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Mammalian Cell Technology

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The course teaches theory and methodology in the field of cell technology applied to animal cells.

Theoretical concepts included

  • basic techniques for animal cell culture in shake flasks and small-scale bioreactors
  • description and use of stable expression systems (cell lines)
  • overview of animal cell metabolism during cultivation, and its application in process design
  • aspects concerning commercial production such as patient safety and regulatory compliance
  • cells as products
  • application of knowledge from the course to develop and design culture processes

The student also receives practical training in

  • developing a process flow chart and strategy for cell culturing
  • choosing an appropriate cell line and expression system
  • developing a culture process for industrial application (scale-up constraints)
  • understanding the concept of "Good Manufacturing Practice" (GMP)
  • deciding on patient safety level and from that design a suitable process

Upon completion of the course, the course participant is expected to be able to
- demonstrate knowledge of key theoretical concepts and basic methodology regarding the cultivation process of animal cells, as well as skills in communicating, reviewing, analyzing, and discussing the course topics (ÖVN1)
- demonstrate the ability to use acquired knowledge to independently design, motivate and present strategies for animal cell culture process in order to manufacture a therapeutic biologics (PRO1)
- demonstrate a basic understanding of the possibilities and limitations of the application of animal cell-culture techniques for the development of therapeutic biologics, and reflect on their use in a sustainable and ethical perspective (PRO1)

Teachers