BB2560 Advanced Microbiology and Metagenomics 7.5 credits

Avancerad mikrobiologi och metagenomik

This course provides training on the methods used for microbial community analysis including recent innovations in metagenomics, metatranscriptomics, metaproteomics, and functional metagenomics. Students will investigate a series of case studies of meta-omics analysis of environmental and human-associated microbial communities.

  • Education cycle

    Second cycle
  • Main field of study

    Biotechnology
  • Grading scale

    A, B, C, D, E, FX, F

Course offerings

Spring 19 for programme students

Spring 20 for programme students

Intended learning outcomes

After passing the course, the student shall demonstrate profound understanding of selected microbial ecosystems and be able to design experiments and use meta-analysis in different microbiology applications such as:

•                     Explain and investigate the roles of microbes in natural ecosystems 

•                     Explain the roles of the human microbiota in health and disease

•                     Describe how metagenomics can be used to diagnose environmental and human health

•                     Discuss the societal and scientific challenges with antimicrobial resistance

•                     Explain how pathogen identification is conducted in the clinic

•                     Plan and conduct a microbial community analysis, with discussion of safe sample handling and ethical concerns

•                     Explain how metagenomics can be used for enzyme discovery

Course main content

Recent years have seen an explosion of large datasets generated on microbial communities in natural and industrial environments, thanks to advances in metagenomics and related technologies. These new data can give insight into human health and disease, or the fitness of a natural environment. In addition, these data can inform biotechnological interventions into the microbiota for improved digestion or food production, or can be a source of new industrially relevant enzymes.

Disposition

The course will cover five key themes:

T1. Introduction to microbial communities and metagenomics

T2. Microbes in nature - oceans, lakes and soil

T3. The human microbiome

T4. Antimicrobial resistance

T5. Enzyme discovery through meta-omics

Eligibility

Literature

Scientific articles, web resources, and lecture handouts will be provided during the course. Course book(s), if any, will be posted on the web site of the course at least four weeks prior to course start.

Examination

  • LAB1 - Laboratory course, 2.5, grading scale: P, F
  • TEN1 - Examination, 4.0, grading scale: A, B, C, D, E, FX, F
  • ÖVN1 - Exercise, 1.0, grading scale: P, F

Offered by

CBH/Gene Technology

Contact

Lauren McKee, mckee@kth.se, tel. 08-790 96 99

Examiner

Anders Andersson <andand@kth.se>

Version

Course syllabus valid from: Spring 2019.
Examination information valid from: Spring 2019.