Skip to main content

Christofer Lendel

Profile picture of Christofer Lendel

ASSOCIATE PROFESSOR

Details

Telephone
Address
TEKNIKRINGEN 30

Researcher


About me

Latest news

We have taken the flow-assisted assembly of fibers from milk proteins one step further. In our recent study we use a sustainable and non-toxic crosslinker to achieve  improved mechanical properties of microfibers assembled from whey protein nanofibrils. The approach allows us to disconnect the fibril morphologies and the inter-fibril interactions in the flow-assisted assembly process and reveal important components of the structure-function relationship. We find that variations in fibril nanostructure have more noticeable effects on the structural and mechanical properties of the final fiber than previously expected. The study was just published in ACS Nano.

TOC ACS Nano 2020

Research Interests

The assembly of protein molecules into nanoscale aggregates and amyloid fibrils are key events in many biochemical processes ranging from neurodegenerative disorders, such as Alzheimer’s disease, to the design of novel nanomaterials. In my research I investigate the structural properties and interactions of such protein aggregates. In particular, I am interested in the molecular mechanisms for how protein nanostructures interact with other (bio)molecules.

 

New materials from protein nanofibrils

Protein nanofibrils display extraordinary mechanical and functional properties and has the potential to be used as building blocks for new materials with hieracrical structures. We develop methods to produce fibrils from protein-rich and renewable sources (e.g. plant proteins) and the technology to produce new protein-based materials.

 

Pathological mechanisms of protein aggregates

Protein self-assembly and deposition are hallmarks of many serious diseases but the disease-causing mechanisms remain enigmatic.  However, any pathological mechanism must involve interactions between the protein aggregates and other biomolecules. We explore and characterize such interactions in order to better understand what makes a protein nanostructure toxic.

Interactions.png

Inhibitors of protein aggregation

The mechanisms of action for small molecule inhibitors of protein aggregation remain poorly understood and the development of new therapeutics against amyloid diseases is slow. Interfering with protein self-assembly is complicated and essentially different from traditional drug design. By studying the binding mechanisms of small molecules to aggregation-prone proteins we believe that we will better understand what type of molecules could be explored as drug candidates for amyloid-diseases.

Small_molecule.png

Group members

Danilo Kimio Hirabae de Oliviera (PhD student, joint with My Hedhammar)
Rodrigo Sanches Pires (PhD student)

Selected publications

Protein nanofibrils and their use as building blocks of sustainable materials (review). Lendel & Solin RSC Adv. (2021).

Extracellular protein components of amyloid plaques and their roles in Alzheimer’s disease pathology (review). Rahman & Lendel Mol. Neurodegen. (2021).

High-temperature and chemically resistant foams from sustainable nanostructured protein. Ye et al. Adv. Sustainable Syst. (2021).

Dissecting the structural organization of multiprotein amyloid aggregates using a bottom-up approach. Chaudhary et al. ACS Chem. Neurosci. (2020).

Flow-assisted assembly of nanostructured protein microfibers. Kamada et al.Proc. Natl. Acad. Sci. USA (2017).

Binding of human proteins to amyloid-β protofibrils. Rahman et al. ACS Chem. Biol. (2015).

A hexameric peptide barrel as building block of amyloid-β protofibrils. Lendel et al. Angew. Chem. Int. Ed (2014).

Inhibition of amyloid formation (review). Härd & Lendel J. Mol. Biol. (2012).

 


Courses

Analysis of Biomolecules (BB1200), teacher | Course web

Biopolymers (KF2180), course responsible | Course web

Degree Project in Chemistry, Second Cycle (KD200X), examiner | Course web

Degree Project in Engineering Chemistry, First Cycle (KA103X), assistant | Course web

Degree Project in Technology and Learning, Second Cycle (LT200X), teacher | Course web

Introductory Chemistry (KD1020), teacher | Course web

Molecular Structure (KD1070), examiner, teacher | Course web

Perspectives on Research and Innovation (KA1030), teacher | Course web

Project in Chemistry (KD2905), examiner | Course web

Project in Chemistry (KD2910), examiner | Course web

Thermodynamics (KE1160), course responsible | Course web