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KD2390 Selective Organic Synthesis 9.0 credits

Selective Organic Synthesis (KD2390) is an advanced master level course in organic chemistry tand a continuation of Advanced Organic Chemistry (KD2310). The course aims at widen and deepen the students' knowledge and understanding of modern organic synthesis, including light- and electricity driven synthesis. The course covers fundamental concepts in chemo-, regio- and stereoselectivity and apply these in synthetic strategies. In addition, the course covers retrosynthetic analysis that aims at enabling advanced organic synthesis from simple molecular building blocks. KD2390 (9.0 hp) countains lab work equivalent to 1.5 hp, but is otherwise identical to the course CE2385 (7.5 hp). These courses are mutually exclusive and only one of them may be included in a diploma degree.

 

Please note that from the fall semester 2024 the course KD2390 will be replaced with the course CK2390 with closely related course content.

Choose semester and course offering

Choose semester and course offering to see current information and more about the course, such as course syllabus, study period, and application information.

Headings with content from the Course syllabus KD2390 (Autumn 2024–) are denoted with an asterisk ( )

Content and learning outcomes

Course contents

  • Fundamental concepts in chemo-, regio-, and stereoselectivity
  • Synthetic strategy and principles for selective, in particular stereoselective, chemical transformations
  • Transition metal catalysis
  • Frontier orbital-controlled reactions
  • Retrosynthetic analysis
  • Advanced organic synthesis

Intended learning outcomes

After passing the course the student should be able to:

  • Explain basic chemo-, regio-, and stereoselective concepts and apply these in synthesis, as well as construct reactions pathways of complex organic compounds using retrosynthetic analysis.
  • Apply synthesis methodology to perform advanced organic synthesis.

Course disposition

No information inserted

Literature and preparations

Specific prerequisites

At least 150 credits from grades 1, 2 and 3 of which at least 110 credits from years 1 and 2, and bachelor's work must be completed, within a programme that includes:

75 university credits (hp) in chemistry or chemical engineering, 20 university credits (hp) in mathematics and 9 university credits (hp) in computer science or corresponding.

Recommended prerequisites

1st cycle courses in organic chemistry (e.g., KD1090/KD1230 and KD1100/KD1270), and 2nd cycle course in organic chemistry KD2310 (can be studied in parallel), or equivalent courses.

Equipment

No information inserted

Literature

Clayden, Greeves and Warren Organic Chemistry, Oxford University Press, 2012 (ISBN 978-0-19-927029-3)and hand-out material

Examination and completion

If the course is discontinued, students may request to be examined during the following two academic years.

Grading scale

A, B, C, D, E, FX, F

Examination

  • LAB1 - Laboratory Work, 2.5 credits, grading scale: P, F
  • TEN1 - Examination, 6.5 credits, grading scale: A, B, C, D, E, FX, F

Based on recommendation from KTH’s coordinator for disabilities, the examiner will decide how to adapt an examination for students with documented disability.

The examiner may apply another examination format when re-examining individual students.

Other requirements for final grade

The final grade will be the same as for the examination

Opportunity to complete the requirements via supplementary examination

No information inserted

Opportunity to raise an approved grade via renewed examination

No information inserted

Examiner

Ethical approach

  • All members of a group are responsible for the group's work.
  • In any assessment, every student shall honestly disclose any help received and sources used.
  • In an oral assessment, every student shall be able to present and answer questions about the entire assignment and solution.

Further information

Course web

Further information about the course can be found on the Course web at the link below. Information on the Course web will later be moved to this site.

Course web KD2390

Offered by

Main field of study

Chemical Science and Engineering

Education cycle

Second cycle

Add-on studies

No information inserted

Transitional regulations

The students must contact the examiner for information about the laboratories.

Module (LAB1) – Laboratory modules can be completed on at least one and up to two occasions during the next two years (ie once a year or once every two years) after the course has been taught for the last time.

Module (TEN1) - Written exam is offered four times in the next two years (ie twice per year) after the course is given for the last time.

A new course with the course code CK2390 is being established, which will have the following module division from Autmn 2024

LAB1 - Laborations/Laborations, 2.5 credits, grading scale: P, F

TEN1 – Written exam/Written exam, 5 credits, grading scale: A, B, C, D, E, Fx, F

Supplementary information

The course KD2390 includes a theoretical part, which is identical to the course CE2385 Selecive Organic Synthesis, theory.
Only one of the courses above can be included in the diploma.