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Publications

50 latest publications

[1]
Tu, W., Tobin, R. A., Abdelrazeq, L., Guite, K., Al-Khalili Szigyarto, C., Tsonaka, R. ... Dang, U. J. (2026). MDBiomarkers : A queryable biomarkers database integrating multiple serum and tissue datasets for Duchenne muscular dystrophy. JOURNAL OF NEUROMUSCULAR DISEASES.
[2]
Johansson, C., Boehler, J. F., Brown, K. J., Jimenez-Requena, A., Hober, A., Edfors, F. ... Al-Khalili Szigyarto, C. (2026). Quantification of a serum titin fragment reflects dystrophin restoration in mdx mice and disease severity in patients with dystrophinopathies. Journal of Neuromuscular Diseases.
[3]
Gkouma, S., Påvenius, L., Gustafsson, L., Panagiotis Tasiopoulos, C., Charbonneau, A., Upadhyay, S. ... Hedhammar, M. (2026). FN-silk membrane enables alveologenesis processes and self-organization of the H441 epithelial cell line into native-like alveolar morphology. Scientific Reports, 16(1).
[4]
Suominen, M. I., Fagerlund, K. M., Ristola, M., Zdrojewska, J., Diao, Y., Norström, C. ... Maki-Jouppila, J. H. (2026). Preclinical efficacy of a bispecific NK cell engager studied using a humanized multiple myeloma mouse model. Cancer Research, 86(7_Supplement), 1598-1598.
[5]
Karrani, S., Källén, A., Collodet, C., Ducommun, S., Widhe, M. & Hedhammar, M. (2026). The Use of FN-Silk Networks as Extracellular Matrix-Mimicking Support for 3D In Vitro Breast Cancer Models Improved the Model's Reproducibility in Drug Sensitivity. Medcomm Biomaterials and Applications, 5(2).
[6]
Mestre Borras, A., Mehari, H., Ståhl, S. & Löfblom, J. (2026). Engineering affibody domains as anti-idiotypic masks for nivolumab-based prodrugs. Protein Engineering Design & Selection, 39.
[7]
Jönsson, M., Hamnqvist, D., Dieminger, N., Nagy, T. M., Friberg, O., Wolf-Watz, M. & Hober, S. (2026). Calcium as a molecular switch: Gentle antibody-purification through directed evolution of Protein G. Separation and Purification Technology, 398.
[8]
Wu, S., Chandel, S., Bryzgalova, G., Efstathopoulos, P., Blust, K., Zhao, C. ... Lanner, F. (2026). An optimized protocol for efficient derivation of pancreatic islets from multiple human pluripotent stem cell lines. Stem Cell Reports, 21(5).
[9]
Laurén, I., Kostakis, A., Lord, M., Björklund, E., Wang, X., Tari, P. S. ... Mangsbo, S. (2026). Optimizing T cell responses of targeted peptide antigen delivery by modulating antigen processing through amino acid exchange. International Journal of Biological Macromolecules, 352.
[10]
Jensen, K. T., Almeida, A. V., Rönning, S., Karlander, M., Nielsen, N. S., Thøgersen, I. B. ... Harwood, S. L. (2026). Antagonist nanobodies prevent protease inhibition by CD109. Journal of Biological Chemistry, 302(3).
[11]
Abouzayed, A., Olsson, H., Papadopoulos, N., Mitran, B., Mallapura, H., Akter, T. ... Eriksson, O. (2026). Increased affinity by dimerization of radiolabeled Affibody molecule ATH001 targeting PDGFRβ. EJNMMI Radiopharmacy and Chemistry, 11(1).
[12]
Dölle, M., Hervé, M., Königsson, S., Thorwid, P., Rockberg, J. & Chotteau, V. (2026). Efficiency and scalability in harvesting mammalian cell cultures : A scale-down approach to continuous centrifugation. Journal of Biotechnology, 411, 89-101.
[13]
Thorell, H., Rönning, S., Daoda, O., Chotteau, V., Rockberg, J. & Malm, M. (2026). Automated plasmid purification system enables increased AAV production. New Biotechnology, 93, 143-154.
[14]
Meyer, A., Mayer, L. M., Gustafsson, L., Eriksson, J., Klein, K., Büttner, F. A. ... Artursson, P. (2026). Recombinant spider silk membranes promote human renal epithelial differentiation and function. Biofabrication, 18(2).
[15]
Zhang, Q., Murthy, A. V. & Mim, C. (2026). Exploration of a workflow for the classification and identification of co-purified protein complexes yields new structures and multiple MSP assembly states. PLOS ONE, 21(1).
[16]
Teworte, S., Behrens, M. C., Widhe, M., Gurzeler, L.-A., Hedhammar, M. & Luciani, P. (2026). A Fibronectin (FN)-Silk 3D Cell Culture Model as a Screening Tool for Repurposed Antifibrotic Drug Candidates for Endometriosis. Small, 22(16).
[17]
Clementel, D., Arrías, P. N., Mozaffari, S., Osmanli, Z., Castro, X. A., Curators, R. ... Monzon, A. M. (2025). RepeatsDB in 2025 : expanding annotations of structured tandem repeats proteins on AlphaFoldDB. Nucleic Acids Research, 53(D1), D575-D581.
[18]
Hjelm, L. C., Paslawski, W., Lendel, C., Svedmark, S. F., Svenningsson, P., Ståhl, S. ... Löfblom, J. (2025). Engineered sequestrins inhibit aggregation of pathogenic alpha-synuclein mutants. Frontiers in Immunology, 16.
[19]
Rockberg, J., Nilvebrant, J., Malm, M. & Thalén, N. (2025). Preface. In Methods in Molecular Biology (pp. v-vi). Humana Press Inc.
[20]
Rockberg, J., Nilvebrant, J., Malm, M., Thalén, N. (Eds.). (2025). Epitope Mapping Protocols . Springer Nature.
[21]
Thalén, N., Karlander, M., Malm, M. & Rockberg, J. (2025). Mammalian Cell Display with Automated Oligo Design and Library Assembly Allows for Rapid Residue Level Conformational Epitope Mapping. In Methods in Molecular Biology (pp. 133-146). Springer Nature.
[22]
Nilvebrant, J. (2025). Binding Kinetics and Epitope Binning Using Surface Plasmon Resonance. In Methods in Molecular Biology (pp. 277-295). Springer Nature.
[23]
Volk, A.-L. & Rockberg, J. (2025). Mapping of Antibody Structural Epitopes Using Bacterial Cell Surface Display of Folded Domains. In Methods in Molecular Biology (pp. 163-187). Springer Nature.
[24]
Volk, A.-L., Hu, F. J., Malm, M. & Rockberg, J. (2025). Epitope Mapping of Antibodies Using Bacterial Cell Surface Display of Gene Fragment Libraries. In Methods in Molecular Biology (pp. 147-162). Springer Nature.
[25]
Nilvebrant, J., Thalén, N. B., Rockberg, J. & Malm, M. (2025). An Overview of Epitopes and Methods for Antibody Epitope Mapping. In Methods in Molecular Biology (pp. 1-11). Springer Nature.
[26]
Tolmachev, V., Papalanis, E., Nilvebrant, J., Oroujeni, M., Li, R., Bezverkhniaia, E. ... Nygren, P.-Å. (2025). Feasibility of imaging CEACAM5 expressing xenografts using radiolabeled affibody molecules. Nuclear Medicine and Biology, 150-151, 109293.
[27]
Ladd, B., Tunmats, S., Gräslund, T., Daramola, O., Rockberg, J. & Chotteau, V. (2025). Heterogeneity in an adeno-associated virus transfection-based production process limits the production efficiency. Scientific Reports, 15(1).
[28]
Ek, M., Nilvebrant, J., Nygren, P.-Å., Ståhl, S., Lindberg, H. & Löfblom, J. (2025). Design and development of a sortilin-targeting miniprotein for the treatment of FTD. Alzheimer's & Dementia : Journal of the Alzheimer's Association, 21(S5), 100961.
[29]
Jönsson, M., Möller, M., Schierholz, L., Dorka, N., Tegel, H., Lundberg, E. ... Hober, S. (2025). Engineered calcium-regulated affinity protein for efficient internalization and lysosomal toxin delivery. Proceedings of the National Academy of Sciences of the United States of America, 122(48).
[30]
Rinne, S. S., Yin, W., Li, R., Ding, H., Mestre Borras, A., Mahmod, C. ... Gräslund, T. (2025). Affibody-Derived Drug Conjugates Targeting The Epidermal Growth Factor Receptor Are Potent And Specific Cytotoxic Agents. ACS Pharmacology & Translational Science, 8(11), 3872-3885.
[31]
Ahmadiharchegani, F., Tobin, R. A., Degan, C., Naveed, A., Guglieri, M., Jimenez-Requena, A. ... Hathout, Y. (2025). Circulating protein biomarkers identified in two independent clinical trial cohorts of glucocorticoid-naive Duchenne muscular dystrophy patients. Scientific Reports, 15(1), 39997.
[32]
Masson, H. O., Di Giusto, P., Kuo, C. C., Malm, M., Lundqvist, M., Sivertsson, Å. ... Lewis, N. E. (2025). Deciphering the determinants of recombinant protein expression across the human secretome. Proceedings of the National Academy of Sciences of the United States of America, 122(41).
[33]
Mestre Borras, A., Mehari, H., Ståhl, S. & Löfblom, J. (2025). Engineering high-efficiency matriptase substrates using E. coli display for applications in prodrug activation. Cell Reports Methods, 5(6).
[34]
Keller, G., Widhe, M., Jansson, R., Vaisbourd, E., Pires, R. S. & Hedhammar, M. (2025). Recombinant spider silk functionalized with a CD40 agonist shows improved capability to activate human B cells in vitro - A novel module for cancer immunotherapy. International Journal of Biological Macromolecules, 327.
[35]
Nilvebrant, J., Moro, C. F., Papalanis, E., Novin, M. O., Ding, H., Li, R. ... Nygren, P.-Å. (2025). An anti-CEA affibody showing high-definition staining in human pancreatic cancer tissue sections and selective tumor targeting in vivo. Translational Oncology, 61.
[36]
Källén, A., Taebnia, N., Widhe, M., Lauschke, V. M. & Hedhammar, M. (2025). 3D Culture in Functionalized FN-Silk Networks Facilitate Proliferation, Differentiation and Phenotypic Stability of Mature Human Primary Cells and Stem Cells. Biotechnology and Bioengineering, 122(9), 2522-2534.
[37]
Möller, M., Jönsson, M., Lundqvist, M., Rockberg, J., Löfblom, J., Tegel, H. & Hober, S. (2025). Deep sequencing combined with high-throughput screening enables efficient development of a pH-dependent high-affinity binding domain targeting HER3. Protein Science, 34(8).
[38]
Zhang, Y., Sundäng Peters, E., Daramola, O., Tucker, T. A., Rockberg, J., Hatton, D. & Chotteau, V. (2025). Intensification of rAAV Production Based on HEK293 Cell Transient Transfection. Biotechnology Journal, 20(6).
[39]
Giang, K. A., Nilvebrant, J., Liu, H., Káradóttir, H., Diao, Y., Svensson Gelius, S. & Nygren, P.-Å. (2025). An Anti-BCMA Affibody Affinity Protein for Therapeutic and Diagnostic Use in Multiple Myeloma. International Journal of Molecular Sciences, 26(11).
[40]
Thorell, H., Karlander, M., Thalén, N., Fresk, M., Villacañas González, M. D. C., Jung, T. ... Rockberg, J. (2025). Selective DNA delivery through amodular AAV platform utilising Affibody binding domains. Human Gene Therapy, 36(3-4), E211-E212.
[41]
Arrías, P. N., Esnal, M. R. & Malm, M. (2025). Imaging the rAAV manufacturing process : assessing the subcellular localisation of capsids during production. Human Gene Therapy, 36(3-4), E187-E188.
[42]
Cristina, V., Giulia, R., Yin, W., Mathilde, H., Dipambita, R., Gräslund, T. ... Stefano, R. (2025). Affibodies as valuable tool to prevent β2m aggregation under lysosomal-like conditions. Biology Direct, 20(1).
[43]
Johansson, C., Schrama, E. J., Kotol, D., Hober, A., Koeks, Z., van de Velde, N. M. ... Al-Khalili Szigyarto, C. (2025). Contrasting Becker and Duchenne muscular dystrophy serum biomarker candidates by using data independent acquisition LC-MS/MS. Skeletal Muscle, 15(1).
[44]
Rönning, S., Thorell, H., Malm, M. & Rockberg, J. (2025). Automated plasmid purification can reducemanual labour and increase titres in AAV production. Human Gene Therapy, 36(3-4), E179-E180.
[45]
Hanitrarimalala, V., Prgomet, Z., Hedhammar, M., Tassidis, H. & Wingren, A. G. (2025). In vitro 3D modeling of colorectal cancer: the pivotal role of the extracellular matrix, stroma and immune modulation. Frontiers in Genetics, 16.
[46]
Zimmermann, I., Dölle, M., Friberg, O., Atallah, E., Eilts, F., Chotteau, V. ... Berensmeier, S. (2025). Calcium-dependent magnetic separation: A novel approach for the integrated processing of high-quality mAbs. Separation and Purification Technology, 371.
[47]
Sadler, C. J., Creamer, A., Giang, K. A., Darmawan, K. K., Shamsabadi, A., Richards, D. A. ... Stevens, M. M. (2025). Adding a Twist to Lateral Flow Immunoassays : A Direct Replacement of Antibodies with Helical Affibodies, from Selection to Application. Journal of the American Chemical Society, 147(14), 11925-11940.
[48]
Westerberg, C., Mestre Borras, A., Ståhl, S. & Löfblom, J. (2025). Affibody-based HER2 prodrug shows conditional cytotoxic effect on HER2-positive cancer cells. Biochemical and Biophysical Research Communications - BBRC, 758.
[49]
Zimmermann, I., Eilts, F., Galler, A. S., Bayer, J., Hober, S. & Berensmeier, S. (2025). Immobilizing calcium-dependent affinity ligand onto iron oxide nanoparticles for mild magnetic mAb separation. Biotechnology Reports, 45.
[50]
Davoodi, S., Ornithopoulou, E., J. Gavillet, C., Davydok, A., Roth, S. V., Lendel, C. & Lundell, F. (2025). Confinement induced self-assembly of protein nanofibrils probed by microfocus X-ray scattering. Journal of Physical Chemistry B, 129(3), 1070-1081.