Mathias Uhlén

Dr. Mathias Uhlén, Professor of Microbiology.

Mathias Uhlén

KTH Biotechnology
AlbaNova University Center
Royal Institute of Technology (KTH)
106 91 Stockholm, Sweden

Email: mathias@biotech.kth.se
Direct phone: +46 8 790 99 93
Secr: +46 8 790 99 87

CV (docx 536 kB)



 



 

Short biography

Mathias Uhlen received his PhD at the Royal Institute of Technology (KTH), Stockholm, Sweden in 1984. After a post-doc period at the EMBL in Heidelberg, Germany, he became professor in microbiology at KTH in 1988. His research is focused on protein science, antibody engineering and precision medicine and range from basic research in human and microbial biology to more applied research, including clinical applications in cancer, infectious diseases, cardiovascular diseases, autoimmune diseases and neurobiology. His research has resulted in more than 600 publications. His group was the first to describe a number of innovations in science including:

Since 2003, he has led an international effort to systematically map the human proteome and transcriptome to create a Human Protein Atlas7 using antibodies8 and various omics technologies. This effort has so far resulted in three major launches:

  • The Tissue Atlas9 showing the distribution of proteins across human tissues and organs
  • The Cell Atlas10 showing the subcellular location of human proteins in single cells
  • The Pathology Atlas11 showing how cancer patient survival is tied to RNA and protein levels

He is member of the National Academy of Engineering (NAE) in USA, the Royal Swedish Academy of Science (KVA), the Swedish Academy of Engineering Science (IVA) and the European Molecular Biology Organization (EMBO). He is the President of the European Federation of Biotechnology. From 2010-2015, he was the founding Director of the Science for Life Laboratory (SciLifeLab)  which is a national center for molecular bioscience.

Career

1979 M.Sc. in Chemical Engineering, KTH, Stockholm, Sweden.
1984 Ph.D. Dept. of Biotechnology, KTH, Stockholm, Sweden
1985-86 Post-doc, EMBL, Heidelberg, Germany
1988- Full professor in Biotechnology, KTH, Stockholm, Sweden
1999-2001 Vice-President KTH, responsible for external relations
2003- Director of the Human Protein Atlas (HPA) program
2012- Professor (20%), Danish Technical University (DTU), Denmark
2010-2015 Founding Director, Science for Life Laboratory (SciLifeLab)

Recognition

Key references

  1. Uhlen et al (1984) J Biol Chem 259: 1695-702
  2. Guss et al (1988) EMBO J 5: 1567-75
  3. Nilsson, Abrahmsen and Uhlen (1985) EMBO J 4: 1075-80
  4. Uhlen (1989) Nature 340: 733-4
  5. Ronaghi, Uhlen and Nyren (1998) Science 281: 363-5
  6. Nord et al (1997) Nature Biotechnology 15: 772-7
  7. Uhlen et al (2010) Nature Biotechnology 28: 1248-50
  8. Uhlen et al (2016) Nature Methods, 13: 823-7
  9. Uhlen et al (2015) Science 347: 1260419
  10. Thul et al (2017) Science 356 (6340): eaal3321
  11. Uhlen et al (2017) Science 357 (6352): eaan2507

Scientific summary (pdf 124 kB)

Research: High-throughput Proteomics and Functional Genomics

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