Henrik Aspeborg
About me
News!!!
Links to other sites where you can read about the Cutibacterium acnes GH5_18 enzyme: KTH, forskning.se and medicalxpress.
Now also a film about our N-glycan feeding Cutibacterium acnes GH5_18 enzyme.
Together with the Divne group we have a new article out in PLoS One describing a Cutibacterium acnes GH5_18 enzyme involved in N-glycan degradation entitled Structural and biochemical characterization of the Cutibacterium acnes exo-β-1,4-mannosidase that targets the N-glycan core of host glycoproteins.
New grant from K E Önnesjös Stiftelse.
The Campus 100 years talk is now available on youtube. Exploring the microbial dark matter of the moose gut for biomass conversion solutions.
The latest article about the moose rumen study was published in Ny Teknik.
You can also read about the identified moose rumen microbes and enzymes in for instance Ingenjören, Aktuell Hållbarhet, and Vi Bilägare.
Vetenskapsradion (Swedish radio) talks about our moose rumen metagenomics project.
A podcast about the moose rumen metagenomics-based research.
The moose rumen metagenomics-based study in the KTH news:
The article "Ninety-nine de novo assembled genomes from the moose (Alces alces) rumen microbiome provide new insights into microbial plant biomass degradation" has been published online in the ISME journal.
Henrik presented the moose rumen microbiome study at the 12th Carbohydrate Bioengineering Meeting, April 23-26, 2017 in Vienna, Austria.
Dayanand Kalyani has joined the group. Welcome!
The moose rumen metagenomics project was presented at a ConverStation during the KTH Sustainability Research Day, 18 okt 2016.
Olov presented results from the moose rumen metagenomics study at the 2nd Symposium on lignin and hemicellulose valorisation by LU Biofuels and EERA Bioenergy, Lund November 3-4, 2015, and at the PolyRefNorth meeting in Ås, November 26-27, 2015.
The article "Biochemical characterization of the novel endo-β-mannanase AtMan5-2 from Arabidopsis thaliana" is out now: doi:10.1016/j.plantsci.2015.10.002
New grant from Formas to support the project "Combining Microbial Enrichment and Metagenomics for Designing Biomass-Degrading Enzyme Cocktails. The project is a joint effort with the Anders Andersson group at KTH/SciLifeLab. more info from Formas
Henrik is now Docent!
This research group now belongs to the Division of Industrial Biotechnology. The homepage of Industrial Biotechnology can be found here.
Principal Investigator (PI) in the Biomass Conversion Biotechnology group
In the Biomass Conversion Biotechnology group we are studying biosynthesis, modification, and degradation of biomass. More specifically we deal with the carbohydrate-active enzymes (CAZymes) involved in these processes. Currently, most target enzymes are plant glycoside hydrolases (GHs), but also non-plant enzymes from glycoside hydrolase family 5 (GH5) are investigated.
Bioinformatics, metagenomics and comparative genomics are used for enzyme discovery. The target genes and proteins are characterized using methods in molecular biology, protein expression and enzymology. Both poplar and Arabidopsis are currently our plant model organisms.
The aim is to use the characterized enzymes as selective tools in biomass conversion. The research has potential to contribute to the understanding of plant fiber development and degradation, for the design of novel biomaterials, new methods for fiber modification, and for the production of biofuels.
This project is supported by the Swedish Research Council Formas and the Carl Tryggers Foundation. The research activities were initiated with funding from the Ingvar Carlsson Award from the Swedish Foundation for Strategic Research. The prestigious Ingvar Carlsson Award is a program for postdocs returning to Sweden from abroad to start their independent research career.
Present members of the group:
Dayanand Kalyani - Post-doctoral scientist, 2017-
Past members of the group:
Olov Svartström – Post-doctoral scientist, 2015-2016
Angelica Rosenholm - Laboratory engineer, 2016
Diploma thesis student, Fall semester 2015
Yang Wang – Post-graduate student 2010-2015
Erika Groth – Post-doctoral scientist, 2012-2014
Susanna Lundh - Diploma thesis student, Spring semester 2012
Chenge Li - Diploma thesis student, Spring semester 2011