The research is focused on protein science, systems biology and precision medicine and ranges from basic research in human and microbial biology to more applied research, including clinical applications in cancer, infectious diseases, cardiovascular diseases, autoimmune diseases and neurobiology.
The group is leading an effort to systematically map the human proteome and transcriptome to create a Human Protein Atlas using antibodies and various omics technologies. This effort has so far resulted in the Tissue Atlas (2015) showing the distribution of proteins across human tissues and organs, the Cell Atlas (2016) showing the subcellular location of human proteins in single cells and the Pathology Atlas (2017) showing how cancer patient survival is tied to RNA and protein levels.
In addition, the group is involved and leading two additional comprehensive programs involving the human secreted proteins (The Human Secretome Project) and profiling human health and disease using integrated omics approaches (the Swedish SciLifeLab SCAPIS Wellness program – S3WP). In addition, the group is involved in development of targeted proteomics methods with a focus on plasma analysis. The group consists of approximately 20 persons and includes four team leaders responsible for various parts of the research efforts:
Kalle von Feilitzen – responsible for IT, software engineering and database handling and visualization
Linn Fagerberg – responsible for the wellness program and the integrative omics efforts
Björn Forsström – responsible for the targeted proteomics efforts
Cristina Al-Khalili Szigyarto – responsible for the work on Neuromuscular Disorders and the database Antibodypedia.
Publication list can be found at Google Scholar.