Elisa Pin

My research focuses on understanding autoimmune and inflammatory diseases through comprehensive profiling of proteins and autoantibodies in patient samples. To achieve this, we use affinity-based proteomic technologies that allow us to measure large numbers of targets simultaneously from small volumes of serum or plasma. A key component of the work is the development of panels of antigens and proteins tailored to specific research questions. Through our close collaboration with the Human Protein Atlas, we are able to access broad antibody and antigen collections covering the majority of the human proteome.

Our research is embedded in a strong research network involving clinical partners in Sweden and abroad. This provides access to well-defined patient cohorts and detailed clinical datasets.

The overall goal is to uncover autoantibody and protein signatures that could support improved patient stratification and offer new insight into the biology of the disease. Much of our current work focuses on systemic autoimmune rheumatic disorders, but we also engage in collaborative studies across additional autoimmune and inflammatory conditions. Analytical efforts include hypothesis-driven evaluation of profiles and we aim to explore broader data-driven approaches to identify subgroups of patients not captured by current clinical definitions.

Affiliation:
Div of Affinity Proteomics
Dept of Protein Science
School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH)
KTH Royal Institute of Technology
SciLifeLab

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Group members:

Charlotta Preger, postdoc

Lovisa Skoglund, research engineer

Metta Berenpas, Erasmus master student, Radboud University, The Netherlands

Supervised students:

Shaghayegh Bayati, PhD student (2020-2023), KTH

Maria Aspenberg, master student, KTH (2024)

Federica Ress, Erasmus student (2022), University of Trento, Italy

Emmie Pohjanen, master student (2020), KTH

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Research funding:

• RELapses prevention in chronic autoimmune disease: common mechanisms and co-morbidities (RELENT) consortium. European Union’s Horizon 2020

•HEalth data Linkage for ClinicAL benefit (HELICAL) training network. European Union’s Horizon 2020, under the Marie Skłodowska-Curie programme

•Personalisation of Relapse Risk in Autoimmunity (PARADISE) consortium. ERAPerMed

•Hjärt-Lungfonden. "The lung fibrosis associated autoantibody repertoire in systemic sclerosis"

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Selected publications:

• Bayati S, Nazeer J, Ng J, George AM, Hayes M, Little MA, Nilsson P, Pin E. Autoantibodies towards HFE and SYT5 in anti-neutrophil cytoplasm antibody-associated vasculitis relapse. Rheumatology (Oxford). 2024 Oct 14:keae540. doi: 10.1093/rheumatology/keae540.

• Mescia F, Bayati S, Brouwer E, Heeringa P, Toonen EJM, Beenes M, Ball MJ, Rees AJ, Kain R, Lyons PA, Nilsson P, Pin E. Autoantibody Profiling and Anti-Kinesin Reactivity in ANCA-Associated Vasculitis. Int J Mol Sci. 2023 Oct 19;24(20):15341. doi: 10.3390/ijms242015341.

• Geroldinger-Simić M, Bayati S, Pohjanen E, Sepp N, Nilsson P, Pin E.  Autoantibodies against PIP4K2B and AKT3 Are Associated with Skin and Lung Fibrosis in Patients with Systemic Sclerosis. Int J Mol Sci. 2023 Mar 15;24(6):5629. doi: 10.3390/ijms24065629.

• Olofsson J, Hellström C, Andersson E, Yousef J, Skoglund L, Sjöberg R, Månberg A, Nilsson P, Pin E. Array-Based Multiplex and High-Throughput Serology Assays. Methods Mol Biol. 2023;2628:535-553. doi: 10.1007/978-1-0716-2978-9_31.

• Alkharaan H, Bayati S, Hellström C, Aleman S, Olsson A, Lindahl K, Bogdanovic G, Healy K, Tsilingaridis G, De Palma P, Hober S, Månberg A, Nilsson P, Pin E, Sällberg Chen M. Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys. J Infect Dis. 2021 Aug 2;224(3):407-414. doi: 10.1093/infdis/jiab256.