Publikationer av Per-Åke Nygren
Refereegranskade
Artiklar
[1]
K. A. Giang et al., "Affibody-based hBCMA x CD16 dual engagers for NK cell-mediated killing of multiple myeloma cells," New Biotechnology, vol. 77, s. 139-148, 2023.
[2]
T. Schulte et al., "Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH," Open Biology, vol. 13, no. 5, 2023.
[3]
R. Cena-Diez et al., "Naturally occurring dipeptide from elite controllers with dual anti-HIV-1 mechanism," International Journal of Antimicrobial Agents, vol. 61, no. 5, s. 106792, 2023.
[4]
K. A. Giang, P.-Å. Nygren och J. Nilvebrant, "Selection of Affibody Affinity Proteins from Phagemid Libraries," Methods in Molecular Biology, vol. 2702, s. 373-392, 2023.
[5]
A. C. L. Mortensen et al., "Selection, characterization and in vivo evaluation of novel CD44v6-targeting antibodies for targeted molecular radiotherapy," Scientific Reports, vol. 13, no. 1, 2023.
[6]
J. Persson et al., "Discovery, optimization and biodistribution of an Affibody molecule for imaging of CD69," Scientific Reports, vol. 11, no. 1, 2021.
[7]
W. Yu et al., "Efficient Labeling of Native Human IgG by Proximity-Based Sortase-Mediated Isopeptide Ligation," Bioconjugate chemistry, vol. 32, no. 6, s. 1058-1066, 2021.
[8]
J. Lindberg et al., "Progress and Future Directions with Peptide-Drug Conjugates for Targeted Cancer Therapy," Molecules, vol. 26, no. 19, 2021.
[9]
T. Ozawa et al., "Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice," iScience, vol. 24, no. 5, 2021.
[10]
R. W. Hartmann et al., "The Wittig bioconjugation of maleimide derived, water soluble phosphonium ylides to aldehyde-tagged proteins," Organic and biomolecular chemistry, vol. 19, no. 47, s. 10417-10423, 2021.
[11]
T. Schulte et al., "Assigned NMR backbone resonances of the ligand-binding region domain of the pneumococcal serine-rich repeat protein (PsrP-BR) reveal a rigid monomer in solution," Biomolecular NMR Assignments, 2020.
[12]
A. D. Duru et al., "Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination," PLoS Pathogens, vol. 16, no. 5, 2020.
[13]
M. Lundqvist et al., "Chromophore pre-maturation for improved speed and sensitivity of split-GFP monitoring of protein secretion," Scientific Reports, vol. 9, 2019.
[14]
L. C. Hjelm et al., "Lysis of Staphylococcal Cells by Modular Lysin Domains Linked via a n-covalent Barnase-Barstar Interaction Bridge," Frontiers in Microbiology, vol. 10, 2019.
[15]
K. Subramanian et al., "Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival," Nature Microbiology, vol. 4, no. 1, s. 62-70, 2019.
[16]
I. Hafstrand et al., "Successive crystal structure snapshots suggest the basis for MHC class I peptide loading and editing by tapasin," Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 11, s. 5055-5060, 2019.
[17]
F. Yu, V. Alesand och P.-Å. Nygren, "Site-Specific Photoconjugation of Beta-Lactamase Fragments to Monoclonal Antibodies Enables Sensitive Analyte Detection via Split-Enzyme Complementation," Biotechnology Journal, vol. 13, no. 7, 2018.
[18]
S. Ståhl et al., "Affibody Molecules in Biotechnological and Medical Applications," Trends in Biotechnology, vol. 35, no. 8, s. 691-712, 2017.
[19]
T. Schulte et al., "The BR domain of PsrP interacts with extracellular DNA to promote bacterial aggregation; structural insights into pneumococcal biofilm formation," Scientific Reports, vol. 6, 2016.
[20]
F. Yu et al., "An affibody-adalimumab hybrid blocks combined IL-6 and TNF-triggered serum amyloid A secretion in vivo," mAbs, vol. 6, no. 6, s. 1598-1607, 2014.
[21]
S. Shibasaki et al., "Inhibitory effects of H-Ras/Raf-1–binding affibody molecules on synovial cell function," AMB Express, vol. 4, no. 82, 2014.
[22]
R. Jansson et al., "Recombinant Spider Silk Genetically Functionalized with Affinity Domains," Biomacromolecules, vol. 15, no. 5, s. 1696-1706, 2014.
[23]
H. Uchtenhagen et al., "Proline substitution independently enhances H-2D(b) complex stabilization and TCR recognition of melanoma-associated peptides," European Journal of Immunology, vol. 43, no. 11, s. 3051-3060, 2013.
[24]
M. Neiman et al., "Selectivity analysis of single binder assays used in plasma protein profiling," Proteomics, vol. 13, no. 23-24, s. 3406-3410, 2013.
[25]
F. Yu, P. Järver och P.-Å. Nygren, "Tailor-Making a Protein A-Derived Domain for Efficient Site-Specific Photocoupling to Fc of Mouse IgG(1)," PLOS ONE, vol. 8, no. 2, s. e56597, 2013.
[26]
F. Akter et al., "Detection of Antigens Using a Protein-DNA Chimera Developed by Enzymatic Covalent Bonding with phiX Gene A," Analytical Chemistry, vol. 84, no. 11, s. 5040-5046, 2012.
[27]
E. B. Allerbring et al., "Unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics," European Journal of Immunology, vol. 42, no. 11, s. 2990-3000, 2012.
[28]
P.-Å. Nygren, "Affinity ligands from biological combinatorial libraries," Methods of biochemical analysis, vol. 54, s. 269-78, 2011.
[29]
H. Wållberg et al., "Affinity recovery of eight HER2-binding affibody variants using an anti-idiotypic affibody molecule as capture ligand," Protein Expression and Purification, vol. 76, no. 1, s. 127-135, 2011.
[30]
S. Grimm, S. Salahshour och P.-Å. Nygren, "Monitored whole gene in vitro evolution of an anti-hRaf-1 affibody molecule towards increased binding affinity," New Biotechnology, vol. 29, no. 5, s. 534-542, 2011.
[31]
S. Grimm, F. Yu och P.-Å. Nygren, "Ribosome Display Selection of a Murine IgG(1) Fab Binding Affibody Molecule Allowing Species Selective Recovery Of Monoclonal Antibodies," Molecular Biotechnology, vol. 48, no. 3, s. 263-276, 2011.
[32]
P.-Å. Löfdahl och P.-Å. Nygren, "Affinity maturation of a TNF-α binding affibodymolecule by Darwinian survival selection," Biotechnology and applied biochemistry, vol. 55, s. 111-120, 2010.
[33]
S. Grimm et al., "Selection and characterisation of affibody molecules inhibiting the interaction between Ras and Raf in vitro," NEW BIOTECHNOL, vol. 27, no. 6, s. 766-773, 2010.
[34]
E. Vernet et al., "Affibody-mediated retention of the epidermal growth factor receptor in the secretory compartments leads to inhibition of phosphorylation in the kinase domain," New biotechnology, vol. 25, no. 6, s. 417-423, 2009.
[35]
P.-Å. Löfdahl et al., "Selection of TNF-alpha binding affibody molecules using a beta-lactamase protein fragment complementation assay," New Biotechnology, vol. 26, no. 5, s. 251-259, 2009.
[36]
E. Vernet et al., "Affinity-based entrapment of the HER2 receptor in the endoplasmic reticulum using an affibody molecule," Journal of immunological methods, vol. 338, s. 1-6, 2008.
[37]
P.-Å. Nygren, "Alternative binding proteins : Affibody binding proteins developed from a small three-helix bundle scaffold," The FEBS Journal, vol. 275, no. 11, s. 2668-2676, 2008.
[38]
A. Jonsson et al., "Engineering of a femtomolar affinity binding protein to human serum albumin," Protein Engineering Design & Selection, vol. 21, no. 8, s. 515-527, 2008.
[39]
B. Renberg et al., "Affibody molecules in protein capture microarrays : Evaluation of multidomain ligands and different detection formats," Journal of Proteome Research, vol. 6, no. 1, s. 171-179, 2007.
[40]
N. Bandmann och P.-Å. Nygren, "Combinatorial expression vector engineering for tuning of recombinant protein production in Escherichi coli," Nucleic Acids Research, vol. 35, no. 5, 2007.
[41]
S. Wagner et al., "Consequences of membrane protein overexpression in Escherichia coli," Molecular & Cellular Proteomics, vol. 6, no. 9, s. 1527-1550, 2007.
[42]
S. Myhre et al., "Decreased immune reactivity towards a knobless, affibody-targeted adenovirus type 5 vector," Gene Therapy, vol. 14, no. 4, s. 376-381, 2007.
[43]
M. J. Taussig et al., "ProteomeBinders : planning a European resource of affinity reagents for analysis of the human proteome," Nature Methods, vol. 4, no. 1, s. 13-17, 2007.
[44]
B. Renberg et al., "Affibody protein capture microarrays : synthesis and evaluation of random and directed immobilization of affibody molecules," Analytical Biochemistry, vol. 341, no. 2, s. 334-343, 2005.
[45]
T. Engfeldt et al., "Chemical Synthesis of Triple-Labelled Three-Helix Bundle Binding Proteins for Specific Fluorescent Detection of Unlabelled Protein," ChemBioChem (Print), vol. 6, no. 6, s. 1043-1050, 2005.
[46]
M. Wiklund et al., "Fluorescence-microscopy-based image analysis for analyte-dependent particle doublet detection in a single-step immuno agglutination assay," Analytical Biochemistry, vol. 338, no. 1, s. 90-101, 2005.
[47]
O. Nord, A. Gustrin och P.-Å. Nygren, "Fluorescent detection of beta-lactamase activity in living Escherichia coli cells via esterase supplementation," FEMS Microbiology Letters, vol. 242, no. 1, s. 73-79, 2005.
[48]
P. Henning et al., "Tumor cell targeted gene delivery by adenovirus 5 vectors carrying knobless fibers with antibody-binding domains," Gene Therapy, vol. 12, no. 3, s. 211-224, 2005.
[49]
P.-Å. Nygren och A. Skerra, "Binding proteins from alternative scaffolds," JIM - Journal of Immunological Methods, vol. 290, no. 1-2, s. 3-28, 2004.
[50]
C. Lendel et al., "Biophysical characterization of ZSPA-1-A phage-display selected binder to protein A," Protein Science, vol. 13, no. 8, s. 2078-2088, 2004.
[51]
B. Renberg et al., "Fluorescence resonance energy transfer-based detection of analytes using antiidiotypic affinity protein pairs," Analytical Biochemistry, vol. 334, no. 1, s. 72-80, 2004.
[52]
L. Lindholm et al., "Genetic re-targeting of adenovirus using a hyperstable scFv domain and an affibody (R) molecule against Her2/neu," Molecular Therapy, vol. 9, s. S250-S250, 2004.
[53]
M. Eklund et al., "Site-specific and reversible anchoring of active proteins onto cellulose using a cellulosome-like complex," Journal of Biotechnology, vol. 109, no. 3, s. 277-286, 2004.
[54]
J. Ronnmark et al., "Affibody-beta-galactosidase immunoconjugates produced as soluble fusion proteins in the Escherichia coli cytosol," JIM - Journal of Immunological Methods, vol. 281, no. 02-jan, s. 149-160, 2003.
[55]
E. Wahlberg et al., "An affibody in complex with a target protein: Structure and coupled folding.," Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 6, s. 3185-3190, 2003.
[56]
M. Linhult et al., "Evaluation of different linker regions for multimerization and coupling chemistry for immobilization of a proteinaceous affinity ligand," Protein Engineering, vol. 16, no. 12, s. 1147-1152, 2003.
[57]
M. Andersson et al., "Inclusion of a non-immunoglobulin binding protein in two-site ELISA for quantification of human serum proteins without interference by heterophilic serum antibodies," JIM - Journal of Immunological Methods, vol. 283, no. 02-jan, s. 225-234, 2003.
[58]
K. Sandstrom et al., "Inhibition of the CD28-CD80 co-stimulation signal by a CD28-binding affibody ligand developed by combinatorial protein engineering," Protein Engineering, vol. 16, no. 9, s. 691-697, 2003.
[59]
O. Nord, M. Uhlén och P.-Å. Nygren, "Microbead display of proteins by cell-free expression of anchored DNA," Journal of Biotechnology, vol. 106, no. 1, s. 1-13, 2003.
[60]
C. Lendel et al., "1H, 13C and 15N resonance assignments of an affibody-target complex," Journal of Biomolecular NMR, vol. 24, no. 3, s. 271-272, 2002.
[61]
S. Gräslund et al., "A novel affinity gene fusion system allowing protein A-based recovery of non-immunoglobulin gene products," Journal of Biotechnology, vol. 99, no. 1, s. 41-50, 2002.
[62]
M. Eklund et al., "Anti-idiotypic protein domains selected from protein A-based affibody libraries," Proteins : Structure, Function, and Bioinformatics, vol. 48, no. 3, s. 454-462, 2002.
[63]
J. Ronnmark et al., "Construction and characterization of affibody-Fc chimeras produced in Escherichia coli," JIM - Journal of Immunological Methods, vol. 261, no. 02-jan, s. 199-211, 2002.
[64]
P. Samuelson et al., "Display of proteins on bacteria," Journal of Biotechnology, vol. 96, no. 2, s. 129-154, 2002.
[65]
N. Bandmann et al., "Functional selection of phage displayed peptides for facilitated design of fusion tags improving aqueous two-phase partitioning of recombinant proteins," Journal of Biotechnology, vol. 93, no. 1, s. 1-14, 2002.
[66]
P. Henning et al., "Genetic modification of adenovirus 5 tropism by a novel class of ligands based on a three-helix bundle scaffold derived from Staphylococcal protein A," Human Gene Therapy, vol. 13, no. 12, s. 1427-1439, 2002.
[67]
J. Ronnmark et al., "Human immunoglobulin A (IgA)-specific ligands from combinatorial engineering of protein A," European Journal of Biochemistry, vol. 269, no. 11, s. 2647-2655, 2002.
[68]
T. Gräslund et al., "Integrated strategy for selective expanded bed ion-exchange adsorption and site-specific protein processing using gene fusion technology," Journal of Biotechnology, vol. 96, no. 1, s. 93-102, 2002.
[69]
T. Gräslund et al., "Integrated strategy for selective expanded bed ion-exchange adsorption and site-specific protein processing using gene fusion technology," Journal of Biotechnology, vol. 96, no. 1, s. 93-102, 2002.
[70]
T. Gräslund et al., "Strategy for highly selective ion-exchange capture using a charge-polarizing fusion partner," Journal of Chromatography A, vol. 942, no. 1-2, s. 157-166, 2002.
[71]
A. Karlstrom och P.-Å. Nygren, "Dual labeling of a binding protein allows for specific fluorescence detection of native protein," Analytical Biochemistry, vol. 295, no. 1, s. 22-30, 2001.
[72]
H. Wernérus et al., "Generation of metal-binding staphylococci through surface display of combinatorially engineered cellulose-binding domains," Applied and Environmental Microbiology, vol. 67, no. 10, s. 4678-4684, 2001.
[73]
S. Danielsen et al., "In vitro selection of enzymatically active lipase variants from phage libraries using a mechanism-based inhibitor," Gene, vol. 272, no. 02-jan, s. 267-274, 2001.
[74]
A. Fredriksson et al., "Labeling of human C-peptide by conjugation with N-succinimidyl-4- F-18 fluorobenzoate," Journal of labelled compounds & radiopharmaceuticals, vol. 44, no. 7, s. 509-519, 2001.
[75]
C. Andersson et al., "Mammalian cell production of a respiratory syncytial virus (RSV) candidate vaccine recovered using a product-specific affinity column," Biotechnology and applied biochemistry, vol. 34, s. 25-32, 2001.
[76]
K. Nord et al., "Recombinant human factor VIII-specific affinity ligands selected from phage-displayed combinatorial libraries of protein A," European Journal of Biochemistry, vol. 268, no. 15, s. 4269-4277, 2001.
[77]
J. Lehtio, T. T. Teeri och P.-Å. Nygren, "Alpha-amylase inhibitors selected from a combinatorial library of a cellulose binding domain scaffold," Proteins : Structure, Function, and Bioinformatics, vol. 41, no. 3, s. 316-322, 2000.
[78]
T. Gräslund et al., "Charge engineering of a protein domain to allow efficient ion-exchange recovery," Protein Engineering, vol. 13, no. 10, s. 703-709, 2000.
[79]
D. Legendre et al., "Display of active subtilisin 309 on phage : Analysis of parameters influencing the selection of subtilisin variants with changed substrate specificity from libraries using phosphonylating inhibitors," Journal of Molecular Biology, vol. 296, no. 1, s. 87-102, 2000.
[80]
N. Bandmann et al., "Genetic engineering of the Fusarium solani pisi lipase cutinase for enhanced partitioning in PEG-phosphate aqueous two-phase systems," Journal of Biotechnology, vol. 79, no. 2, s. 161-172, 2000.
[81]
P. Jonasson et al., "Integrated bioprocess for production of human proinsulin C-peptide via heat release of an intracellular heptameric fusion protein," Journal of Biotechnology, vol. 76, no. 03-feb, s. 215-226, 2000.
[82]
K. Nord et al., "Ligands selected from combinatorial libraries of protein A for use in affinity capture of apolipoprotein A-1(M) and Taq DNA polymerase," Journal of Biotechnology, vol. 80, no. 1, s. 45-54, 2000.
[83]
K. Berggren et al., "Partitioning of peptides and recombinant protein-peptide fusions in thermoseparating aqueous two-phase systems : effect of peptide primary structure," Journal of Chromatography B, vol. 743, no. 02-jan, s. 295-306, 2000.
[84]
S. Gulich et al., "Stability towards alkaline conditions can be engineered into a protein ligand," Journal of Biotechnology, vol. 80, no. 2, s. 169-178, 2000.
[85]
P. Nilsson et al., "Mutational scanning of PCR products by subtractive oligonucleotide hybridization analysis," BioTechniques, vol. 26, no. 2, s. 308-+, 1999.
[86]
P. Nilsson et al., "Quantitative Investigation of the Modular Primer Effect for DNA and Peptide Nucleic Acid Hexamers," Analytical Biochemistry, vol. 269, no. 1, s. 155-161, 1999.
[87]
D. O'Meara et al., "Capture of single-stranded DNA assisted by oligonucleotide modules," Analytical Biochemistry, vol. 255, no. 2, s. 195-203, 1998.
[88]
B. Persson et al., "Analysis of oligonucleotide probe affinities using surface plasmon resonance : A means for mutational scanning," Analytical Biochemistry, vol. 246, no. 1, s. 34-44, 1997.
[89]
P. Nilsson et al., "Detection of mutations in PCR products from clinical samples by surface plasmon resonance," Journal of Molecular Recognition, vol. 10, no. 1, s. 7-17, 1997.
[90]
T. Gräslund et al., "Production of a Thermostable DNA Polymerase by Site-Specific Cleavage of a Heat-Eluted Affinity Fusion Protein," Protein Expression and Purification, vol. 9, s. 125-132, 1997.
[91]
P. NILSSON et al., "REAL-TIME MONITORING OF DNA MANIPULATIONS USING BIOSENSOR TECHNOLOGY," Analytical Biochemistry, vol. 224, no. 1, s. 400-408, 1995.
Konferensbidrag
[92]
R. Jansson et al., "Recombinant Affinity Silk for Presentation of Active Protein Domains," i 26th European Conference on Biomaterials (ESB 2014), August 31 – September 3 2014, Liverpool, UK, 2014.
[93]
R. Jansson et al., "Recombinant spider silk with IgG-binding capacity used for cell capture," i 5th Annual Meeting of the Scandinavian Society for Biomaterials (ScSB 2012), May 8-9 2012, Uppsala, Sweden, 2012.
Icke refereegranskade
Artiklar
[94]
K. A. Giang et al., "Affibody-Based BCMA x CD16 Dual Engagers for Activation of NK Cells Towards Multiple Myeloma," Blood, vol. 140, s. 10699-10700, 2022.
[95]
K. Subramanian et al., "Pneumolysin interaction with the mannose receptor promotes pneumococcal invasion of the airways by blocking inflammatory responses," Scandinavian Journal of Immunology, vol. 90, no. 6, 2019.
[96]
E. B. Allerbring et al., "Structural and thermodynamic basis underlying in vivo reestablishment of T-cell recognition of a viral escape mutant," Molecular Immunology, vol. 68, no. 2, s. 151-151, 2015.
[97]
M. Sekiguchi et al., "Affibody Molecules Inhibiting The Interaction Between Ras And Raf Suppress The Proliferation And The Production Of Inflammatory Mediators By Synovial Cells," Annals of the Rheumatic Diseases, vol. 73, s. 848-848, 2014.
[98]
E. B. Allerbring et al., "The unexpected T-cell recognition of an altered peptide ligand is driven by reversed thermodynamics and an alternative structural hotspot," Immunology, vol. 135, s. 70-70, 2011.
[99]
J. Bourbeillon et al., "Minimum information about a protein affinity reagent (MIAPAR)," Nature Biotechnology, vol. 28, no. 7, s. 650-653, 2010.
Konferensbidrag
[100]
R. Jansson et al., "Towards the use of Bioactive Spider Silk in Affinity-Based Assays," i 2nd Workshop on Protein Materials (WPM 2017), March 9 – March 10 2017, KTH Royal Institute of Technology (KTH), Stockholm, Sweden, 2017.
Övriga
[101]
S. Grimm, S. Salahshour och P.-Å. Nygren, "Affinity maturation of an affibody molecule binding to human Raf-1 via non-targeted in vitro evolution," (Manuskript).
[102]
M. Lundqvist et al., "Chromophore prematuration for improved speed and sensitivity of split-GFP in vitro applications," (Manuskript).
[103]
N. Bandmann et al., "Exploring the use of a combinatorial expression vector library for facilitated soluble recombinant protein production," (Manuskript).
[104]
S. Grimm et al., "Selection and characterization of affibody molecules interfering with the interaction between Ras and Raf," (Manuskript).
[105]
S. Grimm et al., "Single domain affinity proteins for the detection of the genome organizer protein SATB1," (Manuskript).
[106]
F. Yu, V. Alesand och P.-Å. Nygren, "Site-specific photoconjugation of betalactamase split-protein fragments to monoclonal antibodies for homogeneous assay development," (Manuskript).
[107]
M. Neiman et al., "Validating the selectivity of antibodies used in multiplexed serum profiling via parallel immunocapture analysis," (Manuskript).
Patent
Patent
[108]
[109]
[110]
P.-Å. Nygren, M. Uhlén och O. Nord, "In vitro selection and optional identification of polypeptides using solid support carriers," au 761985-B2 (2003-06-12), 1999.
[111]
[112]
[113]
B. Nilsson, P.-Å. Nygren och M. Uhlén, "Bacterial receptor structures," au 696186B (1998-09-03), 1994.
[114]
H. Binz et al., "Method for enhancing the immunogenicity of an immunogenic compound or hapten, and use thereof for preparing vaccines," fr 2726471B1 (1997-01-31), 1994.
[115]
H. Binz et al., "Respiratory syncytial virus protein g expressed on bacterial membrane," fr 2726577B1 (1997-01-31), 1994.
[116]
S. Ståhl et al., "Recombinant DNA coding for signal peptide, selective interacting polypeptide and membrane anchoring sequence," us 5958736A (1999-09-28), 1991.
[117]
P.-Å. Nygren, "Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives," us 6267964 (2001-07-31), 1989.
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2024-04-21 04:41:12