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Course presentation
Selective Organic Synthesis (KD2390) is an advanced master level course in organic chemistry tand a continuation of Advanced Organic Chemistry (KD2310). The course aims at widen and deepen the students' knowledge and understanding of modern organic synthesis, including light- and electricity driven synthesis. The course covers fundamental concepts in chemo-, regio- and stereoselectivity and apply these in synthetic strategies. In addition, the course covers retrosynthetic analysis that aims at enabling advanced organic synthesis from simple molecular building blocks. KD2390 (9.0 hp) countains lab work equivalent to 1.5 hp, but is otherwise identical to the course CE2385 (7.5 hp). These courses are mutually exclusive and only one of them may be included in a diploma degree.
Please note that from the fall semester 2024 the course KD2390 will be replaced with the course CK2390 with closely related course content.
Headings denoted with an asterisk ( * ) is retrieved from the course syllabus version Spring 2020
Content and learning outcomes
Course contents
Fundamental concepts in chemo-, regio-, and stereoselectivity
Synthetic strategy and principles for selective, in particular stereoselective, chemical transformations
Transition metal catalysis
Frontier orbital-controlled reactions
Retrosynthetic analysis
Advanced organic synthesis
Intended learning outcomes
After passing the course the student should be able to:
Explain basic chemo-, regio-, and stereoselective concepts and apply these in synthesis, as well as construct reactions pathways of complex organic compounds using retrosynthetic analysis.
Apply synthesis methodology to perform advanced organic synthesis.
Preparations before course start
Recommended prerequisites
1st cycle courses in organic chemistry (e.g., KD1090/KD1230 and KD1100/KD1270), and 2nd cycle course in organic chemistry KD2310 (can be studied in parallel), or equivalent courses.
Literature
Text book:
Organic Chemistry by Clayden, Greeves & Warren
Oxford University Press, 2012
ISBN: 978-0-19-927029-3
(Bought in campus book store or online book stores)
Primary research literature:
See information for each lecture in Canvas
Support for students with disabilities
Students at KTH with a permanent disability can get support during studies from Funka:
LAB1 - Laboratory Work, 2.5 credits, Grading scale: P, F
TEN1 - Examination, 6.5 credits, Grading scale: A, B, C, D, E, FX, F
Based on recommendation from KTH’s coordinator for disabilities, the examiner will decide how to adapt an examination for students with documented disability.
The examiner may apply another examination format when re-examining individual students.
Other requirements for final grade
The final grade will be the same as for the examination
Opportunity to raise an approved grade via renewed examination
It is not possible to raise an approved grade (plussning).
Ethical approach
All members of a group are responsible for the group's work.
In any assessment, every student shall honestly disclose any help received and sources used.
In an oral assessment, every student shall be able to present and answer questions about the entire assignment and solution.
Further information
Supplementary Information
The course has the same theoretical content as the course KD2390 Selective Organic Synthesis 9,0 hp and the courses share lectures, exercises and seminars.
The lab module LAB1 includes labwork (1.5 hp) and a literature project (1 hp).
Only one of the courses CE2385 and KD2390 may be included in a diploma degree.
