SK2512 Cellular Biophysics 10.0 credits

Cellulär biofysik

Models and equations describing the transport of water, ions and nutrients within cells and through cell membranes. Active and passive transport. Channels and carriers. Cell electrical potential (graded and action potential). Methods for measuring cellular physical parameters.

  • Education cycle

    Second cycle
  • Main field of study

    Biotechnology
    Engineering Physics
    Physics
  • Grading scale

    A, B, C, D, E, FX, F

Course offerings

Spring 19 for programme students

Spring 19 SAP for Study Abroad Programme (SAP)

  • Periods

    Spring 19 P3 (5.0 credits), P4 (5.0 credits)

  • Application code

    20032

  • Start date

    15/01/2019

  • End date

    04/06/2019

  • Language of instruction

    English

  • Campus

    AlbaNova

  • Tutoring time

    Daytime

  • Form of study

    Normal

  • Number of places *

    Max. 5

    *) If there are more applicants than number of places selection will be made.

  • Schedule

    Schedule (new window)

  • Course responsible

    Hjalmar Brismar <brismar@kth.se>

  • Teacher

    Hjalmar Brismar <brismar@kth.se>

    Marina Zelenina <marinaz@kth.se>

  • Target group

    UCAS

Spring 19 SAP for programme students CANCELLED

  • Periods

    Spring 19 P3 (5.0 credits), P4 (5.0 credits)

  • Application code

    60912

  • Start date

    15/01/2019

  • End date

    04/06/2019

  • Language of instruction

    English

  • Campus

    AlbaNova

  • Tutoring time

    Daytime

  • Form of study

    Normal

  • Number of places *

    Max. 5

    *) If there are more applicants than number of places selection will be made.

  • Schedule

    Schedule (new window)

  • Course responsible

    Hjalmar Brismar <brismar@kth.se>

  • Teacher

    Hjalmar Brismar <brismar@kth.se>

    Marina Zelenina <marinaz@kth.se>

  • Target group

    UCAS

Spring 20 for programme students

Intended learning outcomes

Upon completion of the course, students should be able to:

  • describe the basic physical principles of cell function in transport of water, ions and nutrients
  • define mathematical models for transport of water, ions and solutes in and across the cell membrane
  • describe how the cell regulates water and ion balance and how it is affected by the cell environment
  • calculate the cell membrane potential and how it varies in different situations
  • perform measurements of different cellular physical parameters using microscope-based methods

Course main content

Models and equations describing the transport of water, ions and nutrients within cells and through cell membranes. Active and passive transport. Channels and carriers. Cell electrical potential (graded and action potential). Methods for measuring cellular physical parameters.

Lectures (24 hours), laboratory exercises (32 hours), hand-in assignment

Laboratory exercises:

  • measurement of diffusion in an aqueous solution that mimics cytoplasm (fluorescent microscopy)
  • measurement of diffusion in cell membranes (living cells, confocal microscopy)
  • measurement of changes in cell volume (living cells, confocal microscopy)
  • measurement of changes in cell membrane potential (living cells, confocal microscopy)

Eligibility

Basic knowledge of mathematics (differential and integral calculus, linear algebra, differential equations) and physics (classical physics, electromagnetism).

Recommended prerequisites

Basic knowledge of mathematics (differential and integral calculus, linear algebra, differential equations) and physics (classical physics, electromagnetism).

Literature

Weiss TF. Cellular Biophysics, vol 1: Transport, MIT Press, 1996

Weiss TF. Cellular Biophysics, vol 2: Electrical properties, MIT Press, 1997

Examination

  • INL1 - Hand in assignment, 1.0, grading scale: P, F
  • LAB1 - Laboratory experiments, 4.0, grading scale: P, F
  • TEN1 - Written exam, 5.0, grading scale: A, B, C, D, E, FX, F

Requirements for final grade

Hand-in assignment (INL1 1,0 credits, grade scale: P, F)

Laboratory exercises (LAB1 4,0 credits, grade scale: P, F)

Written exam (TEN1 5,0 credits, grade scale: A, B, C, D, E, FX, F)

Offered by

SCI/Applied Physics

Contact

Hjalmar Brismar (brismar@kth.se)

Examiner

Hjalmar Brismar <brismar@kth.se>

Supplementary information

Replaces SK2510 och SK2511

Version

Course syllabus valid from: Spring 2019.
Examination information valid from: Spring 2019.