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Peer reviewed publications

Peer reviewed publications of AdBIOPRO in journals and proceedings for period 1

  • H. Schwarz et al., “Integrated continuous biomanufacturing on pilot scale for acid‐sensitive monoclonal antibodies,” Biotechnology and bioengineering, vol. 119, no. 8, pp. 2152–2166, 2022, doi: 10.1002/bit.28120.
  • K. Colin, H. Hjalmarsson, and V. Chotteau, “Gaussian process modeling of macroscopic kinetics: a better-tailored kernel for Monod-type kinetics,” IFAC-PapersOnLine, vol. 55, no. 20, pp. 397–402, 2022, doi: 10.1016/j.ifacol.2022.09.127.
  • M. Malm et al., “Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins,” Metabolic engineering, vol. 72, pp. 171–187, 2022, doi: 10.1016/j.ymben.2022.03.009.
  • Y. Wang, M. Pasquini, V. Chotteau, H. Hjalmarsson, and E. W. Jacobsen, “Robust optimization with optimal experiment design - with application to continuous biopharmaceutical production,” IFAC PapersOnLine, vol. 55, no. 7, pp. 234–241, 2022, doi: 10.1016/j.ifacol.2022.07.450.
  • R. Saghaleyni et al., “Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells,” Cell reports (Cambridge), vol. 39, no. 11, pp. 110936–110936, 2022, doi: 10.1016/j.celrep.2022.110936.
  • M. M. Barzadd et al., “Autophagy and intracellular product degradation genes identified by systems biology analysis reduce aggregation of bispecific antibody in CHO cells,” New biotechnology, vol. 68, pp. 68–76, 2022, doi: 10.1016/j.nbt.2022.01.010.
  • H. Schwarz, M. E. Mäkinen, A. Castan, and V. Chotteau, “Monitoring of amino acids and antibody N-glycosylation in high cell density perfusion culture based on Raman spectroscopy,” Biochemical engineering journal, vol. 182, pp. 108426-, 2022, doi: 10.1016/j.bej.2022.108426.
  • N. A. Brechmann et al., “Proof-of-Concept of a Novel Cell Separation Technology Using Magnetic Agarose-Based Beads,” Magnetochemistry, vol. 8, no. 3, pp. 34-, 2022, doi: 10.3390/magnetochemistry8030034.

  • B. Ladd, K. Bowes, M. Lundgren, T. Gräslund, and V. Chotteau, “Proof-of-Concept of Continuous Transfection for Adeno-Associated Virus Production in Microcarrier-Based Culture,” Processes, vol. 10, no. 3, pp. 515-, 2022, doi: 10.3390/pr10030515.

  • J. Scheffel et al., “Design of an integrated continuous downstream process for acid-sensitive monoclonal antibodies based on a calcium-dependent Protein A ligand,” Journal of Chromatography A, vol. 1664, pp. 462806-, 2022, doi: 10.1016/j.chroma.2022.462806.

  • H. Nahi et al., “Autologous NK cells as consolidation therapy following stem cell transplantation in multiple myeloma,” Cell reports. Medicine, vol. 3, no. 2, pp. 100508-, 2022, doi: 10.1016/j.xcrm.2022.100508.

  • I. F. Pinto et al., “Knowing more from less: miniaturization of ligand-binding assays and electrophoresis as new paradigms for at-line monitoring and control of mammalian cell bioprocesses,” Current opinion in biotechnology, vol. 71, pp. 55–64, 2021, doi: 10.1016/j.copbio.2021.06.018.

  • L. Zhang, M. Wang, A. Castan, H. Hjalmarsson, and V. Chotteau, “Probabilistic model by Bayesian network for the prediction of antibody glycosylation in perfusion and fed‐batch cell cultures,” Biotechnology and bioengineering, vol. 118, no. 9, pp. 3447–3459, 2021, doi: 10.1002/bit.27769.

  • S. Särnlund, Y. Jiang, and V. Chotteau, “Process intensification to produce a difficult‐to‐express therapeutic enzyme by high cell density perfusion or enhanced fed‐batch,” Biotechnology and bioengineering, vol. 118, no. 9, pp. 3533–3544, 2021, doi: 10.1002/bit.27806.

  • N. A. Brechmann, H. Schwarz, P. Eriksson, K. Eriksson, A. Shokri, and V. Chotteau, “Antibody capture process based on magnetic beads from very high cell density suspension,” Biotechnology and bioengineering, vol. 118, no. 9, pp. 3499–3510, 2021, doi: 10.1002/bit.27776.

  • D. Rodrigues, M. R. Abdalmoaty, E. W. Jacobsen, V. Chotteau, and H. Hjalmarsson, “An integrated approach for modeling and identification of perfusion bioreactors via basis flux modes,” Computers & chemical engineering, vol. 149, pp. 107238-, 2021, doi: 10.1016/j.compchemeng.2021.107238.

  • L. Zhang, H. Schwarz, M. Wang, A. Castan, H. Hjalmarsson, and V. Chotteau, “Control of IgG glycosylation in CHO cell perfusion cultures by GReBA mathematical model supported by a novel targeted feed, TAFE,” Metabolic engineering, vol. 65, pp. 135–145, 2021, doi: 10.1016/j.ymben.2020.11.004.

  • A. Löfgren, J. Gomis‐Fons, N. Andersson, B. Nilsson, L. Berghard, and C. Lagerquist Hägglund, “An integrated continuous downstream process with real‐time control: A case study with periodic countercurrent chromatography and continuous virus inactivation,” Biotechnology and bioengineering, vol. 118, no. 4, pp. 1664–1676, 2021, doi: 10.1002/bit.27681.

  • A.-L. Volk et al., “Bispecific Antibody Molecule Inhibits Tumor Cell Proliferation More Efficiently Than the Two-Molecule Combination,” Drugs in R&D, vol. 21, no. 2, pp. 157–168, 2021, doi: 10.1007/s40268-021-00339-2.

  • J. Scheffel and S. Hober, “Highly selective Protein A resin allows for mild sodium chloride-mediated elution of antibodies,” Journal of Chromatography A, vol. 1637, pp. 461843-, 2021, doi: 10.1016/j.chroma.2020.461843.

  • J. Gomis-Fons, M. Yamanee-Nolin, N. Andersson, and B. Nilsson, “Optimal loading flow rate trajectory in monoclonal antibody capture chromatography,” Journal of Chromatography A, vol. 1635, pp. 461760-, 2021, doi: 10.1016/j.chroma.2020.461760.

  • M. Moreno-González, D. Keulen, J. Gomis-Fons, G. L. Gomez, B. Nilsson, and M. Ottens, “Continuous adsorption in food industry: The recovery of sinapic acid from rapeseed meal extract,” Separation and purification technology, vol. 254, pp. 117403-, 2021, doi: 10.1016/j.seppur.2020.117403.

  • M. Wang, E. W. Jacobsen, V. Chotteau and H. Hjalmarsson, "Estimation of Heteroscedastic Multilinear Systems" in 2020 59th IEEE Conference on Decision and Control (CDC), 2020, pp. 2875-2880, doi: 10.1109/CDC42340.2020.9304127.

  • M. Wang, E. W. Jacobsen, V. Chotteau and H. Hjalmarsson, "Unscented Bayes Methods for Hierarchical Gaussian Processes," in 2020 Australian and New Zealand Control Conference (ANZCC), 2020, pp. 137-142, doi: 10.1109/ANZCC50923.2020.9318341.

  • P. Eisenhut et al., “Systematic use of synthetic 5’-UTR RNA structures to tune protein translation improves yield and quality of complex proteins in mammalian cell factories,” Nucleic acids research, vol. 48, no. 20, pp. e119–e119, 2020, doi: 10.1093/nar/gkaa847.

  • C. Zhan et al., “Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells,” iScience, vol. 23, no. 11, pp. 101653–101653, 2020, doi: 10.1016/j.isci.2020.101653.

  • M. Malm et al., “Evolution from adherent to suspension: systems biology of HEK293 cell line development,” Scientific reports, vol. 10, no. 1, pp. 18996–18996, 2020, doi: 10.1038/s41598-020-76137-8.

  • J. Gomis‐Fons et al., “Model‐based design and control of a small‐scale integrated continuous end‐to‐end mAb platform,” Biotechnology progress, vol. 36, no. 4, pp. e2995-n/a, 2020, doi: 10.1002/btpr.2995.

  • D. Rodrigues, M. Abdalmoaty, and H. Hjalmarsson, “Toward Tractable Global Solutions to Maximum-Likelihood Estimation Problems via Sparse Sum-of-Squares Relaxations,” in 2020 American Control Conference (ACC), 2020, pp. 1501-1506, doi: 10.23919/ACC45564.2020.9147484.

  • J. Gomis-Fons, N. Andersson, and B. Nilsson, “Optimization study on periodic counter-current chromatography integrated in a monoclonal antibody downstream process,” Journal of Chromatography A, vol. 1621, pp. 461055-, 2020, doi: 10.1016/j.chroma.2020.461055.

  • M. Wang, R. S. Risuleo, E. W. Jacobsen, V. Chotteau, and H. Hjalmarsson, “Identification of nonlinear kinetics of macroscopic bio-reactions using multilinear Gaussian processes,” Computers & chemical engineering, vol. 133, pp. 106671-, 2020, doi: 10.1016/j.compchemeng.2019.106671.

  • L. Zhang et al., “Glycan Residues Balance Analysis - GReBA: A novel model for the N-linked glycosylation of IgG produced by CHO cells,” Metabolic engineering, vol. 57, pp. 118–128, 2020, doi: 10.1016/j.ymben.2019.08.016.

  • D. Rodrigues, M. Abdalmoaty, and H. Hjalmarsson, “Toward Tractable Global Solutions to Maximum-Likelihood Estimation Problems via Sparse Sum-of-Squares Relaxations,” in 2019 IEEE 58th Conference on Decision and Control (CDC), 2019, pp. 3184-. doi: 10.1109/cdc40024.2019.9029890.

  • J. Scheffel, S. Kanje, J. Borin, and S. Hober, “Optimization of a calcium-dependent Protein A-derived domain for mild antibody purification,” mAbs, vol. 11, no. 8, pp. 1492–1501, 2019, doi: 10.1080/19420862.2019.1662690.

  • J. Gomis-Fons, A. Löfgren, N. Andersson, B. Nilsson, L. Berghard, and S. Wood, “Integration of a complete downstream process for the automated lab-scale production of a recombinant protein,” Journal of biotechnology, vol. 301, pp. 45–51, 2019, doi: 10.1016/j.jbiotec.2019.05.013.

  • M. Wang, E. W. Jacobsen, V. Chotteau, and H. Hjalmarsson, “A Multi-Step Least-Squares Method for Nonlinear Rational Models,” in 2019 American Control Conference (ACC), 2019, vol. 2019-, pp. 4509–4514. doi: 10.23919/ACC.2019.8814404.

  • E. Hagrot, H. Æ. Oddsdóttir, M. Mäkinen, A. Forsgren, and V. Chotteau, “Novel column generation-based optimization approach for poly-pathway kinetic model applied to CHO cell culture,” Metabolic engineering communications, vol. 8, pp. e00083–e00083, 2019, doi: 10.1016/j.mec.2018.e00083.

  • N. A. Brechmann et al., “Pilot‐scale process for magnetic bead purification of antibodies directly from non‐clarified CHO cell culture,” Biotechnology progress, vol. 35, no. 3, pp. e2775-n/a, 2019, doi: 10.1002/btpr.2775.

  • D. Rodrigues and H. Hjalmarsson, “Stability and performance analysis of control based on incomplete models,” IFAC-PapersOnLine, vol. 52, no. 1, pp. 874–879, 2019, doi: 10.1016/j.ifacol.2019.06.172.

  • L. Zhang, A. Castan, J. Stevenson, N. Chatzissavidou, F. Vilaplana, and V. Chotteau, “Combined effects of glycosylation precursors and lactate on the glycoprofile of IgG produced by CHO cells,” Journal of biotechnology, vol. 289, pp. 71–79, 2019, doi: 10.1016/j.jbiotec.2018.11.004.