# Peer reviewed publications

Peer reviewed publications of AdBIOPRO in journals and proceedings for period 1

- H. Schwarz
*et al.*, “Integrated continuous biomanufacturing on pilot scale for acid‐sensitive monoclonal antibodies,”*Biotechnology and bioengineering*, vol. 119, no. 8, pp. 2152–2166, 2022, doi: 10.1002/bit.28120. - K. Colin, H. Hjalmarsson, and V. Chotteau, “Gaussian process modeling of macroscopic kinetics: a better-tailored kernel for Monod-type kinetics,”
*IFAC-PapersOnLine*, vol. 55, no. 20, pp. 397–402, 2022, doi: 10.1016/j.ifacol.2022.09.127. - M. Malm
*et al.*, “Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins,”*Metabolic engineering*, vol. 72, pp. 171–187, 2022, doi: 10.1016/j.ymben.2022.03.009. - Y. Wang, M. Pasquini, V. Chotteau, H. Hjalmarsson, and E. W. Jacobsen, “Robust optimization with optimal experiment design - with application to continuous biopharmaceutical production,”
*IFAC PapersOnLine*, vol. 55, no. 7, pp. 234–241, 2022, doi: 10.1016/j.ifacol.2022.07.450. - R. Saghaleyni
*et al.*, “Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells,”*Cell reports (Cambridge)*, vol. 39, no. 11, pp. 110936–110936, 2022, doi: 10.1016/j.celrep.2022.110936. - M. M. Barzadd
*et al.*, “Autophagy and intracellular product degradation genes identified by systems biology analysis reduce aggregation of bispecific antibody in CHO cells,”*New biotechnology*, vol. 68, pp. 68–76, 2022, doi: 10.1016/j.nbt.2022.01.010. - H. Schwarz, M. E. Mäkinen, A. Castan, and V. Chotteau, “Monitoring of amino acids and antibody N-glycosylation in high cell density perfusion culture based on Raman spectroscopy,”
*Biochemical engineering journal*, vol. 182, pp. 108426-, 2022, doi: 10.1016/j.bej.2022.108426. - N. A. Brechmann
*et al.*, “Proof-of-Concept of a Novel Cell Separation Technology Using Magnetic Agarose-Based Beads,”*Magnetochemistry*, vol. 8, no. 3, pp. 34-, 2022, doi: 10.3390/magnetochemistry8030034. -
B. Ladd, K. Bowes, M. Lundgren, T. Gräslund, and V. Chotteau, “Proof-of-Concept of Continuous Transfection for Adeno-Associated Virus Production in Microcarrier-Based Culture,”

*Processes*, vol. 10, no. 3, pp. 515-, 2022, doi: 10.3390/pr10030515. -
J. Scheffel

*et al.*, “Design of an integrated continuous downstream process for acid-sensitive monoclonal antibodies based on a calcium-dependent Protein A ligand,”*Journal of Chromatography A*, vol. 1664, pp. 462806-, 2022, doi: 10.1016/j.chroma.2022.462806. -
H. Nahi

*et al.*, “Autologous NK cells as consolidation therapy following stem cell transplantation in multiple myeloma,”*Cell reports. Medicine*, vol. 3, no. 2, pp. 100508-, 2022, doi: 10.1016/j.xcrm.2022.100508. -
I. F. Pinto

*et al.*, “Knowing more from less: miniaturization of ligand-binding assays and electrophoresis as new paradigms for at-line monitoring and control of mammalian cell bioprocesses,”*Current opinion in biotechnology*, vol. 71, pp. 55–64, 2021, doi: 10.1016/j.copbio.2021.06.018. -
L. Zhang, M. Wang, A. Castan, H. Hjalmarsson, and V. Chotteau, “Probabilistic model by Bayesian network for the prediction of antibody glycosylation in perfusion and fed‐batch cell cultures,”

*Biotechnology and bioengineering*, vol. 118, no. 9, pp. 3447–3459, 2021, doi: 10.1002/bit.27769. -
S. Särnlund, Y. Jiang, and V. Chotteau, “Process intensification to produce a difficult‐to‐express therapeutic enzyme by high cell density perfusion or enhanced fed‐batch,”

*Biotechnology and bioengineering*, vol. 118, no. 9, pp. 3533–3544, 2021, doi: 10.1002/bit.27806. -
N. A. Brechmann, H. Schwarz, P. Eriksson, K. Eriksson, A. Shokri, and V. Chotteau, “Antibody capture process based on magnetic beads from very high cell density suspension,”

*Biotechnology and bioengineering*, vol. 118, no. 9, pp. 3499–3510, 2021, doi: 10.1002/bit.27776. -
D. Rodrigues, M. R. Abdalmoaty, E. W. Jacobsen, V. Chotteau, and H. Hjalmarsson, “An integrated approach for modeling and identification of perfusion bioreactors via basis flux modes,”

*Computers & chemical engineering*, vol. 149, pp. 107238-, 2021, doi: 10.1016/j.compchemeng.2021.107238. -
L. Zhang, H. Schwarz, M. Wang, A. Castan, H. Hjalmarsson, and V. Chotteau, “Control of IgG glycosylation in CHO cell perfusion cultures by GReBA mathematical model supported by a novel targeted feed, TAFE,”

*Metabolic engineering*, vol. 65, pp. 135–145, 2021, doi: 10.1016/j.ymben.2020.11.004. -
A. Löfgren, J. Gomis‐Fons, N. Andersson, B. Nilsson, L. Berghard, and C. Lagerquist Hägglund, “An integrated continuous downstream process with real‐time control: A case study with periodic countercurrent chromatography and continuous virus inactivation,”

*Biotechnology and bioengineering*, vol. 118, no. 4, pp. 1664–1676, 2021, doi: 10.1002/bit.27681. -
A.-L. Volk

*et al.*, “Bispecific Antibody Molecule Inhibits Tumor Cell Proliferation More Efficiently Than the Two-Molecule Combination,”*Drugs in R&D*, vol. 21, no. 2, pp. 157–168, 2021, doi: 10.1007/s40268-021-00339-2. -
J. Scheffel and S. Hober, “Highly selective Protein A resin allows for mild sodium chloride-mediated elution of antibodies,”

*Journal of Chromatography A*, vol. 1637, pp. 461843-, 2021, doi: 10.1016/j.chroma.2020.461843. -
J. Gomis-Fons, M. Yamanee-Nolin, N. Andersson, and B. Nilsson, “Optimal loading flow rate trajectory in monoclonal antibody capture chromatography,”

*Journal of Chromatography A*, vol. 1635, pp. 461760-, 2021, doi: 10.1016/j.chroma.2020.461760. -
M. Moreno-González, D. Keulen, J. Gomis-Fons, G. L. Gomez, B. Nilsson, and M. Ottens, “Continuous adsorption in food industry: The recovery of sinapic acid from rapeseed meal extract,”

*Separation and purification technology*, vol. 254, pp. 117403-, 2021, doi: 10.1016/j.seppur.2020.117403. -
M. Wang, E. W. Jacobsen, V. Chotteau and H. Hjalmarsson, "Estimation of Heteroscedastic Multilinear Systems" in

*2020 59th IEEE Conference on Decision and Control (CDC)*, 2020, pp. 2875-2880, doi: 10.1109/CDC42340.2020.9304127. -
M. Wang, E. W. Jacobsen, V. Chotteau and H. Hjalmarsson, "Unscented Bayes Methods for Hierarchical Gaussian Processes," in

*2020 Australian and New Zealand Control Conference (ANZCC)*, 2020, pp. 137-142, doi: 10.1109/ANZCC50923.2020.9318341. -
P. Eisenhut

*et al.*, “Systematic use of synthetic 5’-UTR RNA structures to tune protein translation improves yield and quality of complex proteins in mammalian cell factories,”*Nucleic acids research*, vol. 48, no. 20, pp. e119–e119, 2020, doi: 10.1093/nar/gkaa847. -
C. Zhan

*et al.*, “Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells,”*iScience*, vol. 23, no. 11, pp. 101653–101653, 2020, doi: 10.1016/j.isci.2020.101653. -
M. Malm

*et al.*, “Evolution from adherent to suspension: systems biology of HEK293 cell line development,”*Scientific reports*, vol. 10, no. 1, pp. 18996–18996, 2020, doi: 10.1038/s41598-020-76137-8. -
J. Gomis‐Fons

*et al.*, “Model‐based design and control of a small‐scale integrated continuous end‐to‐end mAb platform,”*Biotechnology progress*, vol. 36, no. 4, pp. e2995-n/a, 2020, doi: 10.1002/btpr.2995. -
D. Rodrigues, M. Abdalmoaty, and H. Hjalmarsson, “Toward Tractable Global Solutions to Maximum-Likelihood Estimation Problems via Sparse Sum-of-Squares Relaxations,” in

*2020 American Control Conference (ACC)*, 2020, pp. 1501-1506, doi: 10.23919/ACC45564.2020.9147484. - J. Gomis-Fons, N. Andersson, and B. Nilsson, “Optimization study on periodic counter-current chromatography integrated in a monoclonal antibody downstream process,”
*Journal of Chromatography A*, vol. 1621, pp. 461055-, 2020, doi: 10.1016/j.chroma.2020.461055. -
M. Wang, R. S. Risuleo, E. W. Jacobsen, V. Chotteau, and H. Hjalmarsson, “Identification of nonlinear kinetics of macroscopic bio-reactions using multilinear Gaussian processes,”

*Computers & chemical engineering*, vol. 133, pp. 106671-, 2020, doi: 10.1016/j.compchemeng.2019.106671. -
L. Zhang

*et al.*, “Glycan Residues Balance Analysis - GReBA: A novel model for the N-linked glycosylation of IgG produced by CHO cells,”*Metabolic engineering*, vol. 57, pp. 118–128, 2020, doi: 10.1016/j.ymben.2019.08.016. -
D. Rodrigues, M. Abdalmoaty, and H. Hjalmarsson, “Toward Tractable Global Solutions to Maximum-Likelihood Estimation Problems via Sparse Sum-of-Squares Relaxations,” in

*2019 IEEE 58th Conference on Decision and Control (CDC)*, 2019, pp. 3184-. doi: 10.1109/cdc40024.2019.9029890. -
J. Scheffel, S. Kanje, J. Borin, and S. Hober, “Optimization of a calcium-dependent Protein A-derived domain for mild antibody purification,”

*mAbs*, vol. 11, no. 8, pp. 1492–1501, 2019, doi: 10.1080/19420862.2019.1662690. -
J. Gomis-Fons, A. Löfgren, N. Andersson, B. Nilsson, L. Berghard, and S. Wood, “Integration of a complete downstream process for the automated lab-scale production of a recombinant protein,”

*Journal of biotechnology*, vol. 301, pp. 45–51, 2019, doi: 10.1016/j.jbiotec.2019.05.013. -
M. Wang, E. W. Jacobsen, V. Chotteau, and H. Hjalmarsson, “A Multi-Step Least-Squares Method for Nonlinear Rational Models,” in

*2019 American Control Conference (ACC)*, 2019, vol. 2019-, pp. 4509–4514. doi: 10.23919/ACC.2019.8814404. -
E. Hagrot, H. Æ. Oddsdóttir, M. Mäkinen, A. Forsgren, and V. Chotteau, “Novel column generation-based optimization approach for poly-pathway kinetic model applied to CHO cell culture,”

*Metabolic engineering communications*, vol. 8, pp. e00083–e00083, 2019, doi: 10.1016/j.mec.2018.e00083. -
N. A. Brechmann

*et al.*, “Pilot‐scale process for magnetic bead purification of antibodies directly from non‐clarified CHO cell culture,”*Biotechnology progress*, vol. 35, no. 3, pp. e2775-n/a, 2019, doi: 10.1002/btpr.2775. -
D. Rodrigues and H. Hjalmarsson, “Stability and performance analysis of control based on incomplete models,”

*IFAC-PapersOnLine*, vol. 52, no. 1, pp. 874–879, 2019, doi: 10.1016/j.ifacol.2019.06.172. -
L. Zhang, A. Castan, J. Stevenson, N. Chatzissavidou, F. Vilaplana, and V. Chotteau, “Combined effects of glycosylation precursors and lactate on the glycoprofile of IgG produced by CHO cells,”

*Journal of biotechnology*, vol. 289, pp. 71–79, 2019, doi: 10.1016/j.jbiotec.2018.11.004.