Publications

Full length papers

2016:

Koeck PJB (2016): Annular Dark Field Transmission Electron Microscopy for Protein Structure Determination, Ultramicroscopy 161, 98–104.

2015:

Koeck PJB (2015): Improved Hilbert phase contrast for transmission electron microscopy. Ultramicroscopy, 154: 37-41.

Kuang Q, Purhonen P, Jegerschöld C, Koeck PJB, Hebert H (2015): Free RCK arrangement in Kch, a putative escherichia coli potassium channel, as suggested by electron crystallography. Structure, 126(1): 199-205.

Kuang Q, Purhonen P, Pattipaka T, Ayele YH, Hebert H, Koeck PJB (2015): A Refined Single-Particle Reconstruction Procedure to Process Two-Dimensional Crystal Images from Transmission Electron Microscopy. Microscopy and Microanalysis. 21, 4, 876-885.

Koeck PJB (2015): Improved Zernike-type Phase Contrast for Transmission Electron Microscopy. Journal of Microscopy. 259, 1, 74–78.

Koeck PJB, Karshikoff A (2015): Limitations of the linear and the projection approximations in three-dimensional transmission electron microscopy of fully hydrated proteins. J Microsc. 259, 3, 197-209.

Härmark J, Larsson MK, Razuvajev A, Koeck PJB, Paradossi G, Brodin LÅ, Caidahl K, Hebert H, Bjällmark A (2015): Investigation of the elimination process of a multimodal polymer-shelled contrast agent in rats using ultrasound and transmission electron microscopy. Biomedical Spectroscopy and Imaging, 4 (1): 81-93.

2014:

Nilsson HE, Ambort D, Bäckström M, Thomsson E, Koeck PJB, Hansson GC, Hebert H (2014): Intestinal MUC2 mucin supramolecular topology by packing and release resting on D3 domain assembly. J Mol Biol. 426(14): 2567-79.

2012:

Ambort D, Johansson ME, Gustafsson JK, Nilsson HE, Ermund A, Johansson BR, Koeck PJB, Hebert H, Hansson GC (2012): “Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin”, Proc Natl Acad Sci U S A, vol. 109, p. 5645-50.

2011:

W. Lambert, P. J. B. Koeck, E. Ahrman, P. Purhonen, K. Cheng, D. Elmlund, H. Hebert and C. Emanuelsson (2011): “Subunit arrangement in the dodecameric chloroplast small heat shock protein Hsp21 “; Protein Science 20, 2, 291-301.

2010:

S.-R. Wu, R. Löving, B. Lindqvist, H. Hebert, P.J.B. Koeck, M. Sjöberg and H. Garoff (2010): ”Single particle cryo-electron microscopy analysis reveals the HIV-1 spike as a tripod structure”; PNAS 107, 44, 18844-18849.

2008:

S.-R. Wu, M. Sjöberg, M. Wallin, B. Lindqvist, H. Hebert, P.J.B. Koeck and H. Garoff (2008): ”Turning of the receptor-binding domains opens up the murine leukaemia virus Env for membrane fusion”; EMBO Journal 27, 2799-2808.

2007:

Philip J. B. Koeck, Pasi Purhonen, Ronny Alvang, Björn Grundberg and Hans Hebert (2007): “Single Particle Refinement in Electron Crystallography, a Pilot Study”; JSB 160, 3, 344-352.

2006:

K. Cheng, P. J. B. Koeck, H. Elmlund, K. Idakieva, K. Parvanova, H. Schwarz, T. Ternström and H. Hebert (2006): ” Rapana thomasiana hemocyanin (RtH): Comparison of the two isoforms, RtH1 and RtH2, at 19 Å and 16 Å resolution”; Micron 37, 6, 566-576.

H. Elmlund, V. Baraznenok, M. Lindahl, C. O. Samuelsen, P. J. B. Koeck, S. Holmberg, H. Hebert and C. M. Gustafsson (2006): “The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II”; Proc Natl Acad Sci USA 103, 43, 15788-15793.

2004:

P. J. B. Koeck (2004): “Missing Data in Image and Signal Processing: The case of binary objects”; Optik 115, 10, 459 - 472.

2001:

P. J. B. Koeck (2001): “Quantization Errors in Averaged Digitized Data”; Signal Processing 81, 345-356.

2000:

J. Hesse, H. Hebert, P.J.B. Koeck (2000): “Evaluation of Scanners and Comparison to CCD Cameras for High-Resolution TEM of Protein Crystals and Single Particles”; Microscopy Research and Technique 49, 3, 292-300.

P. J. B. Koeck (2000): “Ins and Outs of Digital Electron Microscopy”; Microscopy Research and Technique 49, 3, 217-223.

1998:

M. J. Ellis, S. Knapp, P. J. B. Koeck, Z. Fakoor-Biniaz, R. Ladenstein, H. Hebert (1998): “Two-Dimensional Crystallization of the Chaperonin TF55 from the Hyperthermophilic Archaeon Sulfolobus solfactaricus”; Journal of Structural Biology 123, 30-36.

P. J. B. Koeck, H. K. Kagawa, M. J. Ellis, H. Hebert, J. D. Trent (1998): “Two-Dimensional Crystals of Reconstituted beta-Subunits of the Chaperonin TF55 from Sulfolobus shibatae”; Biochimica et Biophysica Acta 1429, 40-44.

1996:

P. J. B. Koeck, R. R. Schröder, K. R. Leonard, M. Haider (1996): "Unconventional Immuno Double Labelling by Energy Filtered Transmission Electron Microscopy"; Ultramicroscopy 62, 65-78.

P. J. B. Koeck, K. R. Leonard (1996): "Review: Improved Immuno Double Labelling for Cell and Structural Biology"; Micron 27, 157-165.

Abstracts

2013:

Nilsson HE, Ambort D, Bäckström M, Thomsson E, Koeck PJ, Johansson MEV, Hansson GC, Hebert H (2013): “Highly organized supramolecular topology of intestinal MUC2 mucin during packing and release as revealed by structural characterization of its N-terminal D3 domain using electron microscopy” 12th International Workshop on Carcinoma-associated Mucins, Cambridge, England, 2013

Ambort D, Nilsson HE, Thomsson E, Koeck PJ, Hebert H, Bäckström M, Hansson GC (2013): “The third von Willebrand factor D domain (D3) of intestinal MUC2 mucin forms disulfide bonded trimers and non-covalent hexamers, as revealed by electron microscopy-based structural determination of the domain produced in CHO Lec3.2.8.1 cells” 17th annual conference of the Swedish Structural Biology Nework, SBnet, Tällberg, Sweden, 2013

H. E. Nilsson, D. Ambort, P.J.B. Koeck, G.C. Hansson, H. Hebert (2013): “Assembly of MUC2 N-terminal with Relevance for Mucus Formation” Scandem 2013, Annual Meeting of the Nordic Microscopy Society, Copenhagen, Denmark, 10. – 14.6.2013

J. Härmark, P.J.B. Koeck, H. Hebert (2013): “Structural Characterization of Multifunctional Microbubbles by TEM” Scandem 2013, Annual Meeting of the Nordic Microscopy Society, Copenhagen, Denmark, 10. – 14.6.2013

P.J.B. Koeck, V. P. Dandey, H. Rullgard, A. Karshikoff (2013): ”Thickness Limits for the Linear and Projection Approximations in Transmission Electron Microscopy of Fully Hydrated Proteins” Scandem 2013, Annual Meeting of the Nordic Microscopy Society, Copenhagen, Denmark, 10. – 14.6.2013

2012:

H.E. Nilsson, D. Ambort, P.J.B. Koeck, J.K. Gustafsson, G.C. Hansson, H. Hebert (2012): “ Molecular structure, packing and release of MUC2 with relevance to Cystic Fibrosis”, EMC 2012, 15th European Microscopy Congress, Manchester, England 2012

H.E. Nilsson, D. Ambort, P.J.B. Koeck, J.K. Gustafsson, G.C. Hansson, H. Hebert (2012): “Molecular structure, packing and release of MUC2 with relevance to Cystic Fibrosis” 16th annual conference of the Swedish Structural Biology Nework, SBnet, Tällberg, Sweden, 2012

2011:

Nilsson HE, Ambort D, Koeck PJ, Hansson GC, Hebert H (2011): “Molecular structure, packing and release of MUC2 with relevance to Cystic Fibrosis” invited talk at the Academic Hospital, Uppsala, Sweden

2008:

Philip J. B. Koeck, Pasi Purhonen, Ronny Alvang, Björn Grundberg and Hans Hebert (2008): “3D-correlation averaging of melibiose permease crystals”, Network of Excellence-3DEM 4th Annual Meeting, Marbach, Germany, 28.-30.1.2008

Philip J. B. Koeck, Pasi Purhonen, Ronny Alvang, Björn Grundberg and Hans Hebert (2008): “3D-correlation-averaging for membrane-protein-crystals”, EMC 2008, 14th European Microscopy Congress, Aachen, Germany, 1. – 5.9.2008

2007:

Philip J. B. Koeck, Pasi Purhonen, Björn Grundberg and Hans Hebert (2007): “Single-particle refinement of NaK-ATPase from images of two-dimensional crystals”, Network of Excellence-3DEM 3rd Annual Meeting, Palma Mallorca, Spain, 23.-25.1.2007

Philip J. B. Koeck, Pasi Purhonen, Ronny Alvang and Hans Hebert (2007): “Single-particle refinement of Melibiose Permease from images of two-dimensional crystals”, Network of Excellence-3DEM 3rd Annual Meeting, Palma Mallorca, Spain, 23.-25.1.2007

R. Alvang and P. J. B. Koeck (2007): ”Beyond Unbending – Crystal Variation as an Opportunity”, Network of Excellence-3DEM 3rd Annual Meeting, Palma Mallorca, Spain, 23.-25.1.2007

Philip J. B. Koeck, Pasi Purhonen, Ronny Alvang, Björn Grundberg and Hans Hebert (2007): “Single-particle refinement in electron crystallography of membrane-proteins”, Scandem 2007, Annual Meeting of the Nordic Microscopy Society, Espoo, Finland, 18. – 20.6.2007

Pasi Purhonen, Karen Thomsen, Philip J. B. Koeck, Arvid B. Maunsbach and Hans Hebert (2007): “Three-dimensional structure of renal Na,K-ATPase as determined by cryo-electron microscopy”, Scandem 2007, Annual Meeting of the Nordic Microscopy Society, Espoo, Finland, 18. – 20.6.2007

2006:

K. Cheng, P. J. B. Koeck, H. Elmlund, K. Idakieva, K. Parvanova, H. Schwarz, T. Ternström and H. Hebert (2006): ”Comparison of the two Rapana thomasiana Hemocyanin isoforms: RtH1 and RtH2”; 16. International Microscopy Conference, Sapporo, Japan, 3.–8.9.2006

R. Alvang, B. Grundberg, H. Hebert, P. J. B. Koeck (2006): ”Applications of Multivariate Methods in Electron Crystallography”, Network of Excellence-3DEM 2nd Annual Meeting, Klosters, Switzerland, 11.-14.1.2006

2004:

K. Cheng, P.J.B. Koeck, K. Idakieva, T. Ternström, K. Parvanova and H. Hebert (2004): ”Stainless Models of Rapana Thomasiana Hemocyanin”; Proc. of the 13th European Congress on Electron Microscopy, Antwerp, Belgium, August 22-27, 2004

P. Purhonen, B. Grundberg, R. Alvang, P.J.B. Koeck, K. Thomsen, H. Hebert and A.B. Maunsbach (2004): “Renal Na,K-ATPase Structure from Cryo-Electron Microscopy with 2-D Crystals Showing Structural Variability”; Proc. of the 13th European Congress on Electron Microscopy, Antwerp, Belgium, August 22-27, 2004

2003:

K. Cheng, M. Karlström, J. Sliauzyte, H. Hebert, R. Ladenstein and P.J.B. Koeck (2003): ”Structural Studies of an Archaeal Chaperonin by Electron Microscopy”; Structural Biology Network, Seventh Annual Conference, Tällberg, 2003

2001:

P.J.B. Koeck, W. Meining, M. Fischer, R. Ladenstein, A. Bacher, H. Hebert (2001): “Cryo Electron Microscopic Reconstruction of Icosahedral Capsids of the Lumazine Synthase - Dihydrofolate Reductase Fusion Protein”; Scandinavian Society for Electron Microscopy, 52nd Annual Conference, Stockholm, June 12-15, 2001

2000:

P. J. B. Koeck (2000): “Aliasing Correction of Undersampled Crystal Images”; Proc. of the 12th European Congress on Electron Microscopy, Brno, Czech Republic, July 9-14, 2000

J. Sliauzyte, P. J.B. Koeck, G. Tibbelin, R. Ladenstein, H. Hebert (2000): “Structural Characterisation of Reconstituted TF55- Oligomers”; Structural Biology Network, Forth Annual Conference, Tällberg, June 9-12, 2000

P. J.B. Koeck, J. Sliauzyte, G. Tibbelin, H. Hebert, R. Ladenstein (2000): “Structural Characterisation of Reconstituted TF55- Oligomers”; Proc. of the 12th European Congress on Electron Microscopy, Brno, Czech Republic, July 9-14, 2000

P.J.B. Koeck, W. Meining, M. Fischer, R. Ladenstein, A. Bacher, H. Hebert (2000): “Cryo Electron Microscopic Reconstruction of Icosahedral Capsids of the Lumazine Synthase - Dihydrofolate Reductase Fusion Protein”; Structural Biology Network, Forth Annual Conference, Tällberg, June 9-12, 2000

1998:

P. J. B. Koeck, H. K. Kagawa, H. Hebert, M. J. Ellis, J. D. Trent (1998): “Two-Dimensional Crystals of Reconstituted -Subunits of the Chaperonin TF55 from Sulfolobus shibatae”; Proc. of the 50th Annual Meeting of The Scandinavian Society for Electron Microscopy, Espoo and Helsinki, Finland, June 7-10, 1998

P. J. B. Koeck (1998): “Superresolution by Aliasing Correction of Undersampled Crystal Images”; Proc. of the 50th Annual Meeting of The Scandinavian Society for Electron Microscopy, Espoo and Helsinki, Finland, June 7-10, 1998

1997:

P. J. B. Koeck (1997): “Quantization Errors in Averaged Digitized Data”; Proc. of the 49th Annual Meeting of The Scandinavian Society for Electron Microscopy, Göteborg, Sweden, June 10-13, 1997

P. J. B. Koeck, S. Knapp, S. Fakoor-Biniaz, M. J. Ellis, R. Ladenstein, H. Hebert (1997): “Cryo electron microscopy of TF-55 single particles”; Structural Biology Network, First Annual Conference, Tällberg, June 6-9, 1997

1996:

P. J. B. Koeck, R. R. Schröder, K. R. Leonard, M. Haider (1996): "Unconventional Immuno Double Labelling by Energy Filtered Transmission Electron Microscopy"; Proc. of the 48th Annual Meeting of The Scandinavian Society for Electron Microscopy, Aarhus, Denmark, June 2-5, 1996

1995:

P. J. B. Koeck, R. R. Schröder, K. R. Leonard, M. Haider (1995): "Unconventional Immuno Double Labelling by Energy Filtered Transmission Electron Microscopy"; Fifth European Workshop on Electron Spectroscopic Imaging, Diffraction and Analysis Techniques, Freiburg, June 8-9, 1995

1994:

P. J. B. Koeck, M. Haider (1994): "Distinction of Gold and Silver Labels from the Plasmon Loss Peak of the Electron Energy Loss Spectrum for Immuno Double Labelling"; Abstracts of the 'Dreiländertagung Elektronenmikroskopie 1993'; Optik 94, supplement 5 and European Journal of Cell Biology 61, supplement 39; p. 107

Theses and Lecture Notes

2013:

P.J.B. Koeck (2013): “TEM-Image Formation in the Weak Amplitude and Phase Object Approximation”, lecture notes, Royal Institute of Technology

2010:

P. J. B. Koeck (2010): “Mathematical Methods for Three-Dimensional Imaging”, lecture notes, Royal Institute of Technology and Karolinska Institutet

2007:

P. J. B. Koeck (2007): “Introduction to Biophysical Transmission Electron Microscopy”, lecture notes, Royal Institute of Technology and Karolinska Institutet

2005:

P. J. Koeck (2005): “A General Description of Monoprotic Weak Acid-Base Equilibrium”, lecture notes, Södertörns Högskola and Karolinska Institutet

1999:

P.J.B. Koeck (1999): “Image Formation in the Electron Microscope”, lecture notes, Karolinska Institutet

1998:

P. J. B. Koeck (1998): “Transmission Electron Microscopy”, lecture notes in ‘Structural Biochemistry and Biophysics’ by K. D. Berndt, M. Flocco Henningson, H. Hebert, P. J. B. Koeck, L. Nilsson; Karolinska Institutet

P. J. B. Koeck, J. Hesse, H. Hebert (1998): “Scanners for High Resolution TEM”; invited talk, Proc. of the 50th Annual Meeting of The Scandinavian Society for Electron Microscopy, Espoo and Helsinki, Finland, June 7-10, 1998

1995:

P. J. B. Koeck (1995): “Unconventional Immuno Double Labelling by Electron Spectroscopic Imaging and Multivariate Statistical Analysis”, Doctoral Thesis at the ‘Karl-Franzens-Universität’ Graz, Austria

1991:

P. J. B. Koeck (1991): “Solvent and Deuteration Effects on the Primary Photoprocesses in Dihydrobiliverdin”, masters thesis at the ‘Karl-Franzens-Universität’ Graz, Austria

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