BB2560 Avancerad mikrobiologi och metagenomik 7,5 hp

Advanced Microbiology and Metagenomics

This course provides training on the methods used for microbial community analysis including recent innovations in metagenomics, metatranscriptomics, metaproteomics, and functional metagenomics. Students will investigate a series of case studies of meta-omics analysis of environmental and human-associated microbial communities.

  • Utbildningsnivå

    Avancerad nivå
  • Huvudområde

    Bioteknik
  • Betygsskala

    A, B, C, D, E, FX, F

Kurstillfällen/kursomgångar

VT19 för programstuderande

VT20 för programstuderande

Lärandemål

After passing the course, the student shall demonstrate profound understanding of selected microbial ecosystems and be able to design experiments and use meta-analysis in different microbiology applications such as:

•                     Explain and investigate the roles of microbes in natural ecosystems 

•                     Explain the roles of the human microbiota in health and disease

•                     Describe how metagenomics can be used to diagnose environmental and human health

•                     Discuss the societal and scientific challenges with antimicrobial resistance

•                     Explain how pathogen identification is conducted in the clinic

•                     Plan and conduct a microbial community analysis, with discussion of safe sample handling and ethical concerns

•                     Explain how metagenomics can be used for enzyme discovery

Kursens huvudsakliga innehåll

Recent years have seen an explosion of large datasets generated on microbial communities in natural and industrial environments, thanks to advances in metagenomics and related technologies. These new data can give insight into human health and disease, or the fitness of a natural environment. In addition, these data can inform biotechnological interventions into the microbiota for improved digestion or food production, or can be a source of new industrially relevant enzymes.

Kursupplägg

The course will cover five key themes:

T1. Introduction to microbial communities and metagenomics

T2. Microbes in nature - oceans, lakes and soil

T3. The human microbiome

T4. Antimicrobial resistance

T5. Enzyme discovery through meta-omics

Behörighet

Litteratur

Scientific articles, web resources, and lecture handouts will be provided during the course. Course book(s), if any, will be posted on the web site of the course at least four weeks prior to course start.

Examination

  • LAB1 - Laborationskurs, 2,5, betygsskala: P, F
  • TEN1 - Tentamen, 4,0, betygsskala: A, B, C, D, E, FX, F
  • ÖVN1 - Övning, 1,0, betygsskala: P, F

Ges av

CBH/Genteknologi

Kontaktperson

Lauren McKee, mckee@kth.se, tel. 08-790 96 99

Examinator

Anders Andersson <andand@kth.se>

Versionsinformation

Kursplan gäller från och med VT2019.
Examinationsinformation gäller från och med VT2019.