BB2560 Advanced Microbiology and Metagenomics 7.5 credits

Avancerad mikrobiologi och metagenomik

This course provides training on the methods used for microbial community analysis including recent innovations in metagenomics, metatranscriptomics, metaproteomics, and functional metagenomics. Students will investigate a series of case studies of meta-omics analysis of environmental and human-associated microbial communities.

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Course information

Content and learning outcomes

Course contents *

Recent years have seen an explosion of large datasets generated on microbial communities in natural and industrial environments, thanks to advances in metagenomics and related technologies. These new data can give insight into human health and disease, or the fitness of a natural environment. In addition, these data can inform biotechnological interventions into the microbiota for improved digestion or food production, or can be a source of new industrially relevant enzymes.
The course will cover five key themes:

T1. Introduction to microbial communities and metagenomics

T2. Microbes in nature - oceans, lakes and soil

T3. The human microbiome

T4. Antimicrobial resistance

T5. Enzyme discovery through meta-omics

Intended learning outcomes *

After passing the course, the student shall demonstrate profound understanding of selected microbial ecosystems and be able to design experiments and use meta-analysis in different microbiology applications. The specific learning objectives are to be able to:

  • Explain and investigate the roles of microbes in natural ecosystems
  • Explain the roles of the human microbiota in health and disease
  • Describe how metagenomics can be used to diagnose environmental and human health
  • Discuss the societal and scientific challenges with antimicrobial resistance
  • Plan and conduct a microbial community analysis, including a full work-flow from sampling to DNA extraction and in silico data analysis, with discussion of safe sample handling and ethical concerns,
  • Explain how metagenomics can be used for enzyme discovery.

Course Disposition

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Literature and preparations

Specific prerequisites *

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Recommended prerequisites

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Equipment

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Literature

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Examination and completion

Grading scale *

A, B, C, D, E, FX, F

Examination *

  • LAB1 - Laboratory course, 2.5 credits, Grading scale: P, F
  • TEN1 - Examination, 4.0 credits, Grading scale: A, B, C, D, E, FX, F
  • ÖVN1 - Exercise, 1.0 credits, Grading scale: P, F

Based on recommendation from KTH’s coordinator for disabilities, the examiner will decide how to adapt an examination for students with documented disability.

The examiner may apply another examination format when re-examining individual students.

Some lectures will be mandatory as they will involve student assessment tasks. Students who are unable to attend these compulsory lectures will be asked to submit alternative written assignments.

Other requirements for final grade *

Students are required to PASS the LAB1 assignment (lab report) and to PASS the in-class exercises (OVN1) in order to pass the course. Students are also required to PASS the final exam (TEN1) to pass the course.
The final grade a student achieves is determined by their result on TEN1.

Opportunity to complete the requirements via supplementary examination

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Opportunity to raise an approved grade via renewed examination

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Examiner

Anders Andersson

Further information

Course web

Further information about the course can be found on the Course web at the link below. Information on the Course web will later be moved to this site.

Course web BB2560

Offered by

CBH/Gene Technology

Main field of study *

Biotechnology

Education cycle *

Second cycle

Add-on studies

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Contact

Lauren McKee, mckee@kth.se, tel. 08-790 96 99

Ethical approach *

  • All members of a group are responsible for the group's work.
  • In any assessment, every student shall honestly disclose any help received and sources used.
  • In an oral assessment, every student shall be able to present and answer questions about the entire assignment and solution.