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THERACAGE - Polymeric cell encapsulation for localized tumour treatment

Inoperable malignant tumours are treated with radiation and systemic chemotherapy, both treatments leading to a high prevalence of co-morbidity. Our aim is to enable localised chemotherapy to allow for a higher toxic drug concentration at the tumour site, while excusing the rest of the body from toxicity.

For this purpose, we develop precisely controlled polymer encapsulation of therapeutic cells prior to their implantation into a tumour. The therapeutic cells are genetically modified to convert a mild systemic drug into a high toxic compound that acts locally at the implantation site.

The cell capsules are fabricated using a droplet microfluidic system built in an OSTE+ microfluidic chip. We developed a novel polymerization scheme to produce microscale cell capsules with a well-controlled core-shell structure of diameter 100 mm. The whole working flow of this project is shown below:


  • Swedish Childhood Cancer Foundation
  • KTH Royal Institute of Technology 
  • Stockholm County Council


  • Karolinska University Hospital
  • Karolinska Institutet.

Project members

The following organisations are members of the project: 


Karolinska University Hospital

  • Matthias Löhr
  • John-Inge Jonson

Karolinska Institutet

  • Rainer Heuchel

Publications related to this project

Page responsible:Web editors at EECS
Belongs to: Micro and Nanosystems
Last changed: Dec 12, 2018