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John Löfblom

Profile picture of John Löfblom

PROFESSOR

Researcher

Researcher ID

About me

I am Professor at the Department of Protein Science, CBH school. The general focus of my group´s research activities is on protein engineering technology and development of methods for directed evolution.

The principle of directed evolution is based on more or less random mutagenesis of the gene encoding the protein of interest for construction of large collections of variants, so-called combinatorial libraries. The libraries are then used in selections or high-throughput screenings for isolation of new engineered proteins with tailor-made properties.

Current research is including:

  • engineering of artificial ligands for targeting angiogenesis and tissue engineering
  • engineering of prodrug formats of affinity proteins and cell therapies 
  • development of methods for directed evolution of protease and protease substrates
  • engineering of targeting agents for improved uptake into the central nervous system
  • engineering of tracers for molecular imaging of cancer
  • development of high-throughput screening methods for affinity proteins

Learn more about our research under “Portfolio” to the right.

We are always looking for talented students and if you are interested in doing a Master's Thesis project in the group, please contact me at lofblom@kth.se.

I am also engaged in teaching activities and course responsible for Analysis of Biomolecules (Year 2) as well as giving guest lectures in protein technology and combinatorial protein engineering.

For a publication list see my Google Scholar profile.


Courses

Analysis of Biomolecules (BB1200), examiner, course responsible | Course web

Degree Project in Biotechnology, First Cycle (BB103X), teacher | Course web

Higher Seminar in Protein Science I (FCB3021), examiner, course responsible, teacher | Course web

Higher Seminar in Protein Science II (FCB3022), examiner, course responsible, teacher | Course web

Higher Seminar in Protein Science III (FCB3023), examiner, course responsible, teacher | Course web

Higher Seminar in Protein Science IV (FCB3024), examiner, course responsible, teacher | Course web

Methods in Current Research in Medical Biotechnology (FCB3201), examiner | Course web