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Christofer Lendel

Profile picture of Christofer Lendel

ASSOCIATE PROFESSOR

Details

Address
TEKNIKRINGEN 30

Researcher


About me

Latest news

Protein nanofibrils from whey can be used to produce foams (aerogels). These foams have the facinating behavior of becoming stronger and stronger during incubation at temperatures that melt many other polymers. The foams also remain intact in harsh environments such as DTT+SDS+ 6M urea and in hot oil or diesel. Maybe proteins can be  the future material of choice for high temperature applicatins? The works was done in collaboration with Mikael Hedenqvist's group and is published in  Advances Sustainable Systems.

Press release from KTH.

Research Interests

The assembly of protein molecules into nanoscale aggregates and amyloid fibrils are key events in many biochemical processes ranging from neurodegenerative disorders, such as Alzheimer’s disease, to the design of novel nanomaterials. In my research I investigate the structural properties and interactions of such protein aggregates. In particular, I am interested in the molecular mechanisms for how protein nanostructures interact with other (bio)molecules.

 

New materials from protein nanofibrils

Protein nanofibrils display extraordinary mechanical and functional properties and has the potential to be used as building blocks for new materials with hieracrical structures. We develop methods to produce fibrils from protein-rich and renewable sources (e.g. plant proteins) and the technology to produce new protein-based materials.

 

Pathological mechanisms of protein aggregates

Protein self-assembly and deposition are hallmarks of many serious diseases but the disease-causing mechanisms remain enigmatic.  However, any pathological mechanism must involve interactions between the protein aggregates and other biomolecules. We explore and characterize such interactions in order to better understand what makes a protein nanostructure toxic.

 Interactions.png

 

Inhibitors of protein aggregation

The mechanisms of action for small molecule inhibitors of protein aggregation remain poorly understood and the development of new therapeutics against amyloid diseases is slow. Interfering with protein self-assembly is complicated and essentially different from traditional drug design. By studying the binding mechanisms of small molecules to aggregation-prone proteins we believe that we will better understand what type of molecules could be explored as drug candidates for amyloid-diseases.

Small_molecule.png

Group members

Vasantha Gowda (Post doc)
Mahafuzur Rahman (Post Doc)
Danilo Kimio Hirabae de Oliviera (PhD student, joint with My Hedhammar)
Rodrigo Sanches Pires (PhD student)

Selected publications

Extracellular protein components of amyloid plaques and their roles in Alzheimer’s disease pathology (review). Rahman, M. M. & Lendel, C. (2021) Mol. Neurodegen. (2021).

Dissecting the structural organization of multiprotein amyloid aggregates using a bottom-up approach. Chaudhary et al. ACS Chem. Neurosci. (2020).

Flow-assisted assembly of nanostructured protein microfibers. Kamada et al. Proc. Natl. Acad. Sci. USA (2017).

Binding of human proteins to amyloid-β protofibrils. Rahman et al. ACS Chem. Biol. (2015). 

A hexameric peptide barrel as building block of amyloid-β protofibrils. Lendel et al. Angew. Chem. Int. Ed (2014).

Inhibition of amyloid formation (review). Härd & Lendel J. Mol. Biol. (2012).

Hydrophobicity and conformational change as mechanistic determinants of non-specific modulators of amyloid β self-assembly. Abelein et al. Biochemistry (2012).

On the mechanism of non-specific inhibitors of protein aggregation: Dissecting the interactions of a-synuclein with Congo red and Lacmoid. Lendel et al. Biochemistry (2009).

 


Courses

Analysis of Biomolecules (BB1200), teacher | Course web

Degree Project in Chemistry, Second Cycle (KD200X), examiner | Course web

Degree Project in Engineering Chemistry, First Cycle (KA103X), teacher, assistant | Course web

Engineering Chemistry (KE1140), assistant | Course web

Introductory Chemistry (KD1020), teacher | Course web

Molecular Structure (KD1070), teacher | Course web

Project in Chemistry (KD2910), examiner | Course web

Project in Chemistry (KD2905), examiner | Course web

Research Frontiers in Chemistry (FCK3315), examiner, course responsible, teacher | Course web

Thermodynamics (KE1160), course responsible | Course web