Skip to main content

Advanced BioProduction by Continuous Processing

The Competence Centre for Advanced BioProduction by Continuous Processing, AdBIOPRO, aims at developing competitive technology for bioproduction, focusing on the imminent paradigm shift towards continuous processes of biopharmaceuticals, and on manufacturing of emerging potent therapeutic products such as recombinant viral vector and cell products.


  • Build up a dynamic, highly competitive, environment for research on technology for industrial bioproduction, sustainable well beyond the life-time of the Centre;

  • Profile Sweden as leader in development of continuous processes for biologics production

  • Develop AdBIOPRO into the premiere research Centre in the world in this field;

  • Provide the Swedish industry with distinct competitive advantages in this field, in terms of new technologies, knowledge, training and highly qualified personnel.

Driven by their complementary competence, academic expertise from five teams at KTH, covering mammalian cell bioprocessing (Docent Véronique Chotteau), cell omics characterization (Assistant Prof. Johan Rockberg), gene therapy (Prof. Torbjörn Gräslund), downstream processing (Prof. Sophia Hober) and data driven modelling and control (Prof. Håkan Hjalmarsson and Prof. Elling W Jacobsen), are joining forces with partners from Karolinska University Hospital (Associate Prof. Pontus Blomberg) and Lund University (Prof. Bernt Nilsson) and seven industrial partners, Swedish Orphan Biovitrum, Cobra Biologics, BioInvent, GE Healthcare Life Sciences, Valneva, Lab-on-a-Bead, and XNK Therapeutics to create a sustainable environment for this purpose. AdBIOPRO is co-funded by VINNOVA and the industrial partners.

Integrated continuous bioprocess
Biopharmaceuticals have become the best selling drugs in terms of revenues, e.g. with monoclonal antibody sales, compared to small molecules. Beyond the supremacy of monoclonal antibodies, the actual trends are going towards growing pipelines of biopharmaceuticals, more complex protein drugs but also cell-based emerging alternative therapeutic approaches such as gene and cell therapy. In the domain of biopharmaceutical manufacturing, the legacy is fed-batch process (i.e. batch process fed with time) followed by several batch purification steps, e.g. chromatography steps, supported by in house industrial technology platforms. However the field is rapidly evolving by incorporating novel technologies to meet the challenges brought by the new trends and a constant need of competitiveness.
In this perspective, continuous processes have recently received a very high interest. Integrated continuous bioprocesses consist of perfusion culture where medium is steadily added and harvest is removed to be processed in a purification process made of continuous consecutive steps. 

Why continuous bioprocess for biologics production?
This recent interest is rapidly increasing and it is clear that nearly all the large Pharma/Biotech companies are now looking into this type of intensified process. The drivers behind this new trend are several: the main one is the highly reduced need of capital expenditure due to potential high productivity in smaller bioreactors, other factors are better/more robust cell separation devices, high need of flexibility combined with increased use of disposable equipment, possibility to fine tune or control the product quality, reduced cost of resins for purification and declaration from FDA and EMA that biologics production should switch towards continuous processes. 


The AdBIOPRO competence center receives approximately SEK 37,5 million, year 1-5. 

Funding: Vinnova, and co-funding of the industrial partners 


Page responsible:Johan Sven Erik Rockberg
Belongs to: Advanced BioProduction by Continuous Processing
Last changed: Sep 01, 2020