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Publications by Per-Olof Syrén

Peer reviewed


B. A. Nebel et al., "A Career in Catalysis : Bernhard Hauer," ACS Catalysis, vol. 13, no. 13, pp. 8861-8889, 2023.
D. A. Hueting et al., "Design, structure and plasma binding of ancestral β-CoV scaffold antigens," Nature Communications, vol. 14, no. 1, 2023.
S. Subramaniyan et al., "Designed for Circularity : Chemically Recyclable and Enzymatically Degradable Biorenewable Schiff Base Polyester-Imines," ACS Sustainable Chemistry and Engineering, vol. 11, no. 8, pp. 3451-3465, 2023.
B. Guo et al., "Conformational Selection in Biocatalytic Plastic Degradation by PETase," ACS Catalysis, vol. 12, no. 6, pp. 3397-3409, 2022.
D. A. Hueting, S. R. Vanga and P.-O. Syrén, "Thermoadaptation in an Ancestral Diterpene Cyclase by Altered Loop Stability," Journal of Physical Chemistry B, vol. 126, no. 21, pp. 3809-3821, 2022.
C. Jönsson et al., "Biocatalysis in the Recycling Landscape for Synthetic Polymers and Plastics towards Circular Textiles," ChemSusChem, vol. 14, no. 19, pp. 4028-4040, 2021.
K. Schriever et al., "Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase," Journal of the American Chemical Society, vol. 143, no. 10, pp. 3794-3807, 2021.
A. Stamm et al., "Pinene-Based Oxidative Synthetic Toolbox for Scalable Polyester Synthesis," JACS Au, vol. 1, no. 11, pp. 1949-1960, 2021.
W. Farhat et al., "Lactone monomers obtained by enzyme catalysis and their use in reversible thermoresponsive networks," Journal of Applied Polymer Science, vol. 137, no. 18, 2020.
A. Stamm et al., "A retrobiosynthesis-based route to generate pinene-derived polyesters," ChemBioChem, vol. 20, pp. 1664-1671, 2019.
W. Farhat et al., "Biocatalysis for terpene-based polymers," Zeitschrift für Naturforschung C - A Journal of Biosciences, vol. 74, no. 3-4, pp. 90-99, 2019.
A. Stamm et al., "Chemo- enzymatic pathways toward pinene- based renewable materials," Green Chemistry, vol. 21, no. 10, pp. 2720-2731, 2019.
A. Biundo et al., "Switched reaction specificity in polyesterases towards amide bond hydrolysis by enzyme engineering," RSC Advances, vol. 9, no. 62, pp. 36217-36226, 2019.
N. Hendrikse et al., "Ancestral diterpene cyclases show increased thermostability and substrate acceptance," The FEBS Journal, vol. 285, no. 24, pp. 4660-4673, 2018.
P.-O. Syrén, "Enzymatic Hydrolysis of Tertiary Amide Bonds by anti Nucleophilic Attack and Protonation," Journal of Organic Chemistry, vol. 83, no. 21, pp. 13543-13548, 2018.
A. Eriksson, C. Kürten and P.-O. Syrén, "Protonation-Initiated Cyclization by a ClassII Terpene Cyclase Assisted by Tunneling," ChemBioChem, vol. 18, no. 23, pp. 2301-2305, 2017.
N. M. Hendrikse et al., "Redesign of biosynthetic enzymes using ancestral sequence reconstruction," The FEBS Journal, vol. 284, pp. 86-87, 2017.
M. J. Fink and P.-O. Syrén, "Redesign of water networks for efficient biocatalysis," Current opinion in chemical biology, vol. 37, pp. 107-114, 2017.
J. Fagerland et al., "Template-assisted enzymatic synthesis of oligopeptides from a polylactide chain," Biomacromolecules, vol. 18, no. 12, pp. 4271-4280, 2017.
C. Kürten, B. Carlberg and P.-O. Syren, "Mechanism-Guided Discovery of an Esterase Scaffold with Promiscuous Amidase Activity," Catalysts, vol. 6, no. 6, 2016.
P.-O. Syrén et al., "Squalene-hopene cyclases : evolution, dynamics and catalytic scope," Current opinion in structural biology, vol. 41, pp. 73-82, 2016.
C. Kürten and P.-O. Syren, "Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes," Journal of Visualized Experiments, no. 107, 2016.
P. Hendil-Forssell, M. Martinelle and P.-O. Syren, "Exploring water as building bricks in enzyme engineering," Chemical Communications, vol. 51, no. 97, pp. 17221-17224, 2015.
C. Kürten, M. Uhlén and P.-O. Syrén, "Overexpression of functional human oxidosqualene cyclase in Escherichia coli," Protein Expression and Purification, vol. 115, pp. 46-53, 2015.
P.-O. Syrén et al., "Entropy is Key to the Formation of Pentacyclic Terpenoids by Enzyme-Catalyzed Polycyclization," Angewandte Chemie International Edition, vol. 53, no. 19, pp. 4845-4849, 2014.
P.-O. Syrén et al., "Proton Shuttle Mechanism in the Transition State of Lipase-Catalyzed N-Acylation of Amino Alcohols," ChemCatChem, vol. 5, no. 7, pp. 1842-1853, 2013.
S. C. Hammer et al., "Squalene hopene cyclases : highly promiscuous and evolvable catalysts for stereoselective CC and CX bond formation," Current opinion in chemical biology, vol. 17, no. 2, pp. 293-300, 2013.
M. Seitz et al., "Synthesis of Heterocyclic Terpenoids by Promiscuous Squalene-Hopene Cyclases," ChemBioChem, vol. 14, no. Copyright (C) 2013 American Chemical Society (ACS). All Rights Reserved., pp. 436-439, 2013.
P.-O. Syren, "The solution of nitrogen inversion in amidases," The FEBS Journal, vol. 280, no. 13, pp. 3069-3083, 2013.
S. C. Hammer et al., "Stereoselective Friedel-Crafts alkylation catalyzed by squalene hopene cyclases," Tetrahedron, vol. 68, no. Copyright (C) 2013 American Chemical Society (ACS). All Rights Reserved., pp. 7624-7629, 2012.
P.-O. Syrén and K. Hult, "Amidases have a hydrogen bond that facilitates nitrogen inversion but esterases have not," ChemCatChem, vol. 3, no. 5, pp. 853-860, 2011.
K. Engström et al., "Mutated variant of Candida antarctica lipase B in (S)-selective dynamic kinetic resolution of secondary alcohols," Organic and biomolecular chemistry, vol. 9, no. 1, pp. 81-82, 2011.
P.-O. Syren et al., "Increased activity of enzymatic transacylation of acrylates through rational design of lipases," Journal of Molecular Catalysis B : Enzymatic, vol. 65, no. 1-4, pp. 3-10, 2010.
P.-O. Syrén and K. Hult, "Substrate Conformations Set the Rate of Enzymatic Acrylation by Lipases," ChemBioChem, vol. 11, no. 6, pp. 802-810, 2010.

Chapters in books

I. V. Pavlidis, N. Hendrikse and P.-O. Syrén, "Computational Techniques for Efficient Biocatalysis," in Modern Biocatalysis : Advances Towards Synthetic Biological Systems, Gavin Williams, Mélanie Hall Ed., : Royal Society of Chemistry, 2018, pp. 119-152.
P.-O. Syrén, "Understanding esterase and amidase reaction specificities by molecular modelling," in Understanding enzymes; Function, Design, Engineering and Analysis, : Pan Standford Publishing, 2016, p. 523.

Non-peer reviewed


W. Farhat et al., "Enzymatic route for the synthesis of norcamphor lactone and its polymerization for applications as thermo-sensitive networks," Abstracts of Papers of the American Chemical Society, vol. 258, 2019.
L. Fogelström et al., "New chemo-enzymatic pathways for sustainable terpene-based polymeric materials," Abstracts of Papers of the American Chemical Society, vol. 257, 2019.
E. Malmström et al., "Sustainable terpene-based polymeric materials," Abstracts of Papers of the American Chemical Society, vol. 257, 2019.
A. Biundo et al., "Increasing amide acceptance on a polyester-hydrolyzing enzyme," New Biotechnology, vol. 33, pp. S105-S105, 2016.
P.-O. Syrén and K. Hult, "Least-motion mechanism in enzyme catalysis," The FEBS Journal, vol. 277, pp. 263-263, 2010.

Chapters in books

P.-O. Syrén, "Understanding esterase and amidase reaction specificities by molecular modeling," in Understanding Enzymes: Function, Design, Engineering and Analysis, : Pan Stanford Publishing, 2016, pp. 523-558.


P.-O. Syrén, "On electrostatic effects, minimal motion and other catalytic strategies used by enzymes," Doctoral thesis Stockholm : KTH Royal Institute of Technology, Trita-BIO-Report, 14, 2011.


X. Lopez-Lorenzo, R. Ganapathy and P.-O. Syrén, "Conformational Selection in Enzyme-Catalyzed Depolymerization of Bio-based Polyesters," (Manuscript).
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2024-07-17 11:12:31