Collaborative project with CAVIDI

Quantification of low-abundant biomarkers for personilised medicine

 

A collaborative project is conducted together with CAVIDI focusing on enhancing the sensitivity of biomarker detection in body fluids, particularly in the context of muscular dystrophies such as Duchenne and Becker Muscular Dystrophy. Existing proteomics tools face challenges due to the complex nature of serum, which contains a wide range of proteins at varying concentrations. This variability often hampers the quantification of low-abundant proteins, leading to a bias toward more abundant biomarkers.

 

Schematic figure of BOLD-amplified Suspension Bead Array Sandwich Assay.

 

Master Thesis projects

2025 - Mario Alejandro Aguilar Velazquez, Optimization of a protocol for an oligonucleotide-mediated methodology to enhance the sensitivity of Duchenne Muscular Dystrophy biomarkers detection in serum samples,

2025 - Sofia Hong,Integrating Binding Oligo Ladder Detection technology with Suspension Bead Array platform for detection of low-abundant biomarkers in Duchenne Muscular Dystrophy,