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Research group:

KTH SCHOOL OF CHEMISTRY BIOTECHNOLOGY AND HEALTH

DEPARTMENT OF PROTEIN SCIENCE

DIVISION OF PROTEIN ENGINEERING

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Principal Investigator (PI):

Prof. Per-Åke Nygren ()

 

Present group members:

Dr. Johan Nilvebrant (Researcher)
Dr. Benedetta Maria Sala (PostDoc)
M. Sc. Kim Anh Giang (Research engineer)

 

 

Description:

The research group has a present focus on the use of combinatorial protein engineering principles to provide new tools for a variety of biotechnology applications, with an emphasis on affinity biotechnology. A core technology is an in-house developed platform for the generation of tailor-made affinity proteins, denoted affibodies. These are isolated by different powerful selection principles from large collections (libraries) constructed by combinatorial mutagenesis of a small and robust protein domain used as scaffold. Such "artificial antibodies" are at present explored for use in a variety of applications, incl. bioseparation, in vivo diagnostics (imaging) and therapy. The group is also exploring different means for construction and handling of large gene/protein libraries during selections, including phage display, ribosome display and protein fragment complementation assay (PCA).

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Profilbild av Per-Åke Nygren

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