Mathias Uhlén

Dr. Mathias Uhlén, Professor of Microbiology.

Mathias Uhlén

KTH Biotechnology
AlbaNova University Center
Royal Institute of Technology (KTH)
106 91 Stockholm, Sweden

Direct phone: +46 8 5537 8325
Secr: +46 8 5537 8403
Fax: +46 8 5537 8482

Contribution to science (pdf 30 kB)


Short biography

Dr Uhlen received his PhD in chemistry at the Royal Institute of Technology (KTH), Stockholm, Sweden in 1984.  After a post-doc period at the EMBL in Heidelberg, Germany, he became professor in microbiology at KTH in 1988. His research is focused on protein science, antibody engineering and molecular medicine and has resulted in more than 550 publications with an h-index of 96 (Google Scholar).

The research range from basic research in human and microbial biology to more applied research, including clinical applications in cancer, infectious diseases, cardiovascular diseases, autoimmune diseases and neurobiology.   Early in his career, he developed engineered protein A for purification of antibodies and methods based on his innovations (including MabSelectSuRe) is now used for manufacturing of most therapeutic antibodies in the clinic today. He also pioneered the use of affinity tags, such as His-tags, for purification of fusion proteins and streptavidin solid phase techniques for DNA capture, two methods now widely used in life science. His group also described a new strategy for DNA analysis called Pyrosequencing, a method that was further developed to generate the first next generation sequencing instrument (454). A new affinity reagent called Affibodies was also developed and this has led to numerous papers and several molecules in clinical trials. Since 2003, he has led an international effort to systematically map the human proteome with antibodies and to create an open source knowledge-based resource called the Human Protein Atlas  (

Dr Uhlen is member of the Royal Swedish Academy of Engineering Science (IVA), the Royal Swedish Academy of Science (KVA), the National Academy of Engineering (NAE) in USA and the European Molecular Biology Organization (EMBO). He is the President of the European Federation of Biotechnology (EFB) and he was Vice-President of the Royal Institute of Technology (KTH) from 1999 to 2001. From 2010 to 2015, he was the first Director of a new center in Stockholm and Uppsala called Science for Life Laboratory for molecular bioscience  ( He has received numerous awards, including the Göran Gustavsson prize, the Gold Medal of the Royal Swedish Academy of Engineering Sciences, the Akzo Noble Award, the HUPO Distinguished Award, the KTH Great Prize, the ABRF award, the Scheele prize and H.M. the King’s Medal with the ribbon of the Order of Seraphim.

Research: High-throughput Proteomics and Functional Genomics

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