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Postdoc (scholarship) in computational biophysics

KTH Royal Institute of Technology in Stockholm has grown to become one of Europe’s leading technical and engineering universities, as well as a key centre of intellectual talent and innovation. We are Sweden’s largest technical research and learning institution and home to students, researchers and faculty from around the world. Our research and education covers a wide area including natural sciences and all branches of engineering, as well as architecture, industrial management, urban planning, history and philosophy.

The workplace

www.biophysics.se/

Project description

Membrane proteins such as GPCRs and ion channels are important drug targets. Rational drug design for these proteins, however, has proved challenging because of off-target binding. Pore blockers, for example, tend to bind hydrophobic regions indiscriminately, leading to side effects that in the worst case have led drugs to be withdrawn from the market.

Regions of the proteins with lower conservation could be targeted to avoid hitting related proteins. However, those are often found in membrane facing regions and existing drug screening methods are not suited to take into account the competition with the complex and heterogeneous lipidic environment.

In this project, we propose to develop methodologies to develop such modulators. This project is part of a longer term project aiming to to design of new modulation strategies, which are much needed for the treatment of drug-resistant excitability disorders such as epilepsies, Parkinson’s disease or long QT syndrome.

Qualifications

Requirements: A doctoral degree or an equivalent foreign degree, obtained within the last three years prior to the application deadline.

The successful candidate is expected to have a PhD in physics, chemistry, applied maths or computer science.

Applicants must be strongly motivated to learn and develop new skills, possess the ability to work independently and perform critical analysis. Applicants will also have a demonstrated ability to work in teams and to communicate research in a written and oral form. Note that a good command of English is essential, both as the local working language and because of our international collaborations.

Application

Apply to this scholarship by e-mail to scholarshipapplication@sci.kth.se . You are the main responsible to ensure that your application is complete according to the ad. Your complete application must be received at KTH no later than 2021-04-28. Mark your application with reference number S-2021-0475.

The application must include the following documents:

  • Curriculum vitae
  • Cover letter (detailing both your previous scientific work experience and your interest in this position)
  • Contact information for two references

Please observe that you apply for a scholarship, not an employment.

About the position/positions

Period: 24 months

Extent: Full-time

Number of positions: 1

Amount of scholarship: 27000 kr

Location: SciLifeLab Stockholm

Contact

Lucie Delemotte ( Lucie.delemotte@scilifelab.se )

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