Publikationer av Johan Rockberg
Refereegranskade
Artiklar
[1]
Jensen, K. T., Almeida, A. V., Rönning, S., Karlander, M., Nielsen, N. S., Thøgersen, I. B. ... Harwood, S. L. (2026). Antagonist nanobodies prevent protease inhibition by CD109. Journal of Biological Chemistry, 302(3).
[2]
Thorell, H., Rönning, S., Daoda, O., Chotteau, V., Rockberg, J. & Malm, M. (2026). Automated plasmid purification system enables increased AAV production. New Biotechnology, 93, 143-154.
[3]
Dölle, M., Hervé, M., Königsson, S., Thorwid, P., Rockberg, J. & Chotteau, V. (2026). Efficiency and scalability in harvesting mammalian cell cultures : A scale-down approach to continuous centrifugation. Journal of Biotechnology, 411, 89-101.
[4]
Laurén, I., Kostakis, A., Lord, M., Björklund, E., Wang, X., Tari, P. S. ... Mangsbo, S. (2026). Optimizing T cell responses of targeted peptide antigen delivery by modulating antigen processing through amino acid exchange. International Journal of Biological Macromolecules, 352.
[5]
Masson, H. O., Di Giusto, P., Kuo, C. C., Malm, M., Lundqvist, M., Sivertsson, Å. ... Lewis, N. E. (2025). Deciphering the determinants of recombinant protein expression across the human secretome. Proceedings of the National Academy of Sciences of the United States of America, 122(41).
[6]
Möller, M., Jönsson, M., Lundqvist, M., Rockberg, J., Löfblom, J., Tegel, H. & Hober, S. (2025). Deep sequencing combined with high-throughput screening enables efficient development of a pH-dependent high-affinity binding domain targeting HER3. Protein Science, 34(8).
[7]
Ladd, B., Tunmats, S., Gräslund, T., Daramola, O., Rockberg, J. & Chotteau, V. (2025). Heterogeneity in an adeno-associated virus transfection-based production process limits the production efficiency. Scientific Reports, 15(1).
[8]
Zhang, Y., Sundäng Peters, E., Daramola, O., Tucker, T. A., Rockberg, J., Hatton, D. & Chotteau, V. (2025). Intensification of rAAV Production Based on HEK293 Cell Transient Transfection. Biotechnology Journal, 20(6).
[9]
Mebrahtu, A., Laurén, I., Veerman, R., Akpinar, G. G., Lord, M., Kostakis, A. ... Mangsbo, S. (2024). A bispecific CD40 agonistic antibody allowing for antibody-peptide conjugate formation to enable cancer-specific peptide delivery, resulting in improved T proliferation and anti-tumor immunity in mice. Nature Communications, 15(1).
[10]
Mebrahtu, A., Aniander, G., Mega, A., Moradi, M., Thalén, N., Gudmundsdotter, L. ... Rockberg, J. (2024). Co-culture platform for tuning of cancer receptor density allows for evaluation of bispecific immune cell engagers. New Biotechnology, 79, 120-126.
[11]
Thalén, N., Karlander, M., Lundqvist, M., Persson, H., Hofström, C., Turunen, S. P. ... Rockberg, J. (2024). Mammalian cell display with automated oligo design and library assembly allows for rapid residue level conformational epitope mapping. Communications Biology, 7(1).
[12]
Thalén, N., Moradi, M., Lundqvist, M., Rodhe, J., Andersson, M., Bidkhori, G. ... Rockberg, J. (2024). Tuning of CHO secretional machinery improve activity of secreted therapeutic sulfatase 150-fold. Metabolic engineering, 81, 157-166.
[13]
Mega, A., Mebrahtu, A., Aniander, G., Ryer, E., Skold, A., Sandegren, A. ... Frejd, F. Y. (2023). A PDGFRB- and CD40-targeting bispecific AffiMab induces stroma-targeted immune cell activation. mAbs, 15(1).
[14]
Möller, M., Jönsson, M., Lundqvist, M., Hedin, B., Larsson, L., Larsson, E. ... Hober, S. (2023). An easy-to-use high-throughput selection system for the discovery of recombinant protein binders from alternative scaffold libraries. Protein Engineering Design & Selection, 36.
[15]
Moradi, M., Lundqvist, M., Harris, C., Malm, M., Volk, A.-L., Thalén, N. ... Rockberg, J. (2022). Autophagy and intracellular product degradation genes identified by systems biology analysis reduce aggregation of bispecific antibody in CHO cells. New Biotechnology, 68, 68-76.
[16]
Jönsson, M., Scheffel, J., Larsson, E., Möller, M., Rossi, G., Lundqvist, M. ... Hober, S. (2022). CaRA – A multi-purpose phage display library for selection of calcium-regulated affinity proteins. New Biotechnology, 72, 159-167.
[17]
Malm, M., Kuo, C.-C., Moradi, M., Mebrahtu, A., Wistbacka, N., Razavi, R. ... Rockberg, J. (2022). Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins. Metabolic engineering, 72, 171-187.
[18]
Saghaleyni, R., Malm, M., Moruzzi, N., Zrimec, J., Razavi, R., Wistbacka, N. ... Rockberg, J. (2022). Report Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells. Cell Reports, 39(11), 110936.
[19]
Hendrikse, N., Sandegren, A., Andersson, T., Blomqvist, J., Makower, A., Possner, D. ... Nordling, E. (2021). Ancestral lysosomal enzymes with increased activity harbor therapeutic potential for treatment of Hunter syndrome. ISCIENCE, 24(3).
[20]
Volk, A.-L., Mebrahtu, A., Ko, B. -., Lundqvist, M., Karlander, M., Lee, H. -. ... Rockberg, J. (2021). Bispecific Antibody Molecule Inhibits Tumor Cell Proliferation More Efficiently Than the Two-Molecule Combination. Drugs in R&D, 21(2), 157-168.
[21]
Ding, M., Malhotra, R., Ottosson, T., Lundqvist, M., Mebrahtu, A., Brengdahl, J. ... Holmberg Schiavone, L. (2021). Secretome screening reveals immunomodulating functions of IFNα-7, PAP and GDF-7 on regulatory T-cells. Scientific Reports, 11(1).
[22]
von Witting, E., Lindbo, S., Lundqvist, M., Möller, M., Wisniewski, A., Kanje, S. ... Hober, S. (2021). Small Bispecific Affinity Proteins for Simultaneous Target Binding and Albumin-Associated Half-Life Extension. Molecular Pharmaceutics, 18(1), 328-337.
[23]
Malm, M., Saghaleyni, R., Lundqvist, M., Giudici, M., Chotteau, V., Field, R. ... Rockberg, J. (2020). Evolution from adherent to suspension : systems biology of HEK293 cell line development. Scientific Reports, 10(1).
[24]
Tegel, H., Dannemeyer, M., Kanje, S., Sivertsson, Å., Berling, A., Svensson, A.-S. ... Hober, S. (2020). High throughput generation of a resource of the human secretome in mammalian cells. New Biotechnology, 58, 45-54.
[25]
Zhan, C., Bidkhori, G., Schwarz, H., Malm, M., Mebrahtu, A., Field, R. ... Chotteau, V. (2020). Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells. iScience, 23(11).
[26]
Nasi, A., McArdle, S., Gaudernack, G., Westman, G., Melief, C., Rockberg, J. ... Mangsbo, S. (2020). Reactive oxygen species as an initiator of toxic innate immune responses in retort to SARS-CoV-2 in an ageing population, consider N-acetylcysteine as early therapeutic intervention. Toxicology reports, 7, 768-771.
[27]
Schwarz, H., Zhang, Y., Zhan, C., Malm, M., Field, R., Turner, R. ... Chotteau, V. (2020). Small-scale bioreactor supports high density HEK293 cell perfusion culture for the production of recombinant Erythropoietin. Journal of Biotechnology, 309, 44-52.
[28]
Eisenhut, P., Mebrahtu, A., Moradi Barzadd, M., Thalén, N., Klanert, G., Weinguny, M. ... Rockberg, J. (2020). Systematic use of synthetic 5'-UTR RNA structures to tune protein translation improves yield and quality of complex proteins in mammalian cell factories. Nucleic Acids Research, 48(20).
[29]
Lundqvist, M., Thalén, N., Volk, A.-L., Hansen, H. G., von Otter, E., Nygren, P.-Å. ... Rockberg, J. (2019). Chromophore pre-maturation for improved speed and sensitivity of split-GFP monitoring of protein secretion. Scientific Reports, 9.
[30]
Hu, F. J., Lundqvist, M., Uhlén, M. & Rockberg, J. (2019). SAMURAI (Solid-phase Assisted Mutagenesis by Uracil Restriction for Accurate Integration) for antibody affinity maturation and paratope mapping. Nucleic Acids Research, 47(6).
[31]
Häussler, R. S., Bendes, A., Iglesias, M. J., Sanchez-Rivera, L., Dodig-Crnkovic, T., Byström, S. ... Schwenk, J. M. (2019). Systematic Development of Sandwich Immunoassays for the Plasma Secretome. Proteomics.
[32]
Uhlén, M., Karlsson, M. J., Hober, A., Svensson, A.-S., Scheffel, J., Kotol, D. ... Sivertsson, Å. (2019). The human secretome. Science Signaling, 12(609).
[33]
Nilvebrant, J. & Rockberg, J. (2018). An introduction to epitope mapping. Methods in Molecular Biology, 1785, 1-10.
[34]
Hu, F. J., Volk, A.-L., Persson, H., Säll, A., Borrebaeck, C., Uhlén, M. & Rockberg, J. (2018). Combination of phage and Gram-positive bacterial display of human antibody repertoires enables isolation of functional high affinity binders. New Biotechnology, 45, 80-88.
[35]
Zamani, L., Lundqvist, M., Zhang, Y., Aberg, M., Edfors, F., Bidkhori, G. ... Chotteau, V. (2018). High Cell Density Perfusion Culture has a Maintained Exoproteome and Metabolome. Biotechnology Journal, 13(10).
[36]
Thul, P. J., Åkesson, L., Wiking, M., Mahdessian, D., Geladaki, A., Ait Blal, H. ... Lundberg, E. (2017). A subcellular map of the human proteome. Science, 356(6340).
[37]
Sastry, A., Monk, J., Tegel, H., Uhlén, M., Pålsson, B. O., Rockberg, J. & Brunk, E. (2017). Machine learning in computational biology to accelerate high-throughput protein expression. Bioinformatics, 33(16), 2487-2495.
[38]
Volk, A.-L., Hu, F. J., Berglund, M. M., Nordling, E., Strömberg, P., Uhlén, M. & Rockberg, J. (2016). Stratification of responders towards eculizumab using a structural epitope mapping strategy. Scientific Reports, 6.
[39]
Ko, B.-K., Lee, S.-Y., Lee, Y.-H., Hwang, I.-S., Persson, H., Rockberg, J. ... Lee, J.-S. (2015). Combination of novel HER2-targeting antibody 1E11 with trastuzumab shows synergistic antitumor activity in HER2-positive gastric cancer. Molecular Oncology, 9(2), 398-408.
[40]
Forsström, B., Axnäs, B. B., Rockberg, J., Danielsson, H., Bohlin, A. & Uhlén, M. (2015). Dissecting Antibodies with Regards to Linear and Conformational Epitopes. PLOS ONE, 10(3).
[41]
Anfelt, J., Kaczmarzyk, D., Shabestary, K., Renberg, B., Rockberg, J., Nielsen, J. ... Hudson, E. P. (2015). Genetic and nutrient modulation of acetyl-CoA levels in Synechocystis for n-butanol production. Microbial Cell Factories, 14.
[42]
Lundqvist, M., Edfors, F., Sivertsson, Å., Hallström, B. M., Hudson, E. P., Tegel, H. ... Rockberg, J. (2015). Solid-phase cloning for high-throughput assembly of single and multiple DNA parts. Nucleic Acids Research, 43(7).
[43]
Uhlén, M., Fagerberg, L., Hallström, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A. ... Pontén, F. (2015). Tissue-based map of the human proteome. Science, 347(6220), 1260419.
[44]
Hansen, H. G., Nilsson, C. N., Lund, A. M., Kol, S., Grav, L. M., Lundqvist, M. ... Kildegaard, H. F. (2015). Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells. Scientific Reports, 5.
[45]
Hu, F. J., Uhlén, M. & Rockberg, J. (2014). Generation of HER2 monoclonal antibodies using epitopes of a rabbit polyclonal antibody. New Biotechnology, 31(1), 35-43.
[46]
Forsström, B., Axnäs, B. B., Stengele, K.-P., Buehler, J., Albert, T. J., Richmond, T. A. ... Uhlén, M. (2014). Proteome-wide Epitope Mapping of Antibodies Using Ultra-dense Peptide Arrays. Molecular & Cellular Proteomics, 13(6), 1585-1597.
[47]
Hudson, E. P., Nikoshkov, A., Uhlén, M. & Rockberg, J. (2012). Automated Solid-Phase Subcloning Based on Beads Brought into Proximity by Magnetic Force. PLOS ONE, 7(5), e37429.
[48]
Buus, S., Rockberg, J., Forsström, B., Nilsson, P., Uhlén, M. & Schafer-Nielsen, C. (2012). High-resolution mapping of linear antibody epitopes using ultrahigh-density peptide microarrays. Molecular & Cellular Proteomics, 11(12), 1790-1800.
[49]
Hudson, E. P., Uhlén, M. & Rockberg, J. (2012). Multiplex epitope mapping using bacterial surface display reveals both linear and conformational epitopes. Scientific Reports, 2, 706.
[50]
Hjelm, B., Forsström, B., Löfblom, J., Rockberg, J. & Uhlén, M. (2012). Parallel Immunizations of Rabbits Using the Same Antigen Yield Antibodies with Similar, but Not Identical, Epitopes. PLOS ONE, 7(12), e45817.
[51]
Hjelm, B., Forsström, B., Igel, U., Johannesson, H., Stadler, C., Lundberg, E. ... Uhlen, M. (2011). Generation of monospecific antibodies based on affinity capture of polyclonal antibodies. Protein Science, 20(11), 1824-1835.
[52]
Rockberg, J., Löfblom, J., Hjelm, B., Ståhl, S. & Uhlén, M. (2010). Epitope mapping using gram-positive surface display. Current Protocols in Immunology(SUPPL. 90), 9.9.1-9.9.17.
[53]
Hjelm, B., Fernandez, C. D., Löfblom, J., Ståhl, S., Johannesson, H., Rockberg, J. & Uhlen, M. (2010). Exploring epitopes of antibodies toward the human tryptophanyl-tRNA synthetase. NEW BIOTECHNOL, 27(2), 129-137.
[54]
Kronqvist, N., Malm, M., Rockberg, J., Hjelm, B., Uhlén, M., Ståhl, S. & Löfblom, J. (2010). Staphylococcal surface display in combinatorial protein engineering and epitope mapping of antibodies. Recent Patents on Biotechnology, 4(3), 171-182.
[55]
Rockberg, J., Schwenk, J. M. & Uhlén, M. (2009). Discovery of epitopes for targeting the human epidermal growth factor receptor 2 (HER2) with antibodies. Molecular Oncology, 3(3), 238-247.
[56]
Kronqvist, N., Rockberg, J., Hjelm, B., Ståhl, S., Uhlén, M. & Löfblom, J. (2009). New Ways for Discovery of Biopharmaceuticals : Emerging Techniques using Surface Display on Gram-positive Bacteria for Combinatorial Protein Engineering and Characterization. Bioforum Europe, 13(6-7), 022.
[57]
Rockberg, J. & Uhlén, M. (2009). Prediction of antibody response using recombinant human protein fragments as antigen. Protein Science, 18(11), 2346-2355.
[58]
Berglund, L., Björling, E., Jonasson, K., Rockberg, J., Fagerberg, L., Al-Khalili Szigyarto, C. ... Uhlén, M. (2008). A whole-genome bioinformatics approach to selection of antigens for systematic antibody generation. Proteomics, 8(14), 2832-2839.
[59]
Rockberg, J., Löfblom, J., Hjelm, B., Ståhl, S. & Uhlén, M. (2008). Epitope mapping of antibodies using bacterial surface display. Nature Methods, 5(12), 1039-1045.
[60]
Uhlén, M., Björling, E., Agaton, C., Al-Khalili Szigyarto, C., Amini, B., Andersen, E. ... Pontén, F. (2005). A human protein atlas for normal and cancer tissues based on antibody proteomics. Molecular & Cellular Proteomics, 4(12), 1920-1932.
[61]
Lindskog, M., Rockberg, J., Uhlén, M. & Sterky, F. (2005). Selection of protein epitopes for antibody production. BioTechniques, 38(5), 723-727.
Kapitel i böcker
[62]
Nilvebrant, J., Thalén, N. B., Rockberg, J. & Malm, M. (2025). An Overview of Epitopes and Methods for Antibody Epitope Mapping. I Methods in Molecular Biology (s. 1-11). Springer Nature.
[63]
Volk, A.-L., Hu, F. J., Malm, M. & Rockberg, J. (2025). Epitope Mapping of Antibodies Using Bacterial Cell Surface Display of Gene Fragment Libraries. I Methods in Molecular Biology (s. 147-162). Springer Nature.
[64]
Thalén, N., Karlander, M., Malm, M. & Rockberg, J. (2025). Mammalian Cell Display with Automated Oligo Design and Library Assembly Allows for Rapid Residue Level Conformational Epitope Mapping. I Methods in Molecular Biology (s. 133-146). Springer Nature.
[65]
Volk, A.-L. & Rockberg, J. (2025). Mapping of Antibody Structural Epitopes Using Bacterial Cell Surface Display of Folded Domains. I Methods in Molecular Biology (s. 163-187). Springer Nature.
[66]
Volk, A.-L. & Rockberg, J. (2018). Discontinuous epitope mapping of antibodies using bacterial cell surface display of folded domains. I Epitope Mapping Protocols (s. 159-183). Humana Press.
[67]
Volk, A.-L., Hu, F. J. & Rockberg, J. (2018). Epitope mapping of antibodies using bacterial cell surface display of gene fragment libraries. I Epitope Mapping Protocols (s. 141-157). Humana Press.
[68]
Volk, A. L., Hu, F. J. & Rockberg, J. (2014). Epitope mapping of monoclonal and polyclonal antibodies using bacterial cell surface display. I Monoclonal antibodies (s. 485-500). Humana Press.
Icke refereegranskade
Artiklar
[69]
Rönning, S., Thorell, H., Malm, M. & Rockberg, J. (2025). Automated plasmid purification can reducemanual labour and increase titres in AAV production. Human Gene Therapy, 36(3-4), E179-E180.
[70]
Thorell, H., Karlander, M., Thalén, N., Fresk, M., Villacañas González, M. D. C., Jung, T. ... Rockberg, J. (2025). Selective DNA delivery through amodular AAV platform utilising Affibody binding domains. Human Gene Therapy, 36(3-4), E211-E212.
[71]
Esnal, M. R., Arrías, P. N., Rockberg, J. & Malm, M. (2025). Understanding recombinant AAV production kinetics in HEK293 cells. Human Gene Therapy, 36(3-4), E189-E189.
[72]
Malm, M., Volk, A.-L., Karlander, M., Lundqvist, M., Wistbacka, N., Razavi, R. ... Rockberg, J. (2021). Improving targeting and yield of AAV by capsid and cell engineering. Human Gene Therapy, 32(19-20), A119-A120.
[73]
Rockberg, J. (2016). Split-GFP and droplet microfluidics allows high-throughput screening of mammalian cell factories. New Biotechnology, 33, S51-S51.
[74]
Rockberg, J., Szigyarto, C. A. & Uhlén, M. (2004). Antigen selection for design of protein epitope signature tags. Molecular & Cellular Proteomics, 3(10), S5-S5.
[75]
Szigyarto, C. A., Berglund, L., Sivertsson, Å., Lindskog, M., Rockberg, J., Westberg, J. ... Uhlén, M. (2004). Statistics of protein epitope signature tag design within the Swedish human proteom resource. Molecular & Cellular Proteomics, 3(10), S91-S91.
[76]
Sterky, F., Berglund, L., Lindskog, M., Rockberg, J., Al-Khalili Szigyarto, C. & Uhlén, M. (2004). Strategies and software for design of protein Epitopes within HPR. Molecular & Cellular Proteomics, 3(10), S4-S4.
Konferensbidrag
[77]
Rockberg, J., Nilvebrant, J. (2018). Preface. I Methods in Molecular Biology: -. (s. v-vi). Humana Press.
Kapitel i böcker
[78]
Rockberg, J., Nilvebrant, J., Malm, M. & Thalén, N. (2025). Preface. I Methods in Molecular Biology (s. v-vi). Humana Press Inc.
Avhandlingar
[79]
Rockberg, J. (2008). Methods for Generation and Characterization of Monospecific Antibodies (Doktorsavhandling , KTH, Stockholm, Trita-BIO-Report 2008:20). Hämtad från http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-9338.
Samlingsverk (redaktörskap)
[80]
Rockberg, J., Nilvebrant, J., Malm, M., Thalén, N. (Red.). (2025). Epitope Mapping Protocols. Springer Nature.
Övriga
[81]
Mega, A., Mebrahtu, A., Aniander, G., Ryer, E., Sköld, A., Sandegren, A., Backström Rydin, E., Rockberg, J., Östman, A., Y. Frejd, F. (). A PDGFRB and CD40 targeting bispecific AffiMab induces stroma targeted immune cell activation. (Manuskript).
[82]
Thorell, H., Karlander, M., Thalén, N., Ryner, M., Fresk, M., Villacañas González, M. D. C., Jung, T., Douthwaite, J., Cusdin, F., Hatton, D., Malm, M., Rockberg, J. (). A modular binding domain AAV platform for cell surface receptor-selective DNA delivery. (Manuskript).
[83]
Thorell, H., Karlander, M., Rönning, S., Berndt Thalén, N., Ryner, M., Jung, T., Leroy, P., Liu, J., Metzendorf, N. G., Fresk, M., Bååth, E., Villacañas González, M. D. C., Vistbacka, N., Binny, C., Hultqvist, G., Hatton, D., Malm, M., Rockberg, J. (). A whole body-scale Affibody-based platform for cell-selective in vivo gene therapy. (Manuskript).
[84]
von Witting, E., Lindbo, S., Lundqvist, M., Möller, M., Wisniewski, A., Kanje, S., Rockberg, J., Tegel, H., Åstrand, M., Uhlén, M., Hober, S. (). ADAPT as a single-domain bispecific scaffold capable of albumin-associated haf-life extension for therapeutic applications. (Manuskript).
[85]
Karlander, M., Karlsson, A., Ryner, M., Jung, T., Bausewein, T., Coulomb-Delsuc, M., Wistbacka, N., Grassi, L., Cusdin, F., Douthwaite, J., Hatton, D., Malm, M., Rockberg, J. (). Amplification and Fragmentation Free Long-read Sequencing Enables Rapid Analysis of Packaged Adeno-associated Virus ssDNA. (Manuskript).
[86]
Mebrahtu, A., Lauren, I., Veerman, R. E., Güclüler Akpinar, G., Lord, M., Kostakis, A., Astorga-Wells, J., Dahllund, L., Olsson, A., Persson, J., Persson, H., Pierre, D., Rockberg, J., Mangsbo, S. (). An Adaptable Drug Affinity Conjugate targeting CD40 for modular non-covalent delivery of neoantigens providing robust T-cell activation and increased overall survival in tumor-bearing mice. (Manuskript).
[87]
Moradi, M., Lundqvist, M., Harris, C., Malm, M., Volk, A.-L., Thalén, N., Chotteau, V., Grassi, L., Smith, A., Abadi, M. L., Lambiase, G., Gibson, S., Hatton, D., Rockberg, J. (). Autophagy and intracellular product degradation genes reduce aggregation of bispecific antibody in CHO cells with a high translational burden. (Manuskript).
[88]
Jonsson, M., Scheffel, J., Larsson, E., Möller, M., Rossi, G., Lundqvist, M., Rockberg, J., Uhlén, M., Tegel, H., Kanje, S., Hober, S. (). CaRA – A Multi-Purpose Phage Display Library for Selection of Calcium-Regulated Affinity Proteins. (Manuskript).
[89]
Thorell, H., Karlander, M., Wistbacka, N., Volk, A.-L., Fresk, M., Pintar, A., Villacañas González, M. D. C., Jung, T., Binny, C., Hatton, D., Malm, M., Rockberg, J. (). Comparison of AAV1-9 production in adherent and suspension HEK293 cells suggests capsid engineering for improved AAV titres. (Manuskript).
[90]
Möller, M., Jönsson, M., Lundqvist, M., Rockberg, J., Löfblom, J., Tegel, H., Hober, S. (). Deep sequencing combined with high-throughput screening enables efficient development of a pH-dependent high affinity binder targeting HER3. (Manuskript).
[91]
Mebrahtu, A., Svensson Gelius, S., Su, C., M. Berglund, M., Strömberg, P., Cornevik, T., Elorant, M.-L., Rönnblom, L., Parodis, I., Brodin, P., Y. Frejd, F., Rockberg, J. (). Disrupting the hyperactive inflammatory cycle in SLE - A bispecific drug targeting C5 and IFNa in the Complement and Innate immune system. (Manuskript).
[92]
Aniander, G., Mirazadeh, K., Thalén, N., Volk, A.-L., Samuelson, P., Rockberg, J. (). Enhanced titer and quality of IgGs through alterations at the translation initiation sequence. (Manuskript).
[93]
Malm, M., Kuo, C.-C., Moradi Barzadd, M., Mebrahtu, A., Wistbacka, N., Razavi, R., Volk, A.-L., Lundqvist, M., Kotol, D., Edfors, F., Gräslund, T., Chotteau, V., Field, R., Varley, P. G., Roth, R. G., Lewis, N. E., Hatton, D., Rockberg, J. (). Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins. (Manuskript).
[94]
Zhan, C., Hubert, S., Malm, M., Sellick, C., Rockberg, J., Chotteau, V. (). Hydrodynamic shear stress in hollow filter for perfusion culture of human cells. (Manuskript).
[95]
Thalén, N., Lundqvist, M., Persson, H., Hofström, C., Turunen, P., Godzwon, M., Volk, A.-L., Ohlin, M., Rockberg, J. (). Mammalian cell surface display system for conformational epitope determination of SARS-CoV-2 neutralizing antibodies. (Manuskript).
[96]
Wisniewski, A., Larsson, L., Lundqvist, M., Rockberg, J., Tegel, H., Uhlén, M., Hober, S. (). Single domain ADAPT able to target Interleukin-17c with high affinity and albumin simultaneously for potential half-life extension. (Manuskript).
[97]
Schwarz, H., Zhang, Y., Zhan, C., Malm, M., Field, R., Turner, R., Sellick, C., Varley, P., Rockberg, J., Chotteau, V. (). Small-scale bioreactor supports high density HEK293 cell perfusion culture for the production of recombinant Erythropoietin. (Manuskript).
[98]
Thorell, H., Malm, M., Mim, C., Rockberg, J. (). Structural localisation of a folded affinity protein displayed on the adeno-associated virus 2 capsid. (Manuskript).
[99]
Karlander, M., Rönning, S., Lundqvist, M., Malm, M., Rockberg, J. (). Survival of the less fit - directed evolution via deep sequencing enables selection of diverse high affinity proteins. (Manuskript).
[100]
Thalén, N., Moradi, M., Lundqvist, M., Rodhe, J., Andersson, M., Bidkori, G., Possner, D., Su, C., Nilsson, J., Eisenhut, P., Malm, M., Westin, J., Forsberg, J., Nordling, E., Mardinoglu, A., Volk, A.-L., Sandegren, A., Rockberg, J. (). Systems biology greatly improve activity of secreted therapeutic sulfatase in CHO bioprocess. (Manuskript).
[101]
Mebrahtu, A., Aniander, G., Mega, A., Moradi, M., Thalén, N., Gudmundsdotter, L., Backström Rydin, E., Sandegren, A., Frejd, F. Y., Rockberg, J. (). Tuning of PDGFRB density on cell surface allows for selective B cell activation with CD40-targeting bi-specific antibody. (Manuskript).
[102]
Thalén, N., Hicks, J., Lundqvist, M., Backmark, A., Engberg, S., Raynoschek, C., Gunnarsson, J., Volk, A.-L., Roth, R., Rockberg, J. (). ULK1 knockout cell line downregulates autophagy, upregulates recombinant transcript and improves protein secretion. (Manuskript).
Senaste synkning med DiVA:
2026-09-05 22:27:56 UTC