Extra material

We have a separate page with extra non-public reading material available at www.tcblab.org/outgoing/proteinphysics. You can e-mail Magnus Andersson to get the password if you are registered on the course, or ask during class. The rest of that site is currently under production...

* Lecture 1: MonTuesday Jan 20, 4-63-5pm, Room FE2A31Introduction, proteins, amino acids. Chapters 1 & 2 of the book. slidesThe review by David Eisenberg - it's a good read - and will facilitate your understanding of protein secondary structure - optional though. 2003_Review

* Lecture 2: Tuesday Jan 212, 4-61-3pm, Room FE21Molecular interactions (chapters 3-4). slidesCyrus Levinthals paper in Scientific American on protein structure & folding - good introduction - but optional for this course. Levinthal

* Lecture 3: Monday Jan 27, 3-5pm, Room FE21Thermodynamics, defining hydrophobic effect from free energies, electrostatics (chapter 5-6). slides

* Lecture 4: Thursday Jan 30, 3-529, 1-3pm, Room FB4A31Secondary structure (chapters 7,10). Note that we cover chapters 8 & 9 later! slides

* Lecture 5: Monday Feb 3, 3-5p10-12am, Room FE2A31Statistical mechanics, the partition function, phase transitions & a-helix formation (chapter 8 & 9 (to p. 109)). slides

* Lecture 6: Thursday February 6, 3-5p10-12am, Room FE2A31Protein secondary structure formation and free energy (rest of chapter 9). slides

* Lecture 7: WednesFriday February 123, 1-3p8-10am, Room FA3E21Fibrous proteins and globular proteins with alpha-helix and beta-sheet structure (chapter 11, 13 & 14). slides

* Lecture 8: Thursday February 139, 8-10a1-3pm, Room FE2D41 Membranes & membrane proteins (chapter 12, but we will deviate a lot from the book). slides

* Lecture 9: Friday February 210, 3-5p10-12am, Room FE21B54Protein folds (chapter 15-16). slides

* Lecture 10:MonTuesday February 24, 3-5p10-12am, Room FE2A31Denaturation & the character of transitions - cooperativity or not (chapter 17-18). slides

* Lecture 11:WedneThursday Feb 26, 3-51-3pm, Room FE2A31Kinetics of protein foldning (chapters 19-21). slides

* Lecture 12:Friday Feb 287, 3-51-3pm, Room FE21Prediction and design of protein structure, bioinformatics (chapters 22-23). slides

* Lecture 13:MonTuesday March 3, 3-5p10-12am, Room FE2A31GPCRs, docking and drug design (chapters 24-25, deviate a lot from the book). slides

* Lecture 14:Friday March 115, 3-5pm, Room FB5A31Course repetition. slides