Publications by Per-Olof Syrén
Peer reviewed
Articles
[1]
S. Subramaniyan et al., "Designing from biobased to closed-loop circularity: Flexible dynamic polyimine-amide networks," Chemical Engineering Journal, vol. 501, 2024.
[2]
B. A. Nebel et al., "A Career in Catalysis : Bernhard Hauer," ACS Catalysis, vol. 13, no. 13, pp. 8861-8889, 2023.
[3]
D. A. Hueting et al., "Design, structure and plasma binding of ancestral β-CoV scaffold antigens," Nature Communications, vol. 14, no. 1, 2023.
[4]
S. Subramaniyan et al., "Designed for Circularity : Chemically Recyclable and Enzymatically Degradable Biorenewable Schiff Base Polyester-Imines," ACS Sustainable Chemistry and Engineering, vol. 11, no. 8, pp. 3451-3465, 2023.
[5]
B. Guo et al., "Fast Depolymerization of PET Bottle Mediated by Microwave Pre-Treatment and An Engineered PETase," ChemSusChem, vol. 16, no. 18, 2023.
[6]
E. Sporre et al., "Metabolite interactions in the bacterial Calvin cycle and implications for flux regulation," Communications Biology, vol. 6, no. 1, 2023.
[7]
A. Biundo et al., "Regio- and stereoselective biocatalytic hydration of fatty acids from waste cooking oils en route to hydroxy fatty acids and bio-based polyesters," Enzyme and microbial technology, vol. 163, 2023.
[8]
X. Lopez-Lorenzo et al., "Whole-cell Mediated Carboxylation of 2-Furoic Acid Towards the Production of Renewable Platform Chemicals and Biomaterials," ChemCatChem, vol. 15, no. 6, 2023.
[9]
B. Guo et al., "Conformational Selection in Biocatalytic Plastic Degradation by PETase," ACS Catalysis, vol. 12, no. 6, pp. 3397-3409, 2022.
[10]
D. A. Hueting, S. R. Vanga and P.-O. Syrén, "Thermoadaptation in an Ancestral Diterpene Cyclase by Altered Loop Stability," Journal of Physical Chemistry B, vol. 126, no. 21, pp. 3809-3821, 2022.
[11]
N. Hendrikse et al., "Ancestral lysosomal enzymes with increased activity harbor therapeutic potential for treatment of Hunter syndrome," ISCIENCE, vol. 24, no. 3, 2021.
[12]
A. Hunold et al., "Assembly of a Rieske non-heme iron oxygenase multicomponent system from Phenylobacterium immobile E DSM 1986 enables pyrazon cis-dihydroxylation in E. coli," Applied Microbiology and Biotechnology, vol. 105, no. 5, pp. 2003-2015, 2021.
[13]
C. Jönsson et al., "Biocatalysis in the Recycling Landscape for Synthetic Polymers and Plastics towards Circular Textiles," ChemSusChem, vol. 14, no. 19, pp. 4028-4040, 2021.
[14]
K. Schriever et al., "Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase," Journal of the American Chemical Society, vol. 143, no. 10, pp. 3794-3807, 2021.
[15]
A. E. Alexakis et al., "Modification of cellulose through physisorption of cationic bio-based nanolatexes - comparing emulsion polymerization and RAFT-mediated polymerization-induced self-assembly," Green Chemistry, vol. 23, no. 5, pp. 2113-2122, 2021.
[16]
A. Stamm et al., "Pinene-Based Oxidative Synthetic Toolbox for Scalable Polyester Synthesis," JACS Au, vol. 1, no. 11, pp. 1949-1960, 2021.
[17]
S. Zokaei et al., "Toughening of a Soft Polar Polythiophene through Copolymerization with Hard Urethane Segments," Advanced Science, vol. 8, no. 2, 2021.
[18]
N. M. Hendrikse et al., "Exploring the therapeutic potential of modern and ancestral phenylalanine/tyrosine ammonia-lyases as supplementary treatment of hereditary tyrosinemia," Scientific Reports, vol. 10, no. 1, 2020.
[19]
W. Farhat et al., "Lactone monomers obtained by enzyme catalysis and their use in reversible thermoresponsive networks," Journal of Applied Polymer Science, vol. 137, no. 18, 2020.
[20]
A. Stamm et al., "A retrobiosynthesis-based route to generate pinene-derived polyesters," ChemBioChem, vol. 20, pp. 1664-1671, 2019.
[21]
W. Farhat et al., "Biocatalysis for terpene-based polymers," Zeitschrift für Naturforschung C - A Journal of Biosciences, vol. 74, no. 3-4, pp. 90-99, 2019.
[22]
A. Stamm et al., "Chemo- enzymatic pathways toward pinene- based renewable materials," Green Chemistry, vol. 21, no. 10, pp. 2720-2731, 2019.
[23]
A. Biundo et al., "Switched reaction specificity in polyesterases towards amide bond hydrolysis by enzyme engineering," RSC Advances, vol. 9, no. 62, pp. 36217-36226, 2019.
[24]
N. Hendrikse et al., "Ancestral diterpene cyclases show increased thermostability and substrate acceptance," The FEBS Journal, vol. 285, no. 24, pp. 4660-4673, 2018.
[25]
P.-O. Syrén, "Enzymatic Hydrolysis of Tertiary Amide Bonds by anti Nucleophilic Attack and Protonation," Journal of Organic Chemistry, vol. 83, no. 21, pp. 13543-13548, 2018.
[26]
C. Gustafsson et al., "MD Simulations Reveal Complex Water Paths in Squalene–Hopene Cyclase: Tunnel-Obstructing Mutations Increase the Flow of Water in the Active Site," ACS Omega, vol. 2, no. 11, pp. 8495-8506, 2017.
[27]
A. Eriksson, C. Kürten and P.-O. Syrén, "Protonation-Initiated Cyclization by a ClassII Terpene Cyclase Assisted by Tunneling," ChemBioChem, vol. 18, no. 23, pp. 2301-2305, 2017.
[28]
N. M. Hendrikse et al., "Redesign of biosynthetic enzymes using ancestral sequence reconstruction," The FEBS Journal, vol. 284, pp. 86-87, 2017.
[29]
M. J. Fink and P.-O. Syrén, "Redesign of water networks for efficient biocatalysis," Current opinion in chemical biology, vol. 37, pp. 107-114, 2017.
[30]
J. Fagerland et al., "Template-assisted enzymatic synthesis of oligopeptides from a polylactide chain," Biomacromolecules, vol. 18, no. 12, pp. 4271-4280, 2017.
[31]
C. Kürten, B. Carlberg and P.-O. Syren, "Mechanism-Guided Discovery of an Esterase Scaffold with Promiscuous Amidase Activity," Catalysts, vol. 6, no. 6, 2016.
[32]
P.-O. Syrén et al., "Squalene-hopene cyclases : evolution, dynamics and catalytic scope," Current opinion in structural biology, vol. 41, pp. 73-82, 2016.
[33]
S. Hammer, P.-O. Syrén and B. Hauer, "Substrate Pre-Folding and Water Molecule Organization Matters for Terpene Cyclase Catalyzed Conversion of Unnatural Substrates," ChemistrySelect, vol. 1, pp. 3589-3593, 2016.
[34]
C. Kürten and P.-O. Syren, "Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes," Journal of Visualized Experiments, no. 107, 2016.
[35]
P. Hendil-Forssell, M. Martinelle and P.-O. Syren, "Exploring water as building bricks in enzyme engineering," Chemical Communications, vol. 51, no. 97, pp. 17221-17224, 2015.
[36]
C. Kürten, M. Uhlén and P.-O. Syrén, "Overexpression of functional human oxidosqualene cyclase in Escherichia coli," Protein Expression and Purification, vol. 115, pp. 46-53, 2015.
[37]
P.-O. Syrén et al., "Entropy is Key to the Formation of Pentacyclic Terpenoids by Enzyme-Catalyzed Polycyclization," Angewandte Chemie International Edition, vol. 53, no. 19, pp. 4845-4849, 2014.
[38]
P.-O. Syrén et al., "Proton Shuttle Mechanism in the Transition State of Lipase-Catalyzed N-Acylation of Amino Alcohols," ChemCatChem, vol. 5, no. 7, pp. 1842-1853, 2013.
[39]
S. C. Hammer et al., "Squalene hopene cyclases : highly promiscuous and evolvable catalysts for stereoselective CC and CX bond formation," Current opinion in chemical biology, vol. 17, no. 2, pp. 293-300, 2013.
[40]
M. Seitz et al., "Synthesis of Heterocyclic Terpenoids by Promiscuous Squalene-Hopene Cyclases," ChemBioChem, vol. 14, no. Copyright (C) 2013 American Chemical Society (ACS). All Rights Reserved., pp. 436-439, 2013.
[41]
P.-O. Syren, "The solution of nitrogen inversion in amidases," The FEBS Journal, vol. 280, no. 13, pp. 3069-3083, 2013.
[42]
P.-O. Syrén et al., "Esterases with an Introduced Amidase-Like Hydrogen Bond in the Transition State Have Increased Amidase Specificity," ChemBioChem, vol. 13, no. 5, pp. 645-648, 2012.
[43]
S. C. Hammer et al., "Stereoselective Friedel-Crafts alkylation catalyzed by squalene hopene cyclases," Tetrahedron, vol. 68, no. Copyright (C) 2013 American Chemical Society (ACS). All Rights Reserved., pp. 7624-7629, 2012.
[44]
P.-O. Syrén and K. Hult, "Amidases have a hydrogen bond that facilitates nitrogen inversion but esterases have not," ChemCatChem, vol. 3, no. 5, pp. 853-860, 2011.
[45]
K. Engström et al., "Mutated variant of Candida antarctica lipase B in (S)-selective dynamic kinetic resolution of secondary alcohols," Organic and biomolecular chemistry, vol. 9, no. 1, pp. 81-82, 2011.
[46]
P.-O. Syren et al., "Increased activity of enzymatic transacylation of acrylates through rational design of lipases," Journal of Molecular Catalysis B : Enzymatic, vol. 65, no. 1-4, pp. 3-10, 2010.
[47]
M. Vallin, P.-O. Syrén and K. Hult, "Mutant Lipase-Catalyzed Kinetic Resolution of Bulky Phenyl Alkyl sec-Alcohols : A Thermodynamic Analysis of Enantioselectivity," ChemBioChem, vol. 11, no. 3, pp. 411-416, 2010.
[48]
Z. Marton et al., "Mutations in the stereospecificity pocket and at the entrance of the active site of Candida antarctica lipase B enhancing enzyme enantioselectivity," Journal of Molecular Catalysis B : Enzymatic, vol. 65, no. 1-4, pp. 11-17, 2010.
[49]
P.-O. Syrén and K. Hult, "Substrate Conformations Set the Rate of Enzymatic Acrylation by Lipases," ChemBioChem, vol. 11, no. 6, pp. 802-810, 2010.
[50]
P.-O. Syren et al., "Milligram scale parallel purification of plasmid DNA using anion-exchange membrane capsules and a multi-channel peristaltic pump," Journal of chromatography. B, vol. 856, pp. 68-74, 2007.
Chapters in books
[51]
I. V. Pavlidis, N. Hendrikse and P.-O. Syrén, "Computational Techniques for Efficient Biocatalysis," in Modern Biocatalysis : Advances Towards Synthetic Biological Systems, Gavin Williams, Mélanie Hall Ed., : Royal Society of Chemistry, 2018, pp. 119-152.
[52]
P.-O. Syrén, "Understanding esterase and amidase reaction specificities by molecular modelling," in Understanding enzymes; Function, Design, Engineering and Analysis, : Pan Standford Publishing, 2016, p. 523.
Non-peer reviewed
Articles
[53]
F. Cadet et al., "Editorial : Machine learning, epistasis, and protein engineering: From sequence-structure-function relationships to regulation of metabolic pathways," Frontiers in Molecular Biosciences, vol. 9, 2022.
[54]
W. Farhat et al., "Enzymatic route for the synthesis of norcamphor lactone and its polymerization for applications as thermo-sensitive networks," Abstracts of Papers of the American Chemical Society, vol. 258, 2019.
[55]
L. Fogelström et al., "New chemo-enzymatic pathways for sustainable terpene-based polymeric materials," Abstracts of Papers of the American Chemical Society, vol. 257, 2019.
[56]
E. Malmström et al., "Sustainable terpene-based polymeric materials," Abstracts of Papers of the American Chemical Society, vol. 257, 2019.
[57]
A. Biundo et al., "Increasing amide acceptance on a polyester-hydrolyzing enzyme," New Biotechnology, vol. 33, pp. S105-S105, 2016.
[58]
P.-O. Syrén and K. Hult, "Least-motion mechanism in enzyme catalysis," The FEBS Journal, vol. 277, pp. 263-263, 2010.
Chapters in books
[59]
P.-O. Syrén, "Understanding esterase and amidase reaction specificities by molecular modeling," in Understanding Enzymes: Function, Design, Engineering and Analysis, : Pan Stanford Publishing, 2016, pp. 523-558.
Theses
[60]
P.-O. Syrén, "On electrostatic effects, minimal motion and other catalytic strategies used by enzymes," Doctoral thesis Stockholm : KTH Royal Institute of Technology, Trita-BIO-Report, 14, 2011.
Other
[61]
E. Sporre et al., "Metabolite interactions in the bacterial Calvin cycle and implications for flux regulation," (Manuscript).
[62]
J. Engström et al., "Cationic latexes of bio‐based hydrophobicmonomer Sobrerol methacrylate (SobMA)," (Manuscript).
[63]
X. Lopez-Lorenzo, R. Ganapathy and P.-O. Syrén, "Conformational Selection in Enzyme-Catalyzed Depolymerization of Bio-based Polyesters," (Manuscript).
[64]
X. Lopez-Lorenzo et al., "Degradation of PET microplastic particles to monomers in human serum by PETase," (Manuscript).
[65]
P.-O. Syrén et al., "Design, structure and plasma binding of ancestral β-CoV scaffold antigens," (Manuscript).
[66]
[67]
K. Schriever et al., "Engineering of ancestor as a tool to elucidate structure, mechanism and specificity of extant terpene cyclase," (Manuscript).
[68]
[69]
E. Sporre et al., "Metabolite interactions in the bacterial Calvin cycle and implications for flux regulation," (Manuscript).
[70]
K. Schriever et al., "Modulating activation entropyand enthalpy of human oxidosqualene cyclase reaction by tunnel mutagenesis," (Manuscript).
[71]
A. Stamm et al., "Pinene-based oxidative synthetic toolbox for scalable polyester synthesis," (Manuscript).
[72]
P.-O. Syrén et al., "Proton transfer in amino alcohols in transition state of lipase catalyzed N-acylation.," (Manuscript).
[73]
C. Hedfors et al., "Selectivity towards itaconic acid esters by Candida antarctica lipase B and variants," (Manuscript).
Latest sync with DiVA:
2024-12-08 02:03:42