//CONTROL GENET PROC//NF Y
2 3084 CHROMOSOME TERRITORY//NUCLEAR ARCHITECTURE//NUCLEAR ORGANIZATION
3 1094 NUCLEAR MATRIX//LINKER HISTONE//HISTONE H1
4 2504 TFIID//RNA POLYMERASE II//MEDIATOR COMPLEX
5 1531 HISTONE DEACETYLASE INHIBITOR//HISTONE DEACETYLASE//HDAC INHIBITOR
6 382 DNA METHYLATION//EPIGENETICS//METHYLATION
7 3833 CITED2//BRANCHIO OCULO FACIAL SYNDROME//AP 2 ALPHA
8 2682 DNA REPLICATION//GEMININ//CDC6
9 1227 TRANSPOSABLE ELEMENTS//RETROTRANSPOSON//CHROMOSOMA
10 2649 SIRT1//SIRTUINS//SIRT3

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