Peter Nilsson

Affiliation:

• Div of Affinity Proteomics
• Dept of Protein Science, CBH
• SciLifeLab
• KTH Royal Institute of Technology

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• 1998      PhD in Biotechnology, KTH
• 2011      Professor in Proteomics, KTH
• Vice Head of Division of Biomedical Proteomics
• Platform Scientific Director in the SciLifeLab national infrastructure Proteomics platform, representing Affinity Proteomics Stockholm unit

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Multiplex protein and antibody profiling within infectious diseases, autoimmune proteomics and neuroproteomics

The research is devoted to highly multiplex protein and antibody profiling in body fluids based on various aspects of affinity proteomics. This is mainly enabled through the development and utilization of different types of protein array formats using proteins and antibodies from the Human Protein Atlas.

During the early phase of the pandemic, we rapidly developed a highly specific and sensitive high-throughput multiplex bead-based serological assay for SARS-CoV-2 that has been used to analyse over 260,000 samples. We are now extending the assay to provide a platform for multi-disease serology including a wide range of antigens representing various respiratory and infectious diseases.

Combinations of highly multiplex protein, autoantibody and serology profiling in association to studies of infectious diseases and vaccinations are now being emphasized within several international collaborations. This is currently done with a focus on mosquito spread diseases, such as dengue, zika, west nile fever, yellow fever, japanese encephalitis, mayaro, oropouche, chikungunya, and malaria.

Group members

Infectious diseases
Sofia Bergström, researcher
Priscilla Gomes da Silva, postdoc
Patricia Sosa Acosta, postdoc
Anna Gardell, PhD-student
Lovisa Skoglund, research engineer

for neuroproteomics see Anna Månberg lab

Multiplex protein and antibody profiling with a focus on amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Alzheimer’s disease, Parkinson’s disease and psychiatric disorders

for autoimmune proteomics see Elisa Pin lab

Multiplex protein and antibody profiling with a focus on vasculitis, systemic sclerosis, myositis, sarcoidosis and fibrosis

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Dissertations in the group

Sara Mravinacova	2024	Multiplexed protein analysis in neurodegenerative diseases
August Falk Jernbom	2023	On the analysis of antibody repertoires
Shaghayegh Bayati	2023	Autoantibody profiling in autoimmune diseases
Sofia Bergström	2021	Multiplexed antibody-based protein profiling in the pursuit of CSF biomarkers for neurodegenerative diseases
Tea Dodig-Crnković	2020	On the application and validation of multiplexed affinity assays
Julia Remnestål	2020	Dementia Proteomics
David Just	2019	On the profiling of autoantibodies in psychiatric disorders
Maria Mikus	2018	Array-based identification of disease-associated proteins
Philippa Reuterswärd	2018	Development of array systems for molecular diagnostic assays
Kimi Drobin	2018	Antibody-based bead arrays for high-throughput protein profiling in human plasma and serum
Arash Zandian	2017	Array-based Autoantibody Profiling and Epitope Mapping
Sanna Byström	2017	Affinity assays for profiling disease-associated proteins in human plasma
Ronald Sjöberg	2015	On Generation and Applications of High-Density Protein Microarrays
Anna Månberg	2015	Neuroproteomic profiling of human body fluids
Burcu Ayoglu	2014	Affinity Arrays for Profiling Proteins and Autoantibody Repertoires
Ulrika Qundos	2013	Antibody based plasma protein profiling
Maja Neiman	2013	Bead based protein profiling in blood
Mårten Sundberg	2011	Protein microarrays for validation of affinity binders
Ulf Ribacke	2009	Parasite virulence and disease severity in Plasmodium falciparum malaria
Marcus Gry	2008	Global expression analysis of human cells and tissues using antibodies
Johan Lindberg	2008	Transcriptional patterns in inflammatory disease
Cecilia Laurell	2006	Microarray Based Gene Expression Analysis in Cancer Research
Anders Andersson	2005	Microarray-based investigation of genome and transcriptome organisation in the archaeon sulfolobus
David Velazques-Fernandez	2005	Differential RNA expression in benign and malignant adrenocortical tumours
Hanna Gräns	2005	Transcriptome analysis of patients with chronic fatigue syndrom