Links between in-vitro characterization, metal release, and nanotoxicity
The project combines material science, corrosion science, surface chemistry, and nanotoxicology. The research team is continuing an already established and successful collaboration between KTH and KI, which has the overall aim to find links between particle properties (such as bulk and surface composition, size, and different surface properties) and human toxicity.
Fundamental interdisciplinary studies are further focusing on the correlation of surface reactivity, protein interaction and toxicity of nano-sized and micron-sized metal-containing particles of relevance for e.g. occupational exposure scenarios and for the dispersion of engineered nanoparticles used in different consumer products. The research strategy provides an in-depth understanding of surface characteristics and reactivity, bioaccessibility, bioavailability, fate and toxicity of nano- and micron-sized metal particles. These activities are performed in close collaboration with colleagues at for example Karolinska Institutet, Institute for Environmental Medicine, and Stockholm University. See also the Mistra Environmental Nanosafety projec t . In-depth fundamental protein-metal surface interaction and surface reactivity studies are in addition performed in close collaboration with surface chemists within the division.
Funding
Swedish National Research council, Mistra