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John Löfblom

Professor of Combinatorial Protein Technology

Proteins are one of the most important molecules for life. Natural proteins exhibit an almost inconceivable diversity of structures, properties and functions. This richness is not only the key to the central role of proteins in all processes of life but has also given applications in a number of areas, from enzymes in detergents to new effective drugs. With the help of genetic techniques and advanced molecular-biotech methods, it is possible to create new artificial proteins with specific functions.

John Löfblom’s research seeks to develop new proteins that can be used in medical diagnostics, and as protein drugs in cancer and neurodegenerative diseases. He specializes in what is known as “directed evolution” or protein engineering. With the help of more or less random DNA mutations, large collections of combinatorial protein libraries are created. These libraries are then used to isolate new proteins with specific properties.

The ability of proteins to bind to other molecules has enabled the development of protein-based drugs, which in several cases has revolutionized the treatment of a number of diseases.

Belongs to: About KTH
Last changed: Apr 19, 2022
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