Hjalmar Brismar
PROFESSOR
Details
Researcher
About me
Understanding Cellular Dynamics
Our research group investigates the fundamental physical principles that govern biological processes at the cellular level. We seek to understand the cell's complex energy landscape and how protein interactions contribute to integrated physiological functions and organismal diversity.
A central focus of our research is the Na,K-ATPase, a vital ion pump responsible for intracellular homeostasis. We have pioneered the field of Na,K-ATPase signaling, elucidating how the endogenous ligand ouabain triggers intracellular calcium oscillations. These signals have been demonstrated to play critical roles in cellular stress response, including protection against apoptosis in various pathological conditions.
Current projects explore topics such as the Na,K-ATPase catalytic subunit's allosteric regulation, interactions between Na,K-ATPase and IP3R, and functional oligomerization of the pump. Advanced imaging techniques are integral to our research methodology.
We are leaders in microscopy innovation, developing super-resolution and hyperfast volume imaging methods. Our group operates the national super-resolution microscopy infrastructure at the Science for Life Laboratory. Additionally, we coordinate the National Microscopy Infrastructure (NMI) https://www.nmisweden.se and represent the Swedish node in EurobioImaging https://www.eurobioimaging.eu.
Our team fosters a cross-disciplinary environment, with members from KTH and Karolinska Institutet. We integrate advanced light microscopy with cell and molecular biology approaches to advance our understanding of life's fundamental processes.
Interested in joining our team or collaborating? Contact me at
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Short CV
1991 CivIng, Engineering Physics, KTH
1996 PhD, Engineering Physics, KTH
1996 Postdoctoral Research Fellow, Biomedical Imaging Laboratory, Harvard University
1997 Assistant professor, Dept of Women’s and Children’s Health, Karolinska Institutet
2002 Docent in Experimental Pediatrics, KI
2003-2012 Guest Professor, Dept of Women’s and Children’s Health, KI
2003- Professor of Exp. Biological Physics, Dept of Applied Physics, KTH
2010- Director for Cellular and Molecular Imaging Platform, Science for Life Laboratory
Supervision
Supervised 15 PhDs, 8 Lic, and 48 M.Sc thesis.
Supervised 16 postdocs.
Awards and distinctions
2010 elected member of Royal Swedish Academy of Engineering Sciences, (IVA)
2009- member of the National committee for Molecular Biosciences, KVA (chair 2012-2017)
2007 SDA distinguished paper award
2002 Sven och Ebba-Christina Hagbergs prize in medicine
Courses
Basic Modeling in Biotechnology (SI1410), course responsible | Course web
Biomedicine for Engineers (FSK3532), examiner, course responsible | Course web
Cellular Biophysics (SK2535), examiner, course responsible, teacher | Course web
Degree Project in Applied Physics, Second Cycle (SK202X), examiner | Course web
Fundamental Physics I (SK1150), teacher | Course web
New Super-resolution, Light-sheet, and FCS methods at Scilifelab (FSK3534), examiner, course responsible, teacher | Course web