Elisa Pin

Our research focuses on characterizing autoantibody profiles in autoimmune and inflammatory conditions, with the ultimate goal of identifying novel autoantibodies with clinical utility for improving disease diagnosis and stratification. Additionally, I explore the specificity of these novel autoantibodies as well as the specificity of established autoantibody biomarkers.

This work is supported by affiliation to the Affinity Proteomics Div at KTH-SciLifeLab, where, over the past fifteen years, planar and bead-based antigen array technologies have been developed to enable highly multiplexed and high-throughput detection and epitope mapping of autoantibodies. Our close collaboration with the Human Protein Atlas grants access to an extensive library of protein fragments representing nearly all human proteins, which we utilize as antigens in highly multiplexed autoantibody analyses.

Beyond autoantibody profiling, I contribute to research aimed at characterizing the plasma protein landscape of autoimmune diseases. This is achieved through the application of Olink and bead-based array technologies.

Currently, my research focuses on conditions such as systemic sclerosis, ANCA-associated vasculitis, sarcoidosis, myositis, and fibrosis. These projects are conducted in close collaboration with leading national and international clinicians to ensure clinical relevance and impact.

Affiliation:
Div of Affinity Proteomics
Dept of Protein Science
School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH)
KTH Royal Institute of Technology
SciLifeLab

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Group members:

Charlotta Preger, postdoc

Maria Aspenberg, research engineer

Ceke Hellström, research engineer

Eni Andersson, research engineer

Metta Berenpas, Erasmus student, Radboud University, The Netherlands

Supervised students:

Shaghayegh Bayati, PhD student (2020-2023), KTH

Maria Aspenberg, master student, KTH (2024)

Federica Ress, Erasmus student (2022), University of Trento, Italy

Emmie Pohjanen, master student (2020), KTH

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Research funding:

• RELapses prevention in chronic autoimmune disease: common mechanisms and co-morbidities (RELENT) consortium. European Union’s Horizon 2020

•HEalth data Linkage for ClinicAL benefit (HELICAL) training network. European Union’s Horizon 2020, under the Marie Skłodowska-Curie programme

•Personalisation of Relapse Risk in Autoimmunity (PARADISE) consortium. ERAPerMed

•Hjärt-Lungfonden. "The lung fibrosis associated autoantibody repertoire in systemic sclerosis"

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Selected publications:

• Bayati S, Nazeer J, Ng J, George AM, Hayes M, Little MA, Nilsson P, Pin E. Autoantibodies towards HFE and SYT5 in anti-neutrophil cytoplasm antibody-associated vasculitis relapse. Rheumatology (Oxford). 2024 Oct 14:keae540. doi: 10.1093/rheumatology/keae540.

• Mescia F, Bayati S, Brouwer E, Heeringa P, Toonen EJM, Beenes M, Ball MJ, Rees AJ, Kain R, Lyons PA, Nilsson P, Pin E. Autoantibody Profiling and Anti-Kinesin Reactivity in ANCA-Associated Vasculitis. Int J Mol Sci. 2023 Oct 19;24(20):15341. doi: 10.3390/ijms242015341.

• Geroldinger-Simić M, Bayati S, Pohjanen E, Sepp N, Nilsson P, Pin E.  Autoantibodies against PIP4K2B and AKT3 Are Associated with Skin and Lung Fibrosis in Patients with Systemic Sclerosis. Int J Mol Sci. 2023 Mar 15;24(6):5629. doi: 10.3390/ijms24065629.

• Olofsson J, Hellström C, Andersson E, Yousef J, Skoglund L, Sjöberg R, Månberg A, Nilsson P, Pin E. Array-Based Multiplex and High-Throughput Serology Assays. Methods Mol Biol. 2023;2628:535-553. doi: 10.1007/978-1-0716-2978-9_31.

• Alkharaan H, Bayati S, Hellström C, Aleman S, Olsson A, Lindahl K, Bogdanovic G, Healy K, Tsilingaridis G, De Palma P, Hober S, Månberg A, Nilsson P, Pin E, Sällberg Chen M. Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys. J Infect Dis. 2021 Aug 2;224(3):407-414. doi: 10.1093/infdis/jiab256.